公开(公告)号：US6163149A

公开(公告)日：2000-12-19

申请号：US51575

申请日：1998-04-06

申请人： Hans-Peter Loffler

发明人： Hans-Peter Loffler

IPC分类号： G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  G01N27/74

CPC分类号： G01N33/15 ,  G01N13/00 ,  G01N2013/006 ,  G01N2035/00198

摘要： The invention relates to a device for determining the dissolution time of medication in pressed form, like tablets and capsules, (especially to DAB 10, 3rd Supplement 1994, or the European Pharmacopoeia or USP [USA]), consisting of a frame (1) with a central column (7) and a base plate (3, 10) having a plurality of holes (5, 5', 11) covered from below by a mesh (4). Test tubes (6, 6') are arranged upright in said holes inside the frame (1). A disk (8, 15) can be movably inserted into said test tubes to weight the individual pressed medication. An electric coil (12) is disposed around each hole (11) and on and/or in the base plate (10), wherein the electric coil forms part of an electrical oscillation circuit (17). A conductor loop (16) is disposed on and/or in the disk (15) for damping the electrical oscillation circuit (17) depending on distance. The electric coil (12) and the conductor loop (16) together are connected to an electric supply and evaluation device (20, 23) to generate oscillations and evaluate the measurement results.

摘要翻译： PCT No.PCT / DE96 / 01771 Sec。 371日期：1998年4月6日 102（e）1998年4月6日PCT PCT 1996年9月19日PCT公布。 公开号WO97 / 14035 日期1997年04月17日本发明涉及一种用于确定压片形式药物溶出时间的装置，如片剂和胶囊（特别是DAB 10，3rd Supplement 1994，或欧洲药典或USP [USA]），由 具有中心柱（7）的框架（1）和具有由下面由网（4）覆盖的多个孔（5,5'，11）的基板（3,10）。 试管（6,6'）直立放置在框架（1）内的所述孔内。 盘（8,15）可以可移动地插入到所述试管中以对各个按压的药物进行加重。 电气线圈（12）围绕每个孔（11）设置在基板（10）上和/或底板（10）中，其中电线圈形成电振荡电路（17）的一部分。 导体环（16）设置在盘（15）上和/或中，用于根据距离阻尼电振荡电路（17）。 电线圈（12）和导体回路（16）一起连接到电源和评估装置（20,23）以产生振荡并评估测量结果。

公开(公告)号：US5490415A

公开(公告)日：1996-02-13

申请号：US227964

申请日：1994-04-15

申请人： Vivien H. W. Mak ,  Michael L. Francoeur

发明人： Vivien H. W. Mak ,  Michael L. Francoeur

IPC分类号： G01N13/00 ,  G01N13/04 ,  G01N33/15 ,  G01N35/00

CPC分类号： G01N13/00 ,  G01N13/04 ,  G01N2035/00198 ,  G01N33/15

摘要： A diffusion test apparatus (2), used to test diffusion of a drug within a vehicle through a test membrane (8), includes a receiver assembly (6) and a donor assembly (4) secured to one another. The receiver assembly includes a number of open-top receiver receptacles (26) arranged in a chosen pattern along its face (12). Similarly, the donor assembly includes a number of open-top donor receptacles (38) arranged along its face (10) in a mirror image of the chosen pattern. The test membrane is captured between the receiver and donor faces. The drug diffuses through the test membrane and into the receiver liquid (53) during an incubation period (62). Samples (66) of the receiver liquid are preferably automatically transferred to a conventional microtiter plate (70) using a programmed liquid transfer system for assay by a scintillation counter (76).

