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公开(公告)号：US08039661B2
公开(公告)日：2011-10-18
申请号：US12942287
申请日：2010-11-09
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: C07C209/22
CPC classification number: C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US07851495B2
公开(公告)日：2010-12-14
申请号：US11805243
申请日：2007-05-22
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/4196 , C07D249/08
CPC classification number: C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US07829590B2
公开(公告)日：2010-11-09
申请号：US11786579
申请日：2007-04-12
Applicant: Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/4155 , A61K31/4178 , C07D231/38 , C07D233/54
CPC classification number: C07D409/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase, represented by structural formula I: or pharmaceutically acceptable salts thereof, wherein values of the variables of structural formula are as described in the specification and claims. The invention also provides pharmaceutically acceptable compositions comprising the compounds or salts, and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及用作结构式I表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中结构式变量的值如说明书和权利要求书所述。 本发明还提供包含该化合物或盐的药学上可接受的组合物，以及使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供制备本发明化合物的方法。
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公开(公告)号：US07786130B2
公开(公告)日：2010-08-31
申请号：US11511086
申请日：2006-08-28
Applicant: Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
Inventor： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC: C07D401/04 , A61K31/44
CPC classification number: C07D213/64 , C07D401/14 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20090281082A1
公开(公告)日：2009-11-12
申请号：US12466420
申请日：2009-05-15
Applicant: Ronald Knegtel , Jean-Damien Charrier , Steven Durrant , Guy Brenchley , Michael Mortimore
Inventor： Ronald Knegtel , Jean-Damien Charrier , Steven Durrant , Guy Brenchley , Michael Mortimore
IPC: A61K31/55 , C07D495/02 , C07D513/04 , A61K31/5513 , A61P35/02 , A61P35/00 , C12N9/99
CPC classification number: C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20080070965A1
公开(公告)日：2008-03-20
申请号：US11805243
申请日：2007-05-22
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/41 , C07D249/08
CPC classification number: C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US20080045570A1
公开(公告)日：2008-02-21
申请号：US11805418
申请日：2007-05-23
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/44 , A61P35/00 , C07D409/04 , C12N9/99
CPC classification number: C07D409/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20070179177A1
公开(公告)日：2007-08-02
申请号：US11600311
申请日：2006-11-15
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadig , Jingrong Cao
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadig , Jingrong Cao
IPC: A61K31/4745 , A61K31/498 , C07D487/02 , C07D471/02
CPC classification number: C07D471/02 , C07D471/04 , C07D487/02
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08338597B2
公开(公告)日：2012-12-25
申请号：US13325089
申请日：2011-12-14
Applicant: Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
Inventor： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC: C07D239/02 , A61K31/515
CPC classification number: C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
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20.发明申请METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS 有权用于制备作为蛋白激酶抑制剂有用的吡啶衍生物的方法公开(公告)号：US20120271045A1
公开(公告)日：2012-10-25
申请号：US13497139
申请日：2012-03-20
Applicant: Jean-Damien Charrier , Steven Durrant , Michael O'Donnell
Inventor： Jean-Damien Charrier , Steven Durrant , Michael O'Donnell
IPC: C07D487/04 , C07D475/00
CPC classification number: C07D475/00 , C07D475/10 , C07D487/04
Abstract: A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims. Additionally, the present invention relates to compounds of Structural Formula (I), which are useful as inhibitors of protein kinase.
Abstract translation: 制备由结构式（I）表示的化合物或其药学上可接受的盐的方法，其中结构式（I）的变量如说明书和权利要求书中所述。 另外，本发明涉及结构式（I）的化合物，其可用作蛋白激酶的抑制剂。
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