NANOSTRUCTURE-BASED SENSORS AND METHODS FOR DETECTING ANTIGENS AND ANTIBODIES

    公开(公告)号:US20220365078A1

    公开(公告)日:2022-11-17

    申请号:US17739800

    申请日:2022-05-09

    IPC分类号: G01N33/543 G01N27/414

    摘要: A method of detecting an analyte in a fluid sample includes exposing a sensor including a substrate and a sensor medium on the substrate to the fluid sample for a period of time. The sensor medium includes a plurality of nanostructures and one or more of at least one agent selected from the group consisting of an antibody, an antigen receptor or an antigen immobilized upon at least a portion of the plurality of nanostructures. The at least one agent is an antibody or an antigen receptor if the analyte is an antigen and is an antigen if the analyte is an antibody. An electrolyte liquid having a known ionic strength which is less than the fluid sample is added over the sensor medium subsequent to exposing the sensor to the fluid and a variable providing a measure of change in at least one property of the sensor medium which is dependent upon the presence of the analyte is measured in presence of the electrolyte liquid.