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    Methods and apparatus for determining the rate of movement of a study substance through a membrane
    14.
    发明授权
    Methods and apparatus for determining the rate of movement of a study substance through a membrane 失效
    用于确定研究物质通过膜的移动速率的方法和装置

    公开(公告)号：US4740309A

    公开(公告)日：1988-04-26

    申请号：US901659

    申请日：1986-08-29

    Applicant: Takeru Higuchi

    Inventor： Takeru Higuchi

    IPC: B01D61/28 ,  G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  B01D13/00

    CPC classification number: B01D61/28 ,  G01N13/00 ,  G01N2013/006 ,  G01N2035/00198 ,  G01N33/15

    Abstract: A diffusion cell for use in determining the absorption rate of a study substance through a permeable membrane. The cell includes a receptor chamber which contains receptor fluid to receive study substance absorbed through the membrane. The receptor chamber includes a fluid inlet and a fluid outlet. A rotary stirrer is situated adjacent the fluid outlet. The stirrer is rotated so as to rotate the receptor fluid in the receptor chamber in such manner that the fluid pressure is greater at the outlet than at the inlet, so that the stirrer defines a pump which pumps receptor fluid outwardly through the outlet, then through a detector, and then back into the receptor chamber through the inlet. The detector determines the concentration of study substance within the receptor fluid.

    Abstract translation: 用于通过可渗透膜测定研究物质的吸收速率的扩散池。 细胞包括受体腔室，其包含受体液体以接收通过膜吸收的研究物质。 受体室包括流体入口和流体出口。 旋转搅拌器位于流体出口附近。 旋转搅拌器以使接收器腔中的受体流体以这样的方式旋转，使得出口处的流体压力大于在入口处的流体压力，使得搅拌器限定泵，其将受体流体向外通过出口泵送，然后通过 检测器，然后通过入口回到受体室。 检测器确定研究物质在受体液体内的浓度。

    Method of increasing oral absorption of glycosidic and related antibiotics
    17.
    发明授权
    Method of increasing oral absorption of glycosidic and related antibiotics 失效
    增加糖苷及相关抗生素口服吸收的方法

    公开(公告)号：US4459295A

    公开(公告)日：1984-07-10

    申请号：US387409

    申请日：1982-06-11

    Applicant: Takeru Higuchi ,  Toshiaki Nishihata

    Inventor： Takeru Higuchi ,  Toshiaki Nishihata

    IPC: A61K9/20 ,  A61K9/28 ,  A61K9/48 ,  A61K45/06 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K31/71

    CPC classification number: A61K31/70 ,  A61K45/06 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K9/2013 ,  A61K9/4858 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/4891

    Abstract: A method and drug form are provided for increasing the oral absorption of glycosidic and related antibiotics such as macrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt thereof. The hydroxyaryl or hydroxyaralkyl acid or salt thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.

    Abstract translation: 提供了一种方法和药物形式，用于通过在合适的药学上可接受的赋形剂中口服所述糖苷和相关抗生素来增加糖苷类和相关抗生素如大环内酯类，氨基糖苷类，林可霉素和蒽环类抗生素及相关化学物质的口服吸收， 加入羟基芳基或羟基烷基酸或其盐。 羟基芳基或羟基烷基酸或其盐以足以有效提高糖苷和相关抗生素的口服吸收速率的药物形式存在。

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