公开(公告)号：US11254682B2

公开(公告)日：2022-02-22

申请号：US16933095

申请日：2020-07-20

Applicant: Dana-Farber Cancer Institute, Inc. ,  The Scripps Research Institute

Inventor： Nathanael S. Gray ,  Jianming Zhang ,  Barun Okram ,  Xianming Deng ,  Jae Won Chang ,  Amy Wojciechowski

IPC: C07D473/34 ,  C07D487/04 ,  A61P35/02 ,  A61P35/00 ,  C07D239/94 ,  A61P9/00 ,  A61P19/00 ,  A61P17/00 ,  C07D239/42 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D495/04 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/7076 ,  A61K45/06 ,  C07D471/04 ,  C07H19/16

Abstract: The present disclosure provides novel heteroaryl compounds of formula (IV). Such compounds are useful for the treatment of cancers.

公开(公告)号：US11021453B2

公开(公告)日：2021-06-01

申请号：US16717813

申请日：2019-12-17

Applicant: Lundbeck La Jolla Research Center, Inc. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Micah J. Niphakis ,  Jae Won Chang ,  Kenneth M. Lum ,  Benjamin F. Cravatt

IPC: C07D295/205 ,  A61P25/22 ,  C07C271/12 ,  C07D317/46 ,  C07D317/58 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D471/04 ,  C07D471/10 ,  C07D261/08 ,  C07D487/04 ,  C07D263/32 ,  C07D205/04 ,  C07D491/107 ,  C07D207/14 ,  C07D271/06 ,  C07D307/79 ,  C07D405/14 ,  C07D215/42 ,  C07D213/40 ,  C07D295/26 ,  C07D213/55 ,  C07D401/04 ,  C07D407/06 ,  C07D413/06 ,  C07C271/10 ,  C07D207/09 ,  C07D213/38 ,  C07D215/46 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.

公开(公告)号：US20150080364A1

公开(公告)日：2015-03-19

申请号：US14383076

申请日：2013-03-15

Applicant: Abide Therapeutics, Inc. ,  The Scripps Research Insititute

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Dong-Hui Wang ,  Olivia Weber ,  Benjamin F. Cravatt ,  Micah J. Niphakis ,  Armand Cognetta ,  Jae Won Chang

IPC: C07D207/46 ,  C07D401/12 ,  C07D487/04 ,  C07D491/107 ,  C07D471/04 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D207/46 ,  C07D209/48 ,  C07D233/80 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.

Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。