Patent search ap:"UNIVERSITE PARIS DESCARTES" Page 2

11.

发明申请
METHOD AND DEVICE FOR PROCESSING AT LEAST ONE IMAGE OF A GIVEN PART OF AT LEAST ONE LUNG OF A PATIENT 审中-公开

公开(公告)号：US20200051240A1

公开(公告)日：2020-02-13

申请号：US16339615

申请日：2017-10-04

Applicant: UNIVERSITE PARIS DESCARTES , INTRASENSE , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

Inventor： Guillaume CHASSAGNON , Marie-Pierre REVEL , Stéphane CHEMOUNY , Amandine RENÉ

IPC: G06T7/00 , A61B6/03 , A61B6/00 , G06T7/11 , G06T7/162 , G06T7/62

Abstract: The invention relates to a method for automatically processing at least one image slice of a given part of at least one lung of a patient suffering from a pathology that causes a bronchial infection by diffuse dilatation of the bronchial tubes of the lungs, the method comprising steps of segmenting (102) the at least one image slice of the given part of the lung, in order to produce a histogram characterising the pulmonary density of the given part of the lunch, by means of the voxels of the at least one image slice, each voxel being assocaited with a given pulmonary density; calculating (104) a threshold, from the histogram, corresponding to a threshold pulmonary density, based on at least one characteristic of the histogram, a first characteristic being the mode of the histogram; determining (106) from the at least one image slice of the given part of the lung, a pulmonary volume having a pulmonnar density higher or lower than the calculatedd threshold, corresponding to the sum of the voxels having a pulmonary density higher or lower than the calculated threshold; and calculating (110) an automatic score on the basis of the determined pulmonary volume, in order to monitor the evolution of the broncial infection of the patient.

12.

发明申请
Process For Determining The Infiltration Of Biological Cells In A Biological Object Of Interest 审中-公开

公开(公告)号：US20190392612A1

公开(公告)日：2019-12-26

申请号：US16431237

申请日：2019-06-04

Applicant: Centre National de la Recherche Scientifique (CNRS) , Universite Paris Descartes , Ecole Nationale Superieure de Chimie de Paris , Assistance Publique-Hopitaux de Paris , Universite De Versailles-St Quentin En Yvelines , Institut National de la Sante et de la Recherche Medicale (INSERM)

Inventor： Kathia Lemdani , Johanne Seguin , Armand Tiede Djiro , Jean-Francois Emile , Camille Kurtz , Nicolas Lomenie

IPC: G06T7/90 , G06K9/00

Abstract: The invention relates to a process for determining an infiltration profile of biological cells of interest in a biological object of interest from a digital histopathological image of biological tissues, a histological stain having previously been applied to the biological tissues, comprising generating a biological cell detection image, pixels associated with the histological stain on the histopathological image being of a predetermined color on said image, determining a distance map comprising distance iso-curves to the boundary of the biological object, and, from the distance map, calculating a curve representative of the surface density of biological cells of interest as a function of distance to the boundary, by counting, for each boundary distance value, pixels that are both of the predetermined color on the detection image and located between the iso-curve associated with said distance value and the consecutive iso-curve.

13.

发明申请
FACTOR H FRAGMENT FOR USE AS AN ANTI-ANGIOGENIC AGENT 审中-公开

公开(公告)号：US20190388506A1

公开(公告)日：2019-12-26

申请号：US16066963

申请日：2016-12-30

Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE PARIS DIDEROT - PARIS 7 , UNIVERSITE PARIS DESCARTES , LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

Inventor： Virginie DINET , Frédéric MASCARELLI , Toufik ABACHE , Sylvie JORIEUX

IPC: A61K38/17 , A61P9/10

Abstract: The invention relates to a complement factor H fragment for use in the treatment and/or prophylaxis of a disease involving neovascularization.

14.

发明申请
MATERIALS COATED WITH CALIXARENES 审中-公开

公开(公告)号：US20190233358A1

公开(公告)日：2019-08-01

申请号：US16374887

申请日：2019-04-04

Applicant: UNIVERSITE LIBRE DE BRUXELLES (ULB) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE RENNES 1 , UNIVERSITE PARIS DESCARTES

Inventor： Ivan JABIN , Alice MATTIUZZI , Corinne LAGROST , Philippe HAPIOT , Olivia REINAUD

IPC: C07C43/21 , C08J7/04 , C07C43/225 , C07D333/50 , C07C217/94 , C07C205/37 , C07C69/736 , C07C59/72 , C07C245/20

CPC classification number: C07C43/21 , C07B2200/11 , C07C43/225 , C07C59/72 , C07C69/736 , C07C205/37 , C07C217/94 , C07C245/20 , C07C2603/90 , C07D333/50 , C08J7/04 , Y10T428/265

Abstract: This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process.

