公开(公告)号：US11275259B2

公开(公告)日：2022-03-15

申请号：US17304691

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Nabin Joshi ,  Arkady Selenow ,  Steven Ali ,  Stefan Bauer ,  Jean-Noël Fehr ,  Moritz Haeberli ,  Patrizia Weber ,  Julien Sauvet ,  Amitava Gupta

IPC: G02C7/02 ,  G02C7/04 ,  G02C7/06 ,  A61B3/00 ,  A61F9/00 ,  G02C11/04

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US11209672B1

公开(公告)日：2021-12-28

申请号：US17301537

申请日：2021-04-06

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Gordon Frederick MacCabee ,  Ferry Widjaja ,  Amitava Gupta

IPC: G02C11/00 ,  G02C7/04 ,  A61N5/06

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US12226647B2

公开(公告)日：2025-02-18

申请号：US17052906

申请日：2019-05-03

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: A61N5/06 ,  A61N5/067 ,  G02C7/04

Abstract: A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

公开(公告)号：US12147092B2

公开(公告)日：2024-11-19

申请号：US18051804

申请日：2022-11-01

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Gordon Frederick Maccabee ,  Ferry Widjaja ,  Amitava Gupta

IPC: G02C11/00 ,  G02C7/04 ,  A61N5/06

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US12105362B2

公开(公告)日：2024-10-01

申请号：US18330010

申请日：2023-06-06

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Amitava Gupta ,  Stefan Bauer ,  Benjamin Crook ,  Julien Sauvet

IPC: G02C7/08 ,  G02C7/02 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14

CPC classification number: G02C7/08 ,  G02C7/022 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US11986669B2

公开(公告)日：2024-05-21

申请号：US18153000

申请日：2023-01-11

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noel Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11733545B2

公开(公告)日：2023-08-22

申请号：US17753773

申请日：2020-09-15

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Jean-Noël Fehr ,  Hans Bernhard ,  Patrizia Weber ,  Alain Saurer ,  Amitava Gupta

IPC: G02C7/04 ,  G02C11/00 ,  G02C11/04

CPC classification number: G02C7/047 ,  G02C11/04 ,  G02C11/10 ,  G02C2202/24

Abstract: An opto-electronic module is configured to fit between anterior and posterior surfaces of a contact lens. The opto-electronics module may comprise a plurality of light sources configured to direct a plurality of light beams to a region of the retina away from the fovea and in some embodiments away from the macula. Each of the plurality of light sources may comprises an LED and one or more projection optics. Each of the projection optics can be coupled to an LED with an adhesive prior to placing the opto-electronics module on a layer of contact lens material. The opto-electronics module may comprise a flex PCB with the plurality of light sources, an antenna, a battery, a capacitor and a processor supported on the flex PCB.

公开(公告)号：US11624937B2

公开(公告)日：2023-04-11

申请号：US17250278

申请日：2019-07-03

Applicant: ACUCELA INC.

Inventor： Amitava Gupta ,  Ryo Kubota

IPC: G02C7/02 ,  G02C7/04 ,  G02C11/04 ,  G02C11/00

Abstract: A contact lens configured to decrease dark adaptation comprises one or more LEDs and directs light from the LED away from the fovea and toward the parafovea or perifoveal regions of the retain. In some embodiments, soft contact lens embedded with one or more arrays of microLEDs and electronics operating the LEDs is configured to be worn at night in order to inhibit dark adaptation and reduce oxygen consumption by the rods. The contact lens may be made of a single layer of a contact lens material or multiple layers sandwiching a flexible transparent plastic layer comprising the electronics and the LED arrays. The contact lens may be made of a hydrophilic hydrogel material that is biocompatible to the human cornea, or a silicone hydrogel material. The contact lens may be spherical and may provide refractive correction to the eye of the wearer.

公开(公告)号：US11583696B2

公开(公告)日：2023-02-21

申请号：US17662098

申请日：2022-05-05

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noël Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11358001B2

公开(公告)日：2022-06-14

申请号：US16947537

申请日：2020-08-05

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noël Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.