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    Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
    14.
    发明申请
    Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same 审中-公开
    吡唑并吡啶甲酰胺衍生物和含有它们的磷酸二酯酶（pde）抑制剂

    公开(公告)号：US20100056791A1

    公开(公告)日：2010-03-04

    申请号：US12310562

    申请日：2007-08-30

    申请人： Yasushi Kohno ,  Koji Ochiai ,  Akihiko Kojima

    发明人： Yasushi Kohno ,  Koji Ochiai ,  Akihiko Kojima

    IPC分类号： C07D471/02

    CPC分类号： C07D471/04

    摘要： A novel pyrazolopyridine carboxamide derivative is provided that is useful as a pharmaceutical drug having phosphodiesterase inhibitory activity.The pyrazolopyridine carboxamide derivative is represented by the following general formula (1): (Example: 2-ethyl-7-methoxypyrazolo[1,5-a]pyridine-4-carboxylic acid (3,5-dichloropyridin-4-yl)amide).

    摘要翻译： 提供一种新颖的吡唑并吡啶羧酰胺衍生物，其可用作具有磷酸二酯酶抑制活性的药物。 吡唑并吡啶羧酰胺衍生物由以下通式（1）表示：（实施例：2-乙基-7-甲氧基吡唑并[1,5-a]吡啶-4-甲酸（3,5-二氯吡啶-4-基）酰胺 ）。

    AMINO PHOSPHATE DERIVATIVE AND S1P RECEPTOR MODULATOR HAVING SAME AS AN ACTIVE INGREDIENT
    15.
    发明申请
    AMINO PHOSPHATE DERIVATIVE AND S1P RECEPTOR MODULATOR HAVING SAME AS AN ACTIVE INGREDIENT 有权
    具有活性成分的氨基磷酸衍生物和S1P受体调节剂

    公开(公告)号：US20090325907A1

    公开(公告)日：2009-12-31

    申请号：US12310007

    申请日：2007-08-07

    申请人： Yasushi Kohno ,  Kiyoshi Fujii ,  Tatsuhiro Saito

    发明人： Yasushi Kohno ,  Kiyoshi Fujii ,  Tatsuhiro Saito

    IPC分类号： A61K31/661 ,  C07F9/06

    CPC分类号： C07F9/091

    摘要： To provide an amino phosphate derivative having an excellent sphingosine-1-phosphate (S1P) receptor modulatory action.As a result of continued intensive research to create a highly safe compound which has an S1P receptor modulatory action, is has been discovered that an amino phosphate derivative represented by the following general formula (1), has a strong S1P receptor modulatory action.

    摘要翻译： 提供具有优异的鞘氨醇-1-磷酸（S1P）受体调节作用的氨基磷酸酯衍生物。 作为继续深入研究以产生具有S1P受体调节作用的高度安全的化合物的结果，已经发现由以下通式（1）表示的氨基磷酸酯衍生物具有强的S1P受体调节作用。

    Pyrazolopyride derivative and phosphodiesterase ( pde) inhibitors containing the same as active ingredient
    16.
    发明申请
    Pyrazolopyride derivative and phosphodiesterase ( pde) inhibitors containing the same as active ingredient 审中-公开
    吡唑并吡啶衍生物和含有与活性成分相同的磷酸二酯酶（pde）抑制剂

    公开(公告)号：US20090318385A1

    公开(公告)日：2009-12-24

    申请号：US12310736

    申请日：2007-09-05

    申请人： Yasushi Kohno ,  Satoshi Takita ,  Akihiko Kojima ,  Tetsuya Kishi

    发明人： Yasushi Kohno ,  Satoshi Takita ,  Akihiko Kojima ,  Tetsuya Kishi

    IPC分类号： A61K31/695 ,  C07D471/04 ,  A61K31/437 ,  C07F7/02

    CPC分类号： C07D471/04

    摘要： A novel pyrazolopyridine derivative is provided which is useful as a pharmaceutical drug having phosphodiesterase inhibitory activity.The pyrazolopyridine derivative is represented by the following general formula (1): [wherein R1 is a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like, R2 is an optionally substituted alkyl group having 1 to 6 carbon atoms or the like, R5 and R6 are independently a hydrogen atom or a halogen atom, R13 is a hydrogen atom or a halogen atom, n is 0 or 1, is a single or double bond, R3 is a hydrogen atom, a hydroxyl group, or the like, and R4 is a hydrogen atom, a phenyl group, or the like] or a pharmaceutically acceptable salt thereof, and a hydrate thereof.

