公开(公告)号：US20240277865A1

公开(公告)日：2024-08-22

申请号：US18567765

申请日：2022-06-08

申请人： Academia Sinica

发明人： An-Suei YANG ,  Hung-Ju HSU ,  Chao-Ping TUNG ,  Chung-Ming YU ,  Chi-Yung CHEN ,  Hong-Sen CHEN ,  Yu-Chuan HUANG ,  Pei-Hsun TSAI ,  Szu-Yu LIN ,  Hung-Pin PENG

IPC分类号： A61K47/68 ,  A61K39/00 ,  A61P35/00 ,  C07K16/00 ,  C07K16/30

CPC分类号： A61K47/6851 ,  A61K47/68031 ,  A61K47/6829 ,  A61P35/00 ,  C07K16/005 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73

摘要： Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized with a specific sequence in each CDR. The present phage-displayed scFv library is useful in selecting an antibody fragment exhibiting a binding affinity and specificity to mesothelin (MSLN). Also disclosed herein are a recombinant antibody specific to MSLN, an immunoconjugate comprising the recombinant antibody, and uses thereof in treating cancers.

公开(公告)号：US20230168249A1

公开(公告)日：2023-06-01

申请号：US17922590

申请日：2021-05-04

申请人： Academia Sinica

发明人： An-Suei YANG ,  Chao-Ping TUNG ,  Chung-Ming YU ,  Chi-Yung CHEN ,  Yu-Chuan HUANG ,  Pei-Hsun TSAI ,  Szu-Yu LIN ,  Hung-Ju HSU ,  Hung-Pin PENG ,  Fei-Hung HUNG

IPC分类号： G01N33/569 ,  C07K16/10

CPC分类号： G01N33/56983 ,  C07K16/10 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2470/04 ,  G01N2469/10

摘要： Disclosed herein are recombinant antibodies or the fragment thereof for detecting severe acute respiratory syndrome coronavirus (SARS-CoV). According to some embodiments, the SARS-CoV is SARS-CoV-1. According to some alternative embodiments, the SARS-CoV is SARS-CoV-2. Also disclosed herein are a kit comprising the recombinant antibodies, and a method for diagnosing the infection of SARS-CoV by using the recombinant antibody or the kit.