公开(公告)号：US20100331940A1

公开(公告)日：2010-12-30

申请号：US12495612

申请日：2009-06-30

Applicant: Virote Indravudh ,  Yong D. Zhao ,  Kevin L. Morgan ,  Dion F. Davis ,  Grace Jang

Inventor： Virote Indravudh ,  Yong D. Zhao ,  Kevin L. Morgan ,  Dion F. Davis ,  Grace Jang

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/086

Abstract: An implantable medical lead configured for improved MRI safety and heating reduction performance is disclosed herein. In one embodiment, the lead includes a tubular body having a proximal end and a distal end with a lead connector near the proximal end. In this embodiment the lead further includes a conductor extending longitudinally within the tubular body and having a proximal end that is electrically coupled to the connector and a distal end electrically coupled to a contact pin. The lead in this embodiment further includes a filter element electrically coupled to a distal end of the contact pin and a flange electrically coupled between a proximal end of the filter element and a proximal portion of an electrode. In this embodiment the flange and the proximal portion of the electrode form at least a first part of a hermetic chamber enclosing the filter element.

Abstract translation: 本文公开了一种被配置用于改善MRI安全性和加热降低性能的可植入医疗引线。 在一个实施例中，引线包括具有近端和远端的管状体，其具有靠近近端的引线连接器。 在该实施例中，引线还包括在管状体内纵向延伸的导体，并且具有电连接到连接器的近端和电耦合到接触销的远端。 该实施例中的引线还包括电耦合到接触针的远端的过滤元件和电耦合在过滤元件的近端和电极的近端部分之间的凸缘。 在该实施例中，电极的凸缘和近端部分形成封闭过滤元件的密封室的至少第一部分。

公开(公告)号：US08634931B2

公开(公告)日：2014-01-21

申请号：US12262047

申请日：2008-10-30

Applicant: Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

Inventor： Xiaoyi Min ,  J. Christopher Moulder ,  Yong D. Zhao ,  Virote Indravudh ,  Ingmar Viohl

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/086 ,  H01F17/00

Abstract: An implantable medical lead is disclosed herein. In one embodiment, the lead includes a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and include a coiled inductor including a first portion and a second portion at least partially magnetically decoupled from the first portion. The first portion may include a first configuration having a first SRF. The second portion may include a second configuration different from the first configuration. The second configuration may have a second SRF different from the first SRF. For example, the first SRF may be near 64 MHz and the second SRF may be near 128 MHz.

Abstract translation: 本文公开了可植入医疗引线。 在一个实施例中，引线包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸，并且包括线圈电感器，其包括至少部分地与第一部分磁耦合的第一部分和第二部分。 第一部分可以包括具有第一SRF的第一配置。 第二部分可以包括不同于第一配置的第二配置。 第二配置可以具有与第一SRF不同的第二SRF。 例如，第一SRF可以接近64MHz，而第二SRF可以接近128MHz。

公开(公告)号：US08573062B2

公开(公告)日：2013-11-05

申请号：US13365005

申请日：2012-02-02

Applicant: Yong D. Zhao ,  Apratim Dixit

Inventor： Yong D. Zhao ,  Apratim Dixit

IPC: G01L7/00 ,  A61N1/365 ,  A61B5/0215 ,  A61B5/00 ,  G01L9/00

CPC classification number: A61B5/0215 ,  A61B5/686 ,  A61B5/6869 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/028 ,  A61N1/056 ,  A61N1/3702 ,  G01L9/0073 ,  G01L27/002

Abstract: The disclosure relates in some aspects to an implantable pressure sensor and a method of measuring pressure. In some embodiments pressure may be measured through the use of an implantable lead incorporating one or more pressure sensors. In some aspects a pressure sensor is implemented in a micro-electromechanical system (“MEMS”) that employs direct mechanical sensing. A biocompatible material is attached to one or more portions of the MEMS sensor to facilitate implant in a body of a patient. The MEMS sensor may thus be incorporated into an implantable lead for measuring blood pressure in, for example, one or more chambers of the patient's heart.

Abstract translation: 本公开在一些方面涉及可植入压力传感器和测量压力的方法。 在一些实施例中，可以通过使用结合有一个或多个压力传感器的可植入引线来测量压力。 在一些方面，在采用直接机械感测的微机电系统（“MEMS”）中实现压力传感器。 生物相容性材料附接到MEMS传感器的一个或多个部分以便于植入患者体内。 因此，MEMS传感器可以被结合到可植入引线中，用于测量例如患者心脏的一个或多个腔室中的血压。

公开(公告)号：US08538553B2

公开(公告)日：2013-09-17

申请号：US12889189

申请日：2010-09-23

Applicant: Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

Inventor： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/086

Abstract: An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.

