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公开(公告)号：US20250152696A1
公开(公告)日：2025-05-15
申请号：US18683238
申请日：2022-08-13
Applicant: Purdue Research Foundation , The United States of America as represented by the Secretary, Department of Health and Human Service , The Methodist Hospital
Inventor： Suresh MITTAL , Suryaprakash SAMBHARA , Ekramy SAYEDAHMED , Chinnaswamy JAGANNATH
IPC: A61K39/145 , A61K39/00 , A61P37/04
Abstract: An adenoviral vector with E1 and E3 regions removed and expressing the nucleoprotein or other immunogenic domain(s) of an influenza virus with or without the presence of the Autophagy-Inducing Peptide C5 (AIP-C5) from the CFP10 protein of Mycobacterium tuberculosis, compositions comprising same, and methods of use for general vaccination against heterosubtypic influenza viruses.
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公开(公告)号：US12297126B1
公开(公告)日：2025-05-13
申请号：US17709551
申请日：2022-03-31
Inventor： Gary Anguiano , Dennis How , Mark Foreman , James Thomas Pilkington
Abstract: A modular porous swale. The modular porous swale may comprise a porous concrete block and filtration joint. The porous concrete block may snugly fit within a trench having a lower portion filled with an absorption media. The absorption media may include gravel, activated alumina, bone char, biochar, bone char and activated alumina mixture, and biochar and activated alumina mixture. The porous concrete block may have a top surface inwardly-sloped to a nadir. The filtration joint may be disposed within the porous concrete block and along the nadir. The liner may cover one or more sides of the porous concrete block. The perforated pipe may be located within the absorption media. The filtration joint may substantially align above a portion of the perforated pipe when the modular porous swale is installed within the trench.
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公开(公告)号：US20250148176A1
公开(公告)日：2025-05-08
申请号：US18912204
申请日：2024-10-10
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Mark Fry
IPC: G06F30/28 , A01G15/00 , G06F113/08
Abstract: In an example, a system to modify a severe weather vortex comprises a controller configured to specify initial conditions for formation of the severe weather vortex, model the severe weather vortex with equations of fluid dynamics based on the initial conditions to produce a simulated severe weather vortex, and computationally add energy to a vortex generation area at an upper part of the simulated severe weather vortex to modify the simulated severe weather vortex to disrupt at least one of the formation or a travel path of the simulated severe weather vortex. A steerable mirror is oriented to focus solar energy from the sun at a vortex generation area at an upper part of the severe weather vortex based on the energy computationally added to modify the simulated severe weather vortex.
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公开(公告)号：US20250146716A1
公开(公告)日：2025-05-08
申请号：US18939235
申请日：2024-11-06
Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
Inventor： Matthew Wiese , Bradley Segelhorst , John Montgomery
Abstract: Systems and methods are provided for additively manufactured vascular networks that can allow for large areas of a plate or structure to be maintained at a constant and even temperature throughout a wide range of applied heat loads, even if the heat load is applied only on portions of the surface. An additively manufactured vascular network in accordance with an embodiment of the present disclosure is a cost effective way of adding this thermal management solution over other more labor intensive options or methods with higher initial costs. Applications for additively manufactured vascular networks in accordance with an embodiment of the present disclosure can be found in a wide range of land, sea, air, and space environments.
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公开(公告)号：US20250138138A1
公开(公告)日：2025-05-01
申请号：US18518160
申请日：2023-11-22
Inventor： Mark William Owen , Barry R. Hunt , Bieu Van Lu
Abstract: Radar intercept hardware is capable of receiving and storing multiple radar signals in any context including air, land, sea or space domains as radar pulse data. However, without a priori knowledge of all of the radar emitters captured by such radar interceptors, the information or intelligence that has been gathered is of little use until such radar signals are separated or deinterleaved from the radar pulse data. The present invention is directed to model-based radar signal deinterleaver systems and methods. The characteristics of known radar models, particularly pulse repetition intervals, pulse width, time of arrival and radio frequency are used by the various embodiments of the system and method of the present invention to extract out the known signals and leave the unknown or residue signals for adjudication by a subject matter expert.
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Patent Agency Ranking
公开(公告)号：US20250134897A1
公开(公告)日：2025-05-01
申请号：US18833627
申请日：2023-01-26
Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
Inventor： Rolf E. SWENSON , Jessica H. ETTEDGUI-BENJAMINI , Venkatareddy SABBASANI , Deepak SAIL , Kazutoshi YAMAMOTO , Murali K. CHERUKURI
IPC: A61K31/5375 , A61K31/194 , C07C51/41 , C07C59/347 , C07D295/185
Abstract: Disclosed are compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods of preparation thereof, wherein R1, Xa, Xb, Xc, and Xd are as described in the specification. Further disclosed is an isotopic mixture of a compound of Formula (I), as well as a pharmaceutical composition containing a hyperpolarized compound of Formula (I). Also disclosed is a method of diagnosing or monitoring a patient suffering from cancer, the method including administering a pharmaceutical composition comprising an effective amount of a hyperpolarized ketoglutarate compound or a pharmaceutically acceptable salt thereof, and measuring the hyperpolarization of a compound of interest in the patient. Further disclosed is a method of preparing hyperpolarized ketoglutarate compounds for use in the above methods.
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公开(公告)号：US12288136B2
公开(公告)日：2025-04-29
申请号：US18654208
申请日：2024-05-03
Applicant: University of Maryland, College Park , Government of the United States of America, as Represented by the Secretary of Commerce
Inventor： Seyed Alireza Seif Tabrizi , Mohammad Hafezi , Yi-Kai Liu
IPC: G06N10/70
Abstract: A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix.
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公开(公告)号：US12287340B2
公开(公告)日：2025-04-29
申请号：US18414339
申请日：2024-01-16
Applicant: Wayne State University , The United States of America, as Represented by the Secretary, Department of Health & Human Services
Inventor： Adi L. Tarca , Piya Chaemsaithong , Tinnakorn Chaiworapongsa , Sonia S. Hassan , Roberto Romero
Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.
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公开(公告)号：US12286533B2
公开(公告)日：2025-04-29
申请号：US17734921
申请日：2022-05-02
Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
Inventor： Albert Epshteyn , Matthew Laskoski , Brian Chaloux , Tristan Butler
Abstract: Carbon phosphonitride (CPN) including tricyanophosphine (P(CN)3), its pre-polymer (CPN-PP), and/or solid CPN(C3N3P) can serve as a useful additive for thermoset resins, resulting in improved thermal and mechanical properties.
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20.发明申请公开(公告)号：US20250129382A1
公开(公告)日：2025-04-24
申请号：US18982427
申请日：2024-12-16
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Stephen G. Kaler
Abstract: Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy.
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