-
公开(公告)号：US20250084416A1
公开(公告)日：2025-03-13
申请号：US18728870
申请日：2022-09-19
Inventor： Song Li , Yuang Chen
IPC: C12N15/113 , A61K47/60 , A61K47/61 , A61K47/64
Abstract: A therapeutic system or combination includes a first therapeutic agent to treat a disease condition and a second therapeutic agent adnrinistrable within a predetermined time of administration of the first therapeutic agent the second therapeutic agent inhibiting the function of Xkr8.
-
公开(公告)号：US20250082728A1
公开(公告)日：2025-03-13
申请号：US18956193
申请日：2024-11-22
Inventor： Alexis Lauren NOLFI , Bryan Nicklaus BROWN , Mangesh KULKARNI , Vishal JHANJI
IPC: A61K38/20 , A61K9/00 , A61K31/726 , A61K47/64 , A61P27/02
Abstract: Described here are ophthalmic compositions and methods for treatment of dry eye disease. One ophthalmic composition includes an effective amount of interleukin-4 (IL-4) in a free uncomplexed form, or as a complex with a dermatan sulfate. A second ophthalmic composition includes an effective amount of interleukin-13 (IL-13) in a free uncomplexed form, or as a complex with a dermatan sulfate. A third ophthalmic composition includes effective amounts of IL-4 and IL-13 in a free uncomplexed form, or as a complex with a dermatan sulfate. A fourth ophthalmic composition includes at least one activator of interleukin-4 receptor signaling in a free uncomplexed form, or as a complex with a dermatan sulfate.
-
公开(公告)号：US12246049B2
公开(公告)日：2025-03-11
申请号：US18452307
申请日：2023-08-18
Inventor： Stephen Howard Thorne , Daniel J. Byrd
IPC: A61K35/768 , A61K9/00 , A61P35/00 , C07K14/07 , C07K14/16 , C07K14/47 , C12N9/10 , C12N9/16 , C12N15/62 , C07K16/28
Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
-
公开(公告)号：US20250042983A1
公开(公告)日：2025-02-06
申请号：US18717623
申请日：2022-12-09
Inventor： Debasish SINHA , Urvi GUPTA , Sayan GHOSH , Peng SHANG , Stacey HOSE , Nadezda Anatolyevna STEPICHEVA , Jose Alain SAHEL
Abstract: Disclosed are monoclonal antibodies, and antigen binding portions thereof, which neutralize human Lipocalin 2 (LCN-2). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also disclosed. Related methods of reducing or preventing ferroptotic death of retinal pigmented epithelium (RPE) cells, methods of reducing or preventing one or both of lipid peroxidation and inflammasome activation in RPE cells, methods of reducing or preventing a decrease in one or both of scotopic a- and b-wave responses in a retina, methods of increasing one or both of scotopic a- and b-wave responses in a retina, methods of increasing one or both of autophagy and glutathione peroxidase activity in RPE cells, and methods of treating or preventing age-related macular degeneration (AMD) are also disclosed.
-
公开(公告)号：US12214150B2
公开(公告)日：2025-02-04
申请号：US17611486
申请日：2020-05-15
Inventor： Louis D. Falo, Jr. , Emrullah Korkmaz
Abstract: The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.
-
Patent Agency Ranking
公开(公告)号：US12213800B2
公开(公告)日：2025-02-04
申请号：US18206401
申请日：2023-06-06
Inventor： Alexander Star , Sean Ihn Young Hwang
IPC: A61B5/1477 , A61B5/00 , A61B5/08 , A61B5/097 , A61B5/1455 , C01B32/159 , C01B32/198 , G01N33/94
Abstract: A device for detection of a cannabinoid in a sample includes a sensor including a substrate and a sensor medium on the substrate. The sensor medium includes at least one nanostructure, wherein at least one property of the sensor medium is dependent upon the presence of the cannabinoid on a surface of the sensor medium. The device further includes electronic circuitry including at least one measurement system in operative connection with the sensor to measure a variable relatable to the at least one property of the sensor medium dependent upon the presence of the cannabinoid.
-
公开(公告)号：US20250032044A1
公开(公告)日：2025-01-30
申请号：US18714863
申请日：2023-03-30
Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , NORTHEASTERN UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS
Inventor： Murat Akcakaya , Deniz Kocanaogullari , Emily Grattan , George F. Wittenberg , Jennifer Mak , Sarah Ostadabbas , Xiaofei Huang
Abstract: A method of determining an extent of visual spatial neglect of a patient includes providing a software-based test to the patient via a presentation apparatus positioned on the head of the patient and having a display device positioned close and in front of the eyes of the patient. EEG information is collected from the patient during the test via an EEG apparatus positioned on the head of the patient. Portions of the EEG information collected during the test are used to determine the extent of the visual spatial neglect of the patient. An indication of the extent of the visual spatial neglect of the patient is provided.
-
18.发明授权公开(公告)号：US12188019B2
公开(公告)日：2025-01-07
申请号：US17144365
申请日：2021-01-08
Inventor： Ramon Bataller Alberola , Jose Maria Argemi Ballbe
IPC: C12N15/113
Abstract: Provided herein are antisense agents for knocking down, inhibiting, or silencing expression of an HNF4α-P2 isoform mRNA in a cell or a patient. Also provided are methods of knocking down, inhibiting, or silencing expression of an HNF4α-P2 isoform mRNA in a cell or a patient and methods of treating a patient with liver disease, liver damage, liver inflammation, or liver failure, such as acute liver failure, ALD, AH, or ACLF.
-
公开(公告)号：US20250002549A1
公开(公告)日：2025-01-02
申请号：US18817667
申请日：2024-08-28
Inventor： Alan H. Wells
Abstract: Recombinant C-X-C motif chemokine ligand (CXCL) peptides modified to introduce a cleavage site for a protease, such as a protease activated during an inflammatory response, are described. The CXCL peptides have the capacity to activate CXCR3 until being cleaved by the protease. Proteolytic cleavage of the CXCL peptide minimizes the pro-inflammatory response and inhibits the development of fibrosis.
-
公开(公告)号：US20250001111A1
公开(公告)日：2025-01-02
申请号：US18579025
申请日：2022-07-14
Inventor： Carl H. Snyderman , Nikki Cwalina , Brinden Elton , Maxwell Baxter , Garrett N. Coyan
Abstract: Disclosed herein are endotracheal tubes that have multiple inflatable cuffs to help form a seal for ventilation, to reduce unwanted migration of the tube relative to the patient, reduce focalized pressure from a single cuff, and to help prevent aspiration of materials between the outside of the tube and the tracheal walls. Some devices include first and second distal cuffs for placement within the trachea and a proximal third cuff for blocking the entrance to the trachea. The cuffs can include ridges or textures to enhance sealing. The device can also include inflation channels, vacuum channels, and pressure sensors.
-
-
-
-
-
-
-
-
-
Search Results
2329
records
(took 0.037 seconds)