摘要翻译： 用于通过测试膜（8）测试车辆内的药物扩散的扩散测试装置（2）包括彼此固定的接收器组件（6）和供体组件（4）。 接收器组件包括沿着其表面（12）以选定的图案布置的多个敞开式接收器插座（26）。 类似地，施主组件包括沿所选择的图案的镜像沿着其面（10）布置的多个开顶施主插座（38）。 测试膜被捕获在接收器和供体面之间。 在潜伏期（62）期间，药物通过测试膜扩散入接收液体（53）。 接收液体的样品（66）优选使用编程的液体转移系统自动转移到常规微量滴定板（70），以便通过闪烁计数器（76）进行测定。

公开(公告)号：US4578244A

公开(公告)日：1986-03-25

申请号：US371248

申请日：1982-04-23

申请人： Robert J. Cosgrove, Jr. ,  Victor F. Smolen

发明人： Robert J. Cosgrove, Jr. ,  Victor F. Smolen

IPC分类号： G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  G01N35/02

CPC分类号： G01N13/00 ,  G01N35/026 ,  G01N2013/006 ,  G01N2035/00198 ,  G01N2035/00752 ,  G01N33/15 ,  Y10S366/605

摘要： A sampling apparatus for obtaining a plurality of fluid samples is disclosed, such sampling apparatus being particularly useful in connection with dissolution testing of various products. The apparatus includes a plurality of sampling containers each having a chamber therein for receipt of a fluid, and a drive device for simultaneously moving the plurality of sample containers to a sampling station. First fluid conduits are provided for each of the sampling containers for conducting a fluid into each of the sampling containers when the sampling containers are positioned at the sampling station, and second fluid conduits are provided for each of the sampling containers for withdrawing a sample fluid from each of the sampling containers when the sampling containers are positioned at the sampling station. Devices are provided for coupling the first and second fluid conduits with the chambers of each of the sampling containers when the sampling containers are positioned at the sampling station, such devices in addition being adapted to individually seal the chambers of each of the sampling chambers when the first and second fluid conduits are coupled thereto. In the preferred embodiment, each of the sampling containers also includes an agitation element for agitating fluid introduced into the containers at the sampling station.

摘要翻译： 公开了一种用于获得多个流体样品的取样装置，这种采样装置在各种产品的溶出试验中特别有用。 该装置包括多个采样容器，每个采样容器各自具有用于接收流体的室，以及用于同时将多个样品容器移动到采样站的驱动装置。 为每个采样容器提供第一流体管道，用于当采样容器位于采样站时将流体导入每个采样容器中，并为每个采样容器提供第二流体管道，以将样品流体从 当采样容器位于采样站时，每个采样容器。 设备被提供用于当采样容器位于采样站时将第一和第二流体导管与每个采样容器的腔室联接，此外，这些装置还适于单独地密封每个采样室的腔室 第一和第二流体导管联接到其上。 在优选实施例中，每个采样容器还包括用于搅拌引入到采样站的容器中的流体的搅拌元件。

公开(公告)号：US4335438A

公开(公告)日：1982-06-15

申请号：US141093

申请日：1980-04-17

申请人： Victor F. Smolen

发明人： Victor F. Smolen

IPC分类号： G01N33/15 ,  G01N13/00 ,  G01N35/00 ,  G06F15/46 ,  G01N31/00

CPC分类号： G01N13/00 ,  G01N2013/006 ,  G01N2035/00198 ,  G01N33/15

摘要： A method and apparatus for optimally performing dissolution testing of pharmaceutical dosage forms, agricultural products, and components of industrial products wherein the method uses dissolution profiles from a known drug dosage form, or product, as reference data for a predictive process; and the apparatus is organized to carry out the method via both closed loop and open loop operating modes under the control of a central processor. An illustrative embodiment teaches the serial usage of the two operating modes in a single flow-through dissolution cell configuration to optimally predict the time course of in vivo bioavailability from in vitro dissolution measurements, while an alternate embodiment teaches the use of a plurality of dissolution cells and the simultaneous use of the closed and open loop operating modes to implement an Internal Standard capability. Additionally, an optimally adaptive capability is provided in the dissolution testing process via a random input modeling mode of operation.