15.

发明授权
Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases 有权

公开(公告)号：US10323078B2

公开(公告)日：2019-06-18

申请号：US15559984

申请日：2016-03-21

Applicant: Universite Paris Descartes , Assistance Publique—Hopitaux de Paris , Universite Paris—SUD , Unviversite Pierre et Marie Curie (Paris 6) , Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Institut Gustave-Roussy

Inventor： Nicolas Dupin , Philippe Grange , Vincent Calvez , Joël Raingeaud

IPC: C07K14/75 , A61P17/10 , A61P17/06 , A61P29/00 , A61K9/00 , C12N7/00 , A61K38/00

Abstract: A present invention relates to isolated peptides obtained from human fibrinogen for their use as drug, particularly for the prevention and/or the treatment of inflammatory skin diseases, more particularly acne. The present invention also relates to fragments of these polypeptides, nucleic acid molecules encoding them, expression vectors, host cells, a pharmaceutical composition and a combination product containing them, and their use for treating and/or preventing inflammatory skin diseases, particularly acne.

16.

发明申请
LYOPHILIZED COMPOSITION FOR PRESERVING MICROBIOTA IN ITS ECOSYSTEM 审中-公开

公开(公告)号：US20190134110A1

公开(公告)日：2019-05-09

申请号：US16062302

申请日：2016-12-16

Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , UNIVERSITE PARIS DESCARTES , UNIVERSITE PARIS DIDEROT - PARIS 7 , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Inventor： Nathalie Kapel , Anne-Judith Waligora-Dupriet , Muriel Thomas , Christine Charrueau , Francisca Joly , Camille Mayeur , Véronique Robert , Johanne Delannoy

IPC: A61K35/741 , A61K9/19

Abstract: The invention relates to a lyophilized composition comprising a microbiota in its ecosystem, in particular stools, and a mixture of cryoprotectant agents comprising maltodextrin and trehalose, a capsule comprising said lyophilized composition, the use thereof, and methods for the production thereof.

17.

发明授权
Use of compounds inhibiting apelin / APJ / GP130 signaling for treating cancer 有权

公开(公告)号：US10247722B2

公开(公告)日：2019-04-02

申请号：US15127534

申请日：2015-03-20

Applicant: Centre National de la Recherche Scientifique (CNRS) , Universite Paris Descartes , Institut National de la Sante et de la Recherche Medicale (INSERM)

Inventor： Julie Gavard , Eva-Maria Galan-Moya

IPC: G01N33/53 , G01N33/50 , G01N33/574 , A61K39/395 , A61K48/00 , A61K31/00 , C12N15/113

Abstract: Today, despite current advances in combinatorial therapies such as surgery, radiotherapy and chemotherapy, aggressive cancers remain fatal. Cancer stem-like cells (CSCs) may account for chemotherapy resistance and thus represent a promising therapeutic target. In this context, the present inventors identified essential intracellular pathways favoring the self-renewal and survival of CSCs. More precisely, the present inventors showed that the cytokine co-receptor GP130 acts as a co-receptor for Apelin/APJ signaling and that the interaction of Apelin with APJ/GP130 activates a dual signaling pathway involving the Akt/mTOR and STAT3 transcription factor, thereby promoting CSCs survival and self-renewal. They therefore propose to block these pathways in order to treat patients suffering from tumors containing CSCs, such as glioblastomas. In another aspect, the invention relates to the use of the Apelin expression level for evaluating the survival probability of a subject suffering from glioblastoma.

18.

发明申请
METHODS FOR THE DIAGNOSTIC OF AN AUTOIMMUNE DISEASE 审中-公开

公开(公告)号：US20190056392A1

公开(公告)日：2019-02-21

申请号：US16143896

申请日：2018-09-27

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT CURIE , UNIVERSITE PARIS DESCARTES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Eliane PIAGGIO , Louis PEROL

IPC: G01N33/564 , G01N33/00 , C07K14/55 , C07K16/24 , C07K14/47

Abstract: An in vitro method for determining whether a patient has, or is at risk of having or developing an autoimmune disease or for assessing the severity or predicting the outcome of an autoimmune disease, comprising a step of detecting or quantifying in a biological sample obtained from said patient an immune anti-IL2 response, peptides specifically recognised by anti-1L2 antibodies or IL-2-specific T cells of T1D, systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome and autoimmune polymyositis patients, and pharmaceutical compositions.