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    Biotechnology Detecting Device with Optical Fibers and LEDs
    1.
    发明申请
    Biotechnology Detecting Device with Optical Fibers and LEDs 审中-公开
    具有光纤和LED的生物检测装置

    公开(公告)号：US20130149197A1

    公开(公告)日：2013-06-13

    申请号：US13494734

    申请日：2012-06-12

    Applicant: Shien-Kuei Liaw ,  Chia-Ching Chang ,  Shin-Hua Tseng ,  Yi-Lin Yu ,  Shu-Chuan Lin ,  Hung-Wei Chen

    Inventor： Shien-Kuei Liaw ,  Chia-Ching Chang ,  Shin-Hua Tseng ,  Yi-Lin Yu ,  Shu-Chuan Lin ,  Hung-Wei Chen

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  G01N2021/6482 ,  G01N2021/6484

    Abstract: A biotechnology detection device with optical fibers comprises a first optical fiber connected to a light source, and a prism having a first surface and a second surface. The first surface is connected to the first optical fiber and coated with an anti-reflective layer to be passed through by short-wavelength light; a second optical fiber connected to the second surface of the prism. The end of the second optical fiber is to be coated with test sample blended with a fluorescent agent, wherein the fluorescent agent emits long-wavelength light after being excited by short-wavelength light. The second prism surface is coated with a high reflective layer to reflect part of the long-wavelength light. A third optical fiber is connected to the second prism surface to convey part of the long-wavelength light. A detector is connected to the third optical fiber for detecting part of the long-wavelength light.

    Abstract translation: 具有光纤的生物技术检测装置包括连接到光源的第一光纤和具有第一表面和第二表面的棱镜。 第一表面连接到第一光纤并涂覆有通​​过短波长光通过的抗反射层; 连接到棱镜的第二表面的第二光纤。 第二光纤的端部涂覆有与荧光剂混合的测试样品，其中荧光剂在被短波长光激发后发射长波长的光。 第二棱镜表面涂覆有高反射层以反射部分长波长光。 第三光纤连接到第二棱镜表面以传送部分长波长光。 检测器连接到第三光纤，用于检测部分长波长光。

    POLYSACCHARIDE-PROTEIN BINDING MODEL AND NANO-FIBRIL FORMATION OF A STARCH BINDING DOMAIN
    2.
    发明申请
    POLYSACCHARIDE-PROTEIN BINDING MODEL AND NANO-FIBRIL FORMATION OF A STARCH BINDING DOMAIN 有权
    多糖 - 蛋白质结合模型和纳米纤维形成淀粉结合域

    公开(公告)号：US20110129853A1

    公开(公告)日：2011-06-02

    申请号：US13009650

    申请日：2011-01-19

    Applicant: Margaret Dah-Tsyr Chang ,  Yuh-Ju Sun ,  Ping-Chiang Lyu ,  Shu-Chuan Lin ,  Wei-I Chou

    Inventor： Margaret Dah-Tsyr Chang ,  Yuh-Ju Sun ,  Ping-Chiang Lyu ,  Shu-Chuan Lin ,  Wei-I Chou

    IPC: G01N33/53

    CPC classification number: C12N9/2428 ,  C07K7/08 ,  C07K2319/00 ,  C12Y302/01003

    Abstract: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.

    Abstract translation: SBD的多糖 - 蛋白质结合模型和由X1NNNX2X3NYQX4X5X6X7X8组成的原纤维形成的14残基肽，其中X1和X8表示一对相对带电的氨基酸残基，X2，X3，X4，X5，X6或 X7表示氨基酸残基。 还提供了用于减少多糖的混合物，其包含至少两种淀粉结合结构域（SBD）和螺旋形式的多糖。 进一步描述提供寡糖的方法和淀粉样样原纤维的生产方法及其用途。

    HEPARIN BINDING MOTIF AND USE THEREOF
    3.
    发明申请
    HEPARIN BINDING MOTIF AND USE THEREOF 审中-公开
    HEPARIN BINDING MOTIF及其使用

    公开(公告)号：US20100016239A1

    公开(公告)日：2010-01-21

    申请号：US12545606

    申请日：2009-08-21

    Applicant: Margaret Dah-Tsyr Chang ,  Tan-chi Fan ,  Shu-Chuan Lin

    Inventor： Margaret Dah-Tsyr Chang ,  Tan-chi Fan ,  Shu-Chuan Lin

    IPC: A61K38/08 ,  C07K7/06 ,  A61K38/10 ,  A61P11/06

    CPC classification number: C07K14/47 ,  C12N9/22

    Abstract: A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.

    Abstract translation: 一种用于降低嗜酸性粒细胞衍生毒素的细胞毒性的方法，包括对受试者施用有效量的肝素，硫酸乙酰肝素，有效的乙酰肝素酶抑制剂或具有如下序列的多肽：BZBXBX，XBBBXXBX，XBBXBX，BBXXBBBBBBB，BXBBXB，XBBBXXBBBBBBX或TXXBXXTBXXXXBBB 其中X表示任何氨基酸，Z表示芳香族氨基酸，B表示碱性氨基酸，T表示匝数。

    Heparin binding motif and use thereof
    4.
    发明授权
    Heparin binding motif and use thereof 有权
    肝素结合基序及其用途

    公开(公告)号：US07595374B1

    公开(公告)日：2009-09-29

    申请号：US12125008

    申请日：2008-05-21

    Applicant: Margaret Dah-Tsyr Chang ,  Tan-chi Fan ,  Shu-Chuan Lin

    Inventor： Margaret Dah-Tsyr Chang ,  Tan-chi Fan ,  Shu-Chuan Lin

    IPC: C07K14/435 ,  C07K14/475

    CPC classification number: C07K14/47 ,  C12N9/22

    Abstract: A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.