    摘要翻译： 提供一种新颖的吡唑并吡啶衍生物，其可用作具有磷酸二酯酶抑制活性的药物。 吡唑并吡啶衍生物由以下通式（1）表示：[其中R 1是氢原子，任选取代的具有1至6个碳原子的烷基等，R 2是任选取代的具有1至6个碳的烷基 原子等，R 5和R 6独立地为氢原子或卤素原子，R 13为氢原子或卤素原子，n为0或1，为单键或双键，R 3为氢原子，羟基 等，R 4为氢原子，苯基等]或其药学上可接受的盐及其水合物。

    FLOW MEASURING DEVICE
    18.
    发明申请
    FLOW MEASURING DEVICE 失效
    流量测量装置

    公开(公告)号：US20080289413A1

    公开(公告)日：2008-11-27

    申请号：US12120517

    申请日：2008-05-14

    申请人： Junzo Yamaguchi ,  Yasushi Kohno

    发明人： Junzo Yamaguchi ,  Yasushi Kohno

    IPC分类号： G01F1/692

    CPC分类号： G01F1/692

    摘要： According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

    摘要翻译： 根据流量测量装置，由第一多个电阻器形成的第一范围在流动方向坐标轴上形成单个连续值范围。 因此，第一多个电阻器被限制为在流动方向上彼此热绝缘，从而提高了检测性。 此外，由第二多个电阻器形成的第二范围在纵向坐标轴上形成另一个单个连续值范围。 另一连续值范围包括对应于加热元件在纵向上的半长度的位置。 结果，在最佳检测温度的位置处获得检测差异，从而进一步提高检测性。

    FLOW QUANTITY MEASURING DEVICE
    19.
    发明申请
    FLOW QUANTITY MEASURING DEVICE 有权
    流量测量装置

    公开(公告)号：US20080264154A1

    公开(公告)日：2008-10-30

    申请号：US12108313

    申请日：2008-04-23

    申请人： Junzo Yamaguchi ,  Yasushi Kohno

    发明人： Junzo Yamaguchi ,  Yasushi Kohno

    IPC分类号： G01F1/68 ,  G01M15/04

    CPC分类号： G01F1/692

    摘要： In a flow quantity measuring device, each of upstream side and downstream side sensing resistors, which are placed on an upstream side and a downstream side, respectively, of a heating resistor, includes resistor elements, each of which forms a folded path. The folded path has a generally constant width along an entire extent thereof and is returned at each of first and second longitudinal end edges of a sensing area. The heating resistor forms a folded path, which has a generally constant width along an entire extent thereof and is returned at the second longitudinal end edge of the heat generating area. First and second ends of the folded path of the heating resistor projects beyond the first longitudinal end edge of the sensing area on a first side of the flow quantity measuring device.

    摘要翻译： 在流量测量装置中，分别位于加热电阻器的上游侧和下游侧的上游侧和下游侧检测电阻器中的每一个包括各自形成折叠路径的电阻器元件。 折叠路径在其整个范围上具有大致恒定的宽度，并且在感测区域的第一和第二纵向端边缘的每一个处返回。 加热电阻器形成折叠路径，该折叠路径在其整个范围上具有大致恒定的宽度，并且在发热区域的第二纵向端部边缘处返回。 加热电阻器的折叠路径的第一和第二端在流量测量装置的第一侧突出超过感测区域的第一纵向端边缘。