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11.发明申请公开(公告)号：US20140309254A1
公开(公告)日：2014-10-16
申请号：US14316503
申请日：2014-06-26
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： C07D471/04 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书中所述， 制备它们的过程，以及它们作为药物的用途。
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公开(公告)号：US08288588B2
公开(公告)日：2012-10-16
申请号：US13165048
申请日：2011-06-21
IPC分类号： C07C311/00
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 本发明涉及其中X，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物，其可用于治疗对CXCR2受体介体作出反应的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20110009429A1
公开(公告)日：2011-01-13
申请号：US12867569
申请日：2009-02-25
IPC分类号： A61K31/519 , C07D487/04 , A61P37/08 , A61P29/00 , A61P11/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, X, Y and Z are as defined in the specification.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X，Y和Z如说明书中所定义。
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公开(公告)号：US20100210610A1
公开(公告)日：2010-08-19
申请号：US12699723
申请日：2010-02-03
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： A61K31/56 , C07D471/04 , A61K31/437 , C07D413/12 , A61K31/5377 , A61P11/00 , A61P11/08 , A61P11/14 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：US09862711B2
公开(公告)日：2018-01-09
申请号：US15303890
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Ian Bruce , Andrew James Culshaw , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Ian Bruce , Andrew James Culshaw , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D409/04 , C07D405/14 , C07D403/14 , A61K31/5377 , A61K31/497
CPC分类号： C07D417/04 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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公开(公告)号：US20170029414A1
公开(公告)日：2017-02-02
申请号：US15303890
申请日：2014-04-24
申请人： Benjamin Richard BELLENIE , Ian BRUCE , Andrew James CULSHAW , Gregory John HOLLINGWORTH , James NEEF , Matthew SPENDIFF , Simon James WATSON
发明人： Benjamin Richard BELLENIE , Ian BRUCE , Andrew James CULSHAW , Gregory John HOLLINGWORTH , James NEEF , Matthew SPENDIFF , Simon James WATSON
IPC分类号： C07D417/04 , C07D403/04 , C07D409/04 , A61K31/5377 , C07D401/04 , A61K31/497 , C07D405/14
CPC分类号： C07D417/04 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要翻译： 本发明提供抑制PI 3激酶γ同种型活性的式（I）化合物，其可用于治疗由PI3激酶γ同种型激活介导的疾病。
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公开(公告)号：US08455645B2
公开(公告)日：2013-06-04
申请号：US12699723
申请日：2010-02-03
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。
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公开(公告)号：US20100029670A1
公开(公告)日：2010-02-04
申请号：US12512609
申请日：2009-07-30
IPC分类号： A61K31/497 , C07D307/02 , C07D333/22 , C07D241/02 , C07D211/70 , A61K31/44 , A61K31/381 , A61K31/341 , A61P35/00
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 本发明涉及其中X，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物，其可用于治疗对CXCR2受体介体作出反应的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20090048281A1
公开(公告)日：2009-02-19
申请号：US11577417
申请日：2005-10-31
申请人： Neil John Press , Stephen Paul Collingwood , Urs Baettig , Brian Cox , Sudhakar Devidasrao Garad , Hyungchul Kim , Dimitris Papoutsakis , Simon James Watson
发明人： Neil John Press , Stephen Paul Collingwood , Urs Baettig , Brian Cox , Sudhakar Devidasrao Garad , Hyungchul Kim , Dimitris Papoutsakis , Simon James Watson
IPC分类号： C07D453/02 , A61K31/439 , A61K31/506 , A61P29/00 , A61P11/00
CPC分类号： C07D453/02
摘要： Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 式（I）化合物; 盐或两性离子形式，其中R 1，R 2，R 3和R 4具有说明书中指出的含义，可用于治疗由毒蕈碱M3受体介导的病症，特别是炎性或阻塞性气道疾病。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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公开(公告)号：US06921757B2
公开(公告)日：2005-07-26
申请号：US10312021
申请日：2001-06-26
申请人： Bernard Cuenoud , David Beattie , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , David Andrew Sandham , Simon James Watson
发明人： Bernard Cuenoud , David Beattie , Thomas Hugo Keller , Gaynor Elizabeth Pilgrim , David Andrew Sandham , Simon James Watson
IPC分类号： A61K31/56 , A61P11/08 , A61P29/00 , A61P43/00 , C07C401/00 , C07J3/00 , C07J17/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J71/00 , A61K31/58
CPC分类号： C07J41/0038 , C07J3/005 , C07J17/00 , C07J33/002 , C07J41/0094 , C07J43/003 , C07J71/0015
摘要： Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals
摘要翻译： 式（I）化合物，其中R是环系中具有3至15个原子的一价环状有机基团，可用作药物
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