Abstract translation: 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。

公开(公告)号：US20120134520A1

公开(公告)日：2012-05-31

申请号：US13286642

申请日：2011-11-01

Applicant: Yong D. ZHAO ,  Jennifer Jinping ZHAO

Inventor： Yong D. ZHAO ,  Jennifer Jinping ZHAO

IPC: H04R25/00

CPC classification number: H04R25/656 ,  H04R25/658 ,  H04R2225/025

Abstract: An in-ear hearing aid device that provides users with a customizable ear piece to fit the ear canal of any user. More specifically, the present invention can comprises of a hard case to hold all the electronics of the device with a hearing device jacket that envelops the device. An ear mould is connected to the jacket and allows the user to insert the device into the ear canal to enhance the user's hearing.

Abstract translation: 入耳式助听器装置，为用户提供可定制的耳塞，以适应任何用户的耳道。 更具体地说，本发明可以包括一个硬壳，用来容纳该设备的所有电子设备，其中一个听觉装置夹套包围该设备。 耳模连接到护套，并允许使用者将装置插入耳道中以增强使用者的听力。

公开(公告)号：US08108053B2

公开(公告)日：2012-01-31

申请号：US12370461

申请日：2009-02-12

Applicant: Yong D. Zhao

Inventor： Yong D. Zhao

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/086

Abstract: Implantable medical leads have reduced diameter while providing for optimized mechanical and electrical properties, by reducing the diameters of the conducting cables used within the leads for sensing and delivery of therapeutic electrical stimulation. In an embodiment, conducting filaments within a cable have oval cross-sectional areas. Suitably orienting the oval filaments increases the contact surface between adjacent filaments, broadly distributing the pressure between filaments and reducing fretting fatigue, while the oval cross-sectional area also increases conductivity. In an embodiment, non-conducting coatings around filaments within a cable, or around groups of filaments organized into cable-layers, reduce fretting fatigue. In an embodiment, the cross-sectional area of filaments decreases as the filaments are positioned at increasing radial distances from the center of the cable. In an embodiment, the relative composition of various filament metals and/or alloys is varied in filaments at different radial distances from the center of the cable.

Abstract translation: 可植入的医疗引线通过减小引线内使用的导电电缆的直径来获得最佳的机械和电学性能，减小了直径，用于传感和传递治疗性电刺激。 在一个实施例中，电缆内的导电细丝具有椭圆形横截面。 适当地定向椭圆形长丝增加相邻细丝之间的接触表面，广泛地分布长丝之间的压力并减少微动疲劳，而椭圆形横截面积也增加导电性。 在一个实施例中，电缆周围的细丝周围的非导电涂层或组织成电缆层的细丝组周围的非导电涂层减少了微动疲劳。 在一个实施例中，长丝的横截面积随着电缆的距离中心距离增加的径向距离而减小。 在一个实施例中，各种细丝金属和/或合金的相对组成在长丝中在与电缆中心不同的径向距离处变化。

公开(公告)号：US20110079423A1

公开(公告)日：2011-04-07

申请号：US12889189

申请日：2010-09-23

Applicant: Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

Inventor： Yong D. Zhao ,  Rolf Hill ,  Ingmar Viohl ,  Martin Cholette

IPC: H05K9/00 ,  H01F27/30

CPC classification number: A61N1/056 ,  A61N1/086

Abstract: An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.

Abstract translation: 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。

公开(公告)号：US20100036466A1

公开(公告)日：2010-02-11

申请号：US12189555

申请日：2008-08-11

Applicant: Xiaoyi Min ,  Yong D. Zhao ,  Pedro Medrano

Inventor： Xiaoyi Min ,  Yong D. Zhao ,  Pedro Medrano

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/056

Abstract: A lead construction includes a lead body, an electrically conductive element disposed therein, and a shield layer disposed over the conductive element formed from a composite material comprising a polymer material and a non-ferrous particulate material. The non-ferrous material can include gold, platinum, iridium, nickel, cobalt, chromium, molybdenum, carbon/graphite powders, and alloys thereof. The composite material has a non-ferrous particulate content of from about 40 to 90 volume percent, and the shield layer has a thickness of from about 0.1 to 1 mm. The composite material forms an electrically conductive layer when exposed to RF having a frequency of greater than about 64 MHz. A layer of insulating material may be interposed between the shield layer and the conductive element. The shield layer can be part of the lead body, can be an intermediate layer within the lead body, or can be an outer surface of the lead body.