摘要翻译： 用于最佳地进行药物剂型，农产品和工业产品组分的溶出度测试的方法和装置，其中所述方法使用来自已知药物剂型或产品的溶出曲线作为预测过程的参考数据; 并且该装置被组织以在中央处理器的控制下经由闭环和开环操作模式执行该方法。 说明性实施例教导了在单个流通溶解细胞构型中的两种操作模式的连续使用，以从体外溶出度测量最佳地预测体内生物利用度的时间过程，而替代实施方案教导了使用多个溶解细胞 同时使用闭环和开环操作模式来实现内部标准功能。 另外，通过随机输入建模操作模式在溶出度测试过程中提供最佳适应能力。

公开(公告)号：US3618395A

公开(公告)日：1971-11-09

申请号：US3618395D

申请日：1970-04-09

申请人： WELSH ,  GUIDO W MELLIGER

发明人： MELLIGER GUIDO W

IPC分类号： G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  G04F8/00 ,  G01N19/00

CPC分类号： G01N13/00 ,  G01N27/07 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00198 ,  G04F8/00

摘要： THIS INVENTION PROVIDES AN IMPROVEMENT IN A TABLET DISINTEGRATING APPARATUS, BY PROVIDING A PLURALITY OF OPPOSED SPACED ELECTRODES AT THE BASE OF THE TABLET CONTAINING TUBES. IN THE OPERATION OF THE APPARATUS AN ELECTRIC FIELD IS SET UP BETWEEN THE ELECTRODES. THE PRESENCE OF A TABLET DISTURBS THIS ELECTRIC FIELD, WHICH DISTURBANCE ACTUATES A RECORDING DEVICE SUCH AS A TIMER. THE CONVENTIONAL RECIPROCATING VERTICAL MOTION OF THE APPARTUS (IN AN AQUEOUS BATH) CAUSES THE TABLET TO DISINTEGRATE. AT THE END POINT OF THE TABLET DISINTEGRATION, THE UNDISTURBED FLOW OF CURRENT BETWEEN THE ELECTRODES STOPS THE RECORDING DEVICE, NOTING THE INTERVAL OF TIME FOR TABLET DISINTEGRATING

公开(公告)号：US3572648A

公开(公告)日：1971-03-30

申请号：US3572648D

申请日：1969-06-13

申请人： WILLIAM A HANSON

发明人： HANSON WILLIAM A

IPC分类号： G01N13/00 ,  G01N33/15 ,  G01N35/00 ,  B01F9/00

CPC分类号： G01N13/00 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00198

摘要： A basket stirrer for testing the dissolution rate of solid pharmaceutical preparations such as tablets and capsules. Passage means is provided through the drive plug which forms a closure at the upper end of the generally cylindrical screen basket to break the air or fluid lock which otherwise introduces errors in the routine laboratory use of this type of equipment by preventing proper fluid drainage from the basket when it is raised out of the testing solution at the end of a test, or proper circulation of the fluid through the basket during the test.

公开(公告)号：US20160327466A1

公开(公告)日：2016-11-10

申请号：US15103938

申请日：2014-12-05

申请人： SOTAX AG

发明人： GILLES KALBERMATTEN ,  Rolf Benz

IPC分类号： G01N13/00 ,  B01F1/00 ,  H04N5/225 ,  B01F13/10 ,  G01N33/15 ,  H04N5/247

CPC分类号： G01N13/00 ,  B01F1/0038 ,  B01F7/161 ,  B01F13/1022 ,  B01F2215/0032 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00198 ,  H04N5/2256 ,  H04N5/247

摘要： An apparatus (1) for dissolution testing comprises a tank (2) having a circular cylindrical outer body portion (21) with a transparent side wall and a circular cylindrical inner body portion (22) with a transparent side wall, wherein the inner body portion (22) is coaxially arranged with respect to the outer body portion (21) such that an outer interior (23) having a ring-shaped cross section is defined between the outer body portion (21) and the inner body portion (22) and an inner interior (24) having a circular cross section is defined inside the inner body portion. The apparatus (1) further comprises a plurality of dissolution vessels (4) arranged in the outer interior (23) of the tank and a heater assembly being arranged to heat a test media in the vessels (4) to a predefined temperature. The apparatus (1) according to the invention allows for a comparably precise monitoring of vessels (4) inside the tank (2) and/or an appropriate manipulation of the vessels (4) inside the tank (2).

