公开(公告)号：US20070037221A1

公开(公告)日：2007-02-15

申请号：US11418598

申请日：2006-05-05

Applicant: Timothy Block ,  Mary Comunale ,  Anand Mehta

Inventor： Timothy Block ,  Mary Comunale ,  Anand Mehta

IPC: G01N33/567 ,  G01N33/53

CPC classification number: G01N33/6893 ,  G01N33/57438 ,  G01N2333/4728 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/7028

Abstract: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

Abstract translation: 公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。 所述方法包括定量检测生物流体中的蛋白质上的糖基化，更具体地岩藻糖基化，并将检测到的糖基化与在健康或疾病状态下这些蛋白质糖基化的参考值进行比较。

公开(公告)号：US20060104265A1

公开(公告)日：2006-05-18

申请号：US10987381

申请日：2004-11-12

Applicant: Timothy Block ,  Yu-Cheng Hsu ,  John McCauley ,  Sean Riley ,  William Sherman ,  Cheng-Chung Song

Inventor： Timothy Block ,  Yu-Cheng Hsu ,  John McCauley ,  Sean Riley ,  William Sherman ,  Cheng-Chung Song

IPC: H04L12/50

CPC classification number: H04L41/08 ,  H04L41/0803 ,  H04L43/0811

Abstract: Provided are a method, system, and program for configuring shared devices over a fabric. A module in a first processing complex configures a first part of a fabric enabling communication with a set of devices accessible through the first part of the fabric. The module detects a located device accessible through a second part of the fabric, wherein a second processing complex is designated to configure the second part of the fabric and the located device. The module determines whether the second processing complex is available in response to detecting the uninitialized device. The module passes to a device driver in the first processing complex an uninitialized property for the located device. The device driver requests the module to configure the second part of the fabric to enable access to the located device over the second part of the fabric in response to determining that the located device has the uninitialized property.

Abstract translation: 提供了一种用于通过结构配置共享设备的方法，系统和程序。 第一处理复合体中的模块配置结构的第一部分，使得能够通过该结构的第一部分可访问的一组设备进行通信。 模块检测通过织物的第二部分可访问的定位设备，其中指定第二处理复合体以配置织物的第二部分和定位的设备。 该模块响应于检测到未初始化的设备来确定第二处理复合体是否可用。 该模块在第一个处理组合中传递给设备驱动程序，用于定位设备的未初始化属性。 所述设备驱动程序响应于确定所述定位的设备具有未初始化的属性，请求所述模块配置所述结构的所述第二部分以允许通过所述结构的第二部分访问所位于的设备。

公开(公告)号：US20060094671A1

公开(公告)日：2006-05-04

申请号：US11300464

申请日：2005-12-15

Applicant: Gary Jacob ,  Timothy Block ,  Raymond Dwek

Inventor： Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC: A61K31/7076 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/445

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K45/06

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

公开(公告)号：US20050246570A1

公开(公告)日：2005-11-03

申请号：US11154228

申请日：2005-06-16

Applicant: Timothy Block ,  Kiswanto Thayib

Inventor： Timothy Block ,  Kiswanto Thayib

IPC: G06F11/00 ,  G06F15/16

CPC classification number: H04L69/16 ,  H04L12/18 ,  H04L69/166 ,  H04L69/24

Abstract: An apparatus, program product and method support the dynamic modification of cluster communication parameters such as a fragmentation size parameter through controllably deferring the processing of a requested fragmentation size change in a source node until after receipt an acknowledgment message for at least one unacknowledged message sent by the source node to a plurality of target nodes. By controllably deferring such processing until it is confirmed that any such previously-unacknowledged messages sent by a source node have been received by any target nodes, synchronization between the source node and the target nodes may be obtained, and a fragmentation size change may occur in a coordinated fashion such that future messages from the source node to the target node will be processed by both the source and the target nodes using the modified fragmentation size parameter.

公开(公告)号：US20050053625A1

公开(公告)日：2005-03-10

申请号：US10494377

申请日：2002-10-30

Applicant: Timothy Block ,  Anand Mehta ,  Raymond Dwek

Inventor： Timothy Block ,  Anand Mehta ,  Raymond Dwek

IPC: A61K31/445 ,  A61K38/16 ,  A61K39/29

CPC classification number: A61K31/445 ,  A61K38/162 ,  A61K39/12 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/5258 ,  C12N2730/10134 ,  A61K2300/00

Abstract: The present invention relates to the treatment of viral infections, particularly HBV and HCV infections, with a combination comprising a vaccine against a virus antigen and compounds that inhibit glucosidase activity in the host cell.

Abstract translation: 本发明涉及包含针对病毒抗原的疫苗和抑制宿主细胞中的葡糖苷酶活性的化合物的组合的病毒感染，特别是HBV和HCV感染的治疗。

公开(公告)号：US20050267153A1

公开(公告)日：2005-12-01

申请号：US10910197

申请日：2004-08-03

Applicant: Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

Inventor： Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC: A61K31/445 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K45/06 ,  A61P1/16 ,  A61P31/20 ,  C07D211/46 ,  C07H19/10

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K45/06

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

Abstract translation: 提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。 方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或 （2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

公开(公告)号：US20050112711A1

公开(公告)日：2005-05-26

申请号：US10934520

申请日：2004-09-03

Applicant: Patrick Romano ,  Timothy Block ,  Claus Fimmel ,  Olga Nikolaeva

Inventor： Patrick Romano ,  Timothy Block ,  Claus Fimmel ,  Olga Nikolaeva

IPC: G01N20060101 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/574

CPC classification number: G01N33/57438

Abstract: Elevated levels of GP73 in the sera is diagnostic for hepatocellular carcinoma. An increase in serum GP73 levels over time can also indicate the onset of hepatocellular carcinoma in subjects at risk for the disease.

Abstract translation: 血清中GP73水平升高是肝细胞癌的诊断。 随着时间的推移，血清GP73水平的增加也可能表明患有该疾病风险的受试者的肝细胞癌发病。

公开(公告)号：US20050021751A1

公开(公告)日：2005-01-27

申请号：US10626086

申请日：2003-07-24

Applicant: Timothy Block ,  Bob Cernohous ,  John Unterholzner

Inventor： Timothy Block ,  Bob Cernohous ,  John Unterholzner

IPC: G06F15/173 ,  G06F9/46 ,  G06F11/00 ,  G06F11/20 ,  H04L29/08

CPC classification number: G06F11/2041 ,  G06F9/54 ,  G06F11/1482 ,  G06F11/2007 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/1017 ,  H04L67/1023 ,  H04L67/1034

Abstract: An apparatus, program product and method utilize cluster data port services within a cluster infrastructure to provide reliable and efficient communications between nodes in a clustered computer system. The cluster data port services present an abstracted transport service that encapsulates and manages the establishment of multiple connection paths between a source node, a target node and one or more backup nodes in such a manner that a cluster data port is effectively utilized as single data port from the perspective of a user program.

Abstract translation: 一种装置，程序产品和方法利用集群基础设施内的集群数据端口服务来提供群集计算机系统中的节点之间的可靠和有效的通信。 集群数据端口服务呈现抽象传输服务，其以这样的方式封装和管理在源节点，目标节点和一个或多个备份节点之间建立多个连接路径，使得集群数据端口被有效地用作单个数据端口 从用户程序的角度。