    Abstract translation: 一种用于降低嗜酸性粒细胞衍生毒素的细胞毒性的方法，包括对受试者施用有效量的肝素，硫酸乙酰肝素，有效的乙酰肝素酶抑制剂或具有如下序列的多肽：BZBXBX，XBBBXXBX，XBBXBX，BBXXBBBBBBB，BXBBXB，XBBBXXBBBBBBX或TXXBXXTBXXXXBBB 其中X表示任何氨基酸，Z表示芳香族氨基酸，B表示碱性氨基酸，T表示匝数。

    Process for making mycophenolate mofetil by transesterification
    5.
    发明授权
    Process for making mycophenolate mofetil by transesterification 有权
    通过酯交换制备霉酚酸酯的方法

    公开(公告)号：US07019133B2

    公开(公告)日：2006-03-28

    申请号：US10750466

    申请日：2003-12-29

    Applicant: Kwang-Chung Lee ,  Shu-Chuan Lin ,  Ray-Hwa Chiu

    Inventor： Kwang-Chung Lee ,  Shu-Chuan Lin ,  Ray-Hwa Chiu

    IPC: C07D413/02

    CPC classification number: C07D307/88

    Abstract: A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.

    Abstract translation: 一种制备霉酚酸酯的方法，其包括：通过使霉酚酸的低碳烷基酯与2-吗啉代乙醇[也称为4-（2-羟乙基）吗啉]反应进行催化酯交换，得到霉酚酸酯的粗产物，其中mycophenolate mofetil 然后分离和纯化。

    Cell penetrating peptides for intracellular delivery
    6.
    发明授权
    Cell penetrating peptides for intracellular delivery 有权
    细胞穿透肽用于细胞内递送

    公开(公告)号：US08372951B2

    公开(公告)日：2013-02-12

    申请号：US12780497

    申请日：2010-05-14

    Applicant: Margaret Dah-Tsyr Chang ,  Shun-Lung Fang ,  Wei-I Chou ,  Shu-Chuan Lin

    Inventor： Margaret Dah-Tsyr Chang ,  Shun-Lung Fang ,  Wei-I Chou ,  Shu-Chuan Lin

    IPC: C07K7/00 ,  C07K7/06 ,  A61K38/00 ,  A61K38/08

    CPC classification number: C07K14/52 ,  A61K38/00 ,  C07K14/47

    Abstract: A cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none is described. A method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject is also described.

    Abstract translation: 具有以下序列的细胞穿透肽：NYBX1BX2BNQX3，其中B表示碱性氨基酸，X1表示具有芳香族，疏水性或不带电侧链的氨基酸，X2表示任何氨基酸，X3表示N或不描述 。 还描述了通过将包含细胞穿透肽和期望的货物的复合物给予受试者来将货物递送到受试者的方法。

    POLYSACCHARIDE-PROTEIN BINDING MODEL AND NANO-FIBRIL FORMATION OF A STARCH BINDING DOMAIN
    9.
    发明申请
    POLYSACCHARIDE-PROTEIN BINDING MODEL AND NANO-FIBRIL FORMATION OF A STARCH BINDING DOMAIN 有权
    多糖 - 蛋白质结合模型和纳米纤维形成淀粉结合域

    公开(公告)号：US20090186369A1

    公开(公告)日：2009-07-23

    申请号：US12359035

    申请日：2009-01-23

    Applicant: Margaret Dah-Tsyr Chang ,  Yuh-Ju Sun ,  Ping-Chiang Lyu ,  Shu-Chuan Lin ,  Wei-I Chou

    Inventor： Margaret Dah-Tsyr Chang ,  Yuh-Ju Sun ,  Ping-Chiang Lyu ,  Shu-Chuan Lin ,  Wei-I Chou

    IPC: C12Q1/40 ,  C12N9/34 ,  C07K14/00 ,  C07K1/00

    CPC classification number: C12N9/2428 ,  C07K7/08 ,  C07K2319/00 ,  C12Y302/01003

    Abstract: The present invention relates to a polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue. The present invention also relates to a mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form. The present invention further relates to a method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof.

    Abstract translation: 本发明涉及SBD的多糖 - 蛋白结合模型和由X1NNNX2X3NYQX4X5X6X7X8组成的原纤维形成的14残基肽，其中X1和X8表示一对相对带电的氨基酸残基，X2，X3，X4， X5，X6或X7表示氨基酸残基。 本发明还涉及用于减少多糖的混合物，其包含至少两种淀粉结合结构域（SBD）和螺旋形式的多糖。 本发明还涉及提供寡糖的方法，以及淀粉样样原纤维的制造方法及其用途。

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