摘要翻译： 一种用于溶出试验的装置（1）包括具有透明侧壁的具有圆筒形外主体部分（21）的罐（2）和具有透明侧壁的圆柱形内主体部分（22），其中内体部分 （22）相对于外主体部分（21）同轴布置，使得在外主体部分（21）和内主体部分（22）之间限定具有环形横截面的外部内部（23）和 具有圆形横截面的内部内部（24）被限定在内部主体部分内部。 装置（1）还包括布置在罐的外部内部（23）中的多个溶解容器（4），以及加热器组件，其布置成将容器（4）中的测试介质加热至预定温度。 根据本发明的装置（1）允许相对精确地监测罐（2）内部的容器（4）和/或适当地操纵罐（2）内的容器（4）。

公开(公告)号：US09285353B1

公开(公告)日：2016-03-15

申请号：US14925011

申请日：2015-10-28

申请人： Rohm and Haas Company

发明人： Lyn Hughes ,  Donald Frederick Wright

IPC分类号： G01N33/15

CPC分类号： G01N33/15 ,  B01F13/1013 ,  G01N1/18 ,  G01N2013/006 ,  G01N2035/00198 ,  Y10T436/255

摘要： Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates.

公开(公告)号：US08518327B2

公开(公告)日：2013-08-27

申请号：US13437414

申请日：2012-04-02

申请人： Colin B. Kennedy ,  Syed Husain ,  Dale von Behren ,  Rick Bernal

发明人： Colin B. Kennedy ,  Syed Husain ,  Dale von Behren ,  Rick Bernal

IPC分类号： G01N21/00

CPC分类号： G01N1/38 ,  G01N13/00 ,  G01N33/15 ,  G01N35/025 ,  G01N2013/003 ,  G01N2013/006 ,  G01N2035/00198

摘要： The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.

摘要翻译： 本发明提供了用于溶出度测试的系统和方法。 该系统包括多个溶解容器和位于溶解容器上方的剂量载体。 剂量载体保持多个可移除的转盘，其接收单独的剂量以进行溶解测试。 接收片剂或沉降片的转盘通常具有第一配置，而接收篮子的转盘通常具有第二配置。 转盘的两种不同配置可在相同的剂量环上互换。 所述系统还包括位于所述剂量载体上方的驱动头，所述驱动头具有篮状心轴和可移除地且可互换地连接的混合桨。 与系统整合的移液器将样品等分试样从溶出容器转移至50ml至1ml的范围至外部容器的孔。

公开(公告)号：US20090155920A1

公开(公告)日：2009-06-18

申请号：US12269508

申请日：2008-11-12

申请人： Eric D. Carlson

发明人： Eric D. Carlson

IPC分类号： G01N21/00 ,  G01N21/75 ,  G01N31/02 ,  G01N1/18

CPC分类号： G01N21/11 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00756 ,  B01J2219/00759 ,  B01L3/5025 ,  B01L3/5085 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N33/15 ,  G01N2035/00198 ,  Y10T436/25375 ,  Y10T436/255

摘要： A dissolution and precipitation system includes an array of reactors. Each reactor has a mother well and a daughter well having a volume between about one microliter and one milliliter. A fluid transfer system is operable to transfer fluid between the mother well and daughter well and purify the fluid that is transferred to the daughter well from the mother well. A method of testing a plurality of samples includes dissolving a plurality of first solids in each of the mother wells to form a plurality of first solutions in the mother wells. The first solutions are purified in the reactors. The first solutions are distributed from the mother wells to one or more daughter wells. A plurality of second solids are precipitated in the daughter wells and the second solids are analyzed.

摘要翻译： 溶解和沉淀系统包括一系列反应器。 每个反应器具有母体阱和具有约1微升至1毫升之间体积的母体。 流体输送系统可操作以在母井和子宫之间传输流体并净化从母井转移到子女的流体。 测试多个样品的方法包括将多个第一固体溶解在每个母井中以在母井中形成多个第一溶液。 第一溶液在反应器中纯化。 第一个解决方案从母井分配到一个或多个子孔。 多个第二固体在子孔中沉淀，并分析第二固体。