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    Applications of single molecule sequencing
    12.
    发明申请
    Applications of single molecule sequencing 审中-公开
    单分子测序的应用

    公开(公告)号：US20060046258A1

    公开(公告)日：2006-03-02

    申请号：US11067102

    申请日：2005-02-25

    Applicant: Stanley Lapidus ,  Stephen Quake

    Inventor： Stanley Lapidus ,  Stephen Quake

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q1/6869 ,  C12Q2600/156

    Abstract: The invention provides methods for determining the presence of a disease by comparing a sequence from a single target molecule with a predetermined sequence that is associated with a specific disease.

    Abstract translation: 本发明提供了通过将来自单个靶分子的序列与与特定疾病相关的预定序列进行比较来确定疾病存在的方法。

    Methods for nucleic acid amplification and sequence determination
    13.
    发明申请
    Methods for nucleic acid amplification and sequence determination 审中-公开
    核酸扩增和序列测定方法

    公开(公告)号：US20060024711A1

    公开(公告)日：2006-02-02

    申请号：US11167046

    申请日：2005-06-23

    Applicant: Stanley Lapidus ,  Philip Buzby

    Inventor： Stanley Lapidus ,  Philip Buzby

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6806 ,  C12Q1/6869 ,  C12Q2565/501 ,  C12Q2531/125

    Abstract: The invention provides methods for sequencing a nucleic acid comprising conducting rolling circle amplification on a circular nucleic acid template, wherein the resulting amplicon is optionally anchored to a substrate in an individually optically resolvable manner, and performing a sequencing reaction.

    Abstract translation: 本发明提供了用于对核酸进行测序的方法，包括在环状核酸模板上进行滚环扩增，其中所得扩增子任选地以单独光学可分辨的方式锚定于底物，并进行测序反应。

    Methods and devices for sequencing nucleic acids
    14.
    发明申请
    Methods and devices for sequencing nucleic acids 审中-公开
    测序核酸的方法和装置

    公开(公告)号：US20050260609A1

    公开(公告)日：2005-11-24

    申请号：US10852028

    申请日：2004-05-24

    Applicant: Stanley Lapidus

    Inventor： Stanley Lapidus

    IPC: C12Q1/68 ,  C07H21/04

    CPC classification number: C12Q1/6869

    Abstract: The invention provides methods and devices for high throughput single molecule sequencing of a plurality of target nucleic acids using a universal primer. Devices of the invention comprise a plurality of oligonucleotides, each having the same sequence, bound to a solid support, and ligated to a plurality of target nucleic acids.

    Abstract translation: 本发明提供使用通用引物对多个靶核酸进行高通量单分子测序的方法和装置。 本发明的装置包含多个寡核苷酸，每个具有相同的序列，与固体支持物结合，并连接到多个靶核酸。

    METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES
    18.
    发明申请
    METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES 审中-公开
    用于检测天然核酸的方法和诊断宫颈异常

    公开(公告)号：US20100216151A1

    公开(公告)日：2010-08-26

    申请号：US12709057

    申请日：2010-02-19

    Applicant: STANLEY LAPIDUS ,  JOHN F. THOMPSON ,  DORON LIPSON ,  PATRICE MILOS ,  J. WILLIAM EFCAVITCH ,  STANLEY LETOVSKY

    Inventor： STANLEY LAPIDUS ,  JOHN F. THOMPSON ,  DORON LIPSON ,  PATRICE MILOS ,  J. WILLIAM EFCAVITCH ,  STANLEY LETOVSKY

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/156

    Abstract: The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.

    Abstract translation: 本发明一般涉及用于检测胎儿核酸的方法和用于诊断胎儿异常的方法。 在某些实施方案中，本发明提供了用于确定胎儿核酸是否存在于母体样品中的方法，包括获得怀疑包括胎儿核酸的母体样品，并对样品进行测序反应以确定至少部分 Y染色体，从而确定胎儿核酸存在于样品中。 在其它实施方案中，本发明提供用于定量或定性分析以检测母体样品中的胎儿核酸的方法，而不管检测Y染色体的能力，特别是对于包括来自雌性胎儿的正常核酸的样品的检测能力。

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