公开(公告)号：US11136390B2

公开(公告)日：2021-10-05

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee ,  William Monteith ,  Herve Rhinn ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190040131A1

公开(公告)日：2019-02-07

申请号：US16054840

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12247073B2

公开(公告)日：2025-03-11

申请号：US17272083

申请日：2019-08-30

Applicant: Alector LLC

Inventor： Patricia Culp ,  Helen Lam ,  Wei-Hsien Ho ,  Leonard G. Presta ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a CD33 polypeptide, e.g., a mammalian CD33 or human CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230121869A1

公开(公告)日：2023-04-20

申请号：US17931757

申请日：2022-09-13

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11084875B2

公开(公告)日：2021-08-10

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US10711062B2

公开(公告)日：2020-07-14

申请号：US16054840

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  C07K16/46 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.