-
公开(公告)号：US20230172983A1
公开(公告)日：2023-06-08
申请号：US17814434
申请日：2022-07-22
IPC分类号： A61K35/17 , C07K14/705 , A61P35/00 , C07K14/725
CPC分类号： A61K35/17 , C07K14/70578 , A61P35/00 , C07K14/70517 , C07K14/70521 , C07K14/7051
摘要： The disclosure provides immune cells comprising a first activator receptor specific to CEA, and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
-
公开(公告)号：US11602544B2
公开(公告)日：2023-03-14
申请号：US17663758
申请日：2022-05-17
发明人： Julyun Oh , Han Xu , Carl Alexander Kamb
摘要： The disclosure provides immune cells comprising a first activator receptor and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
-
公开(公告)号：US20220289818A1
公开(公告)日：2022-09-15
申请号：US17663148
申请日：2022-05-12
IPC分类号： C07K14/705 , A61K35/17 , C07K16/30
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
-
公开(公告)号：US11254726B2
公开(公告)日：2022-02-22
申请号：US17230637
申请日：2021-04-14
IPC分类号： C07K14/705 , A61K35/17 , C07K16/30
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
-
公开(公告)号：US20240075067A1
公开(公告)日：2024-03-07
申请号：US18340435
申请日：2023-06-23
发明人： Yuta ANDO , Julyun OH , Han XU , Carl Alexander Kamb
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2809 , C07K16/2833 , C07K16/2863 , C07K16/30 , A61K2039/507
摘要： The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.
-
公开(公告)号：US20230330227A1
公开(公告)日：2023-10-19
申请号：US18020728
申请日：2021-08-12
IPC分类号： A61K39/00 , C12N5/0783 , C12N15/86 , C07K14/47 , C07K14/72 , A61K31/138 , C07K14/725
CPC分类号： A61K39/4611 , C12N5/0636 , C12N15/86 , C07K14/4747 , C07K14/721 , A61K31/138 , A61K39/4621 , A61K39/4637 , A61K39/46431 , A61K39/4631 , C07K14/7051 , C12N2740/15043 , C07K2319/00 , A61K2239/25
摘要： The disclosure relates to fusion proteins comprising a tBID polypeptide and a steroid hormone receptor domain, and methods of using same to induce apoptosis in cells.
-
公开(公告)号：US20230277593A1
公开(公告)日：2023-09-07
申请号：US18165623
申请日：2023-02-07
发明人： Julyun Oh , Han Xu , Carl Alexander Kamb
CPC分类号： A61K35/17 , A61P35/00 , A61K35/15 , C07K14/705 , C07K16/2833 , C07K16/2863 , C12N5/0693
摘要： The disclosure provides immune cells comprising a first activator receptor and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
-
公开(公告)号：US20230257441A1
公开(公告)日：2023-08-17
申请号：US18020837
申请日：2021-08-12
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61P35/00
CPC分类号： C07K14/7051 , C07K16/2833 , C12N5/0636 , A61P35/00 , C07K2317/24 , C07K2317/622 , C07K2317/565
摘要： The disclosure provides immune cells comprising a first activator receptor and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
-
公开(公告)号：US20220370497A1
公开(公告)日：2022-11-24
申请号：US17662766
申请日：2022-05-10
IPC分类号： A61K35/17 , C07K14/725 , C12N15/113 , A61P35/00
摘要： The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.017 秒)