Abstract translation: 引线结构包括引线体，设置在其中的导电元件和设置在由包含聚合物材料和有色金属颗粒材料的复合材料形成的导电元件上的屏蔽层。 有色金属材料可以包括金，铂，铱，镍，钴，铬，钼，碳/石墨粉及其合金。 复合材料具有约40至90体积％的有色金属颗粒含量，并且屏蔽层具有约0.1至1mm的厚度。 当暴露于频率大于约64MHz的RF时，复合材料形成导电层。 可以在屏蔽层和导电元件之间插入一层绝缘材料。 屏蔽层可以是引线体的一部分，可以是引线体内的中间层，也可以是引线体的外表面。

公开(公告)号：US20170071534A1

公开(公告)日：2017-03-16

申请号：US14884365

申请日：2015-10-15

Applicant: Yong D Zhao ,  Jennifer Jinping Zhao

Inventor： Yong D Zhao ,  Jennifer Jinping Zhao

IPC: A61B5/00 ,  A61F11/00 ,  H04R25/00 ,  A61M21/02 ,  A61B5/0476 ,  A61B1/227 ,  A61B5/12 ,  A61B5/16

CPC classification number: A61B5/4836 ,  A61B1/227 ,  A61B5/0004 ,  A61B5/0022 ,  A61B5/0476 ,  A61B5/04845 ,  A61B5/123 ,  A61B5/126 ,  A61B5/128 ,  A61B5/165 ,  A61B5/168 ,  A61B5/4806 ,  A61B5/4884 ,  A61B5/6898 ,  A61B5/7475 ,  A61B2560/0475 ,  A61F11/00 ,  A61M21/02 ,  A61M2021/0027 ,  G06F19/00 ,  G06Q20/145 ,  G07F17/04 ,  G16H40/67 ,  H04R25/554 ,  H04R25/558 ,  H04R25/70 ,  H04R25/75 ,  H04R2225/39 ,  H04R2225/55

Abstract: A practitioner device for facilitating at least one of testing and treatment of at least one auditory disorder is disclosed. The practitioner device includes a user interface configured for receiving an input from a practitioner. Further, the practitioner device includes a communication interface configured for communicating information between the practitioner device and at least one of a mobile device and another practitioner device over at least one of a wired communication channel and a wireless communication channel, wherein the information is based on the input, wherein the information corresponds to at least one of at least one auditory test and at least one auditory treatment procedure, wherein the mobile device facilitates at least one of testing of at least one auditory disorder and treatment of at least one auditory disorder.

Abstract translation: 公开了用于促进至少一种听觉障碍的测试和治疗中的至少一种的从业者装置。 从业者设备包括被配置为接收从业者的输入的用户界面。 此外，从业者设备包括通信接口，其被配置为通过有线通信信道和无线通信信道中的至少一个在从业者设备与移动设备和另一个从业者设备中的至少一个之间传送信息，其中该信息基于 输入，其中所述信息对应于至少一个听觉测试和至少一个听觉治疗程序中的至少一个，其中所述移动设备促进至少一种听觉障碍的测试和至少一种听觉障碍的治疗中的至少一种。

公开(公告)号：US09399129B2

公开(公告)日：2016-07-26

申请号：US12262083

申请日：2008-10-30

Applicant: Yong D. Zhao ,  Xiaoyi Min ,  Virote Indravudh

Inventor： Yong D. Zhao ,  Xiaoyi Min ,  Virote Indravudh

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/08

CPC classification number: A61N1/056 ,  A61N1/086

Abstract: An implantable medical lead is disclosed herein. The lead may include a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and may include a coiled inductor including first and second electrically conductive filar cores. The first and second filar cores may be physically joined into a unified single piece proximal terminal on a proximal end of the coiled inductor. The first and second cores may be physically joined into a unified single piece distal terminal on a distal end of the coiled inductor. The first and second filar cores may be helically wound into a coiled portion between the proximal and distal terminals, the filar cores being electrically isolated from each other in the coiled portion. The proximal terminal may be electrically coupled to a portion of the electrical pathway extending to the lead connector end, and the distal terminal may be electrically coupled to a portion of the electrical pathway extending to the electrode.

Abstract translation: 本文公开了可植入医疗引线。 引线可以包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸并且可以包括包括第一和第二导电丝芯的线圈电感器。 第一和第二丝状芯可以物理地连接到线圈电感器的近端上的统一的单件式近端端子。 第一和第二芯可以物理地连接到线圈电感器的远端上的统一的单件式远端终端。 第一和第二丝芯可以螺旋地缠绕在近端和远端之间的线圈部分中，丝芯在线圈部分中彼此电隔离。 近端端子可以电连接到延伸到引线连接器端的电路径的一部分，并且远端端子可电耦合到延伸到电极的电路径的一部分。