公开(公告)号：US20230168249A1

公开(公告)日：2023-06-01

申请号：US17922590

申请日：2021-05-04

Applicant: Academia Sinica

Inventor： An-Suei YANG ,  Chao-Ping TUNG ,  Chung-Ming YU ,  Chi-Yung CHEN ,  Yu-Chuan HUANG ,  Pei-Hsun TSAI ,  Szu-Yu LIN ,  Hung-Ju HSU ,  Hung-Pin PENG ,  Fei-Hung HUNG

IPC: G01N33/569 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K16/10 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2470/04 ,  G01N2469/10

Abstract: Disclosed herein are recombinant antibodies or the fragment thereof for detecting severe acute respiratory syndrome coronavirus (SARS-CoV). According to some embodiments, the SARS-CoV is SARS-CoV-1. According to some alternative embodiments, the SARS-CoV is SARS-CoV-2. Also disclosed herein are a kit comprising the recombinant antibodies, and a method for diagnosing the infection of SARS-CoV by using the recombinant antibody or the kit.

公开(公告)号：US20210292413A1

公开(公告)日：2021-09-23

申请号：US17266092

申请日：2018-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang HSIEH ,  Tsung-Yu TSAI ,  An-Suei YANG ,  Chung-Ming YU ,  Cheng-Yuan PENG

IPC: C07K16/28 ,  A61P31/20

Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.

公开(公告)号：US20190040151A1

公开(公告)日：2019-02-07

申请号：US16166220

申请日：2018-10-22

Applicant: Academia Sinica

Inventor： An-Suei YANG ,  Wei-Ying KUO ,  Hung-Ju HSU ,  Hong-Sen CHEN ,  Yu-Chi CHOU ,  Yueh-Liang TSOU ,  Hung-Pin PENG ,  Jhih-Wei JIAN ,  Chung-Ming YU ,  Yi-Kai CHIU ,  Ing-Chein CHEN ,  Chao-Ping TUNG ,  Michael HSIAO ,  Hwei-Jiung WANG

IPC: C07K16/30 ,  A61K47/68 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K47/6829 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

公开(公告)号：US20170355750A1

公开(公告)日：2017-12-14

申请号：US15619835

申请日：2017-06-12

Applicant: Academia Sinica

Inventor： An-Suei YANG ,  Hong-Sen CHEN ,  Chung-Ming YU ,  Shin-Chen HOU ,  Wei-Ying KUO ,  Yi-Kai CHIU ,  Yueh-Liang TSOU ,  Hung-Ju HSU ,  Hwei-Jiung WANG ,  Shih-Hsien CHUANG ,  Chao-Pin LEE

IPC: C07K16/00 ,  C07K16/32 ,  C07K19/00 ,  A61K39/00

Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.