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23 条记录 (耗时 0.022 秒)

    MACROCYCLIC POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF
    11.
    发明申请
    MACROCYCLIC POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF 有权
    大分子聚合物，包含这种聚合物的组合物及其使用和制造方法

    公开(公告)号：US20100081800A1

    公开(公告)日：2010-04-01

    申请号：US12523790

    申请日：2008-01-22

    申请人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    发明人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    IPC分类号： C07H17/08

    CPC分类号： C07H17/08 ,  C07D407/14

    摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

    摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。

    ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MNAUFACTURE AND USE THEREOF
    12.
    发明申请
    ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MNAUFACTURE AND USE THEREOF 有权
    抗生物素化合物及其制备方法及其应用

    公开(公告)号：US20100035833A1

    公开(公告)日：2010-02-11

    申请号：US12324907

    申请日：2008-11-28

    申请人： Yoshi Ichikawa ,  Yu-Hung Chiu ,  Youe-Kong Shue ,  Farah Kondori Babakhani

    发明人： Yoshi Ichikawa ,  Yu-Hung Chiu ,  Youe-Kong Shue ,  Farah Kondori Babakhani

    IPC分类号： A61K31/70

    CPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7048

    摘要： The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).

    摘要翻译： 本发明包括18-元大环抗微生物剂的活性代谢物，具体地，一种泰克霉素B的代谢物，并且在某些实施方案中，R-Tyacumicin B或其相关化合物。 特别地，本发明包括用作治疗细菌感染的有效抗生素的化合物，特别是由艰难梭菌（艰难梭菌）和产气荚膜梭菌（产气荚膜梭菌）的毒素产生菌株引起的GI感染。

    Polymorphic crystalline forms of tiacumicin B
    14.
    发明授权
    Polymorphic crystalline forms of tiacumicin B 有权
    tiacumicin B的多形态结晶形式

    公开(公告)号：US07378508B2

    公开(公告)日：2008-05-27

    申请号：US11831886

    申请日：2007-07-31

    申请人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    发明人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    IPC分类号： C07H17/08 ,  C07D313/00

    CPC分类号： C07H17/08 ,  C07D407/14

    摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

    摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。

    MACROLIDE POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF
    15.
    发明申请
    MACROLIDE POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF 有权
    包含该聚合物的组合物，及其使用和制造方法

    公开(公告)号：US20070259949A1

    公开(公告)日：2007-11-08

    申请号：US11831886

    申请日：2007-07-31

    申请人： Yu-Hung Chiu ,  Tessie Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    发明人： Yu-Hung Chiu ,  Tessie Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    IPC分类号： A61K31/335 ,  A61P31/04 ,  C07D313/00

    CPC分类号： C07H17/08 ,  C07D407/14

    摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

    摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。

    Tea-making utensil
    16.
    发明申请
    Tea-making utensil 审中-公开
    茶具

    公开(公告)号：US20060162572A1

    公开(公告)日：2006-07-27

    申请号：US11038412

    申请日：2005-01-21

    申请人： Su Rong Chiu Liu ,  Yu-Hung Chiu

    发明人： Su Rong Chiu Liu ,  Yu-Hung Chiu

    IPC分类号： A47G19/14

    CPC分类号： A47G19/16 ,  A47J31/02

    摘要： A tea-making utensil comprising a filter cup and a lid shape tea bag, the filter cup has an overhang stretching out from the outer diameter of the open, a concave supporter is on the inner side of the overhang, several water inlet holes are on the inner wall of the filter cup; the lid shape tea bag has a protruding brim to span on top of the concave supporter of the filter cup, the tea bag open is sealed with a sealer. Based on above description and while application, the present invention is easy to carry and effectively isolate green tea from contacting oxygen in the air to preserve the EGCG in the green tea.

    摘要翻译： 一种包括过滤杯和盖形茶袋的制茶器具，所述过滤杯具有从所述开口的外径伸出的伸出部，所述突出部的内侧具有凹状的支撑体，在所述突出部的内侧具有多个吸水孔 过滤杯的内壁; 盖形茶袋具有突出的边缘以跨过过滤杯的凹形支撑件的顶部，茶袋打开用密封剂密封。 基于上述描述和应用，本发明容易携带并有效隔离绿茶与空气中的氧接触，以保留绿茶中的EGCG。

    Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
    17.
    发明授权
    Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof 有权
    大环多晶型物，包含这种多晶型物的组合物，及其使用和制造方法

    公开(公告)号：US08859510B2

    公开(公告)日：2014-10-14

    申请号：US12523790

    申请日：2008-01-22

    申请人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    发明人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    IPC分类号： A61K31/7048 ,  C07D407/14 ,  C07H17/08

    CPC分类号： C07H17/08 ,  C07D407/14

    摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

    摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。

    Antibiotic macrocycle compounds and methods of manufacture and use thereof
    18.
    发明授权
    Antibiotic macrocycle compounds and methods of manufacture and use thereof 有权
    抗生素大环化合物及其制备和使用方法

    公开(公告)号：US08445654B2

    公开(公告)日：2013-05-21

    申请号：US13280148

    申请日：2011-10-24

    申请人： Yoshi Ichikawa ,  Yu-Hung Chiu ,  Youe-Kong Shue ,  Farah Kondori Babakhani

    发明人： Yoshi Ichikawa ,  Yu-Hung Chiu ,  Youe-Kong Shue ,  Farah Kondori Babakhani

    IPC分类号： C07H17/08

    CPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7048

    摘要： The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).

    摘要翻译： 本发明包括18-元大环抗微生物剂的活性代谢物，具体地，一种泰克霉素B的代谢物，并且在某些实施方案中，R-Tyacumicin B或其相关化合物。 特别地，本发明包括用作治疗细菌感染的有效抗生素的化合物，特别是由艰难梭菌（艰难梭菌）和产气荚膜梭菌（产气荚膜梭菌）的毒素产生菌株引起的GI感染。

    MACROLIDE POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF
    20.
    发明申请
    MACROLIDE POLYMORPHS, COMPOSITIONS COMPRISING SUCH POLYMORPHS, AND METHODS OF USE AND MANUFACTURE THEREOF 有权
    包含该聚合物的组合物，及其使用和制造方法

    公开(公告)号：US20080194497A1

    公开(公告)日：2008-08-14

    申请号：US12101552

    申请日：2008-04-11

    申请人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    发明人： Yu-Hung Chiu ,  Tessie Mary Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

    IPC分类号： A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08 ,  C07D407/14

    摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

    摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。