公开(公告)号：US12110327B2

公开(公告)日：2024-10-08

申请号：US17931757

申请日：2022-09-13

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240067723A1

公开(公告)日：2024-02-29

申请号：US18298110

申请日：2023-04-10

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11634489B2

公开(公告)日：2023-04-25

申请号：US16835140

申请日：2020-03-30

Applicant: Alector LLC

Inventor： Tina Schwabe ,  Eric Brown ,  Philip Kong ,  Ilaria Tassi ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Robert Pejchal ,  Nels P. Nielson

IPC: A61P25/28 ,  A61K39/00 ,  C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11147249B2

公开(公告)日：2021-10-19

申请号：US15836089

申请日：2017-12-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Seung-Joo Lee

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/705

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US10800844B2

公开(公告)日：2020-10-13

申请号：US15772010

申请日：2016-10-28

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  A61P31/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12226482B2

公开(公告)日：2025-02-18

申请号：US18454286

申请日：2023-08-23

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.

公开(公告)号：US11897968B2

公开(公告)日：2024-02-13

申请号：US17118921

申请日：2020-12-11

Applicant: Alector LLC

Inventor： Seung-Joo Lee ,  Spencer Liang ,  Angie Yee ,  Marina Roell ,  Arnon Rosenthal

IPC: C07K16/40 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20230121869A1

公开(公告)日：2023-04-20

申请号：US17931757

申请日：2022-09-13

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10711062B2

公开(公告)日：2020-07-14

申请号：US16054840

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  C07K16/46 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190174730A1

公开(公告)日：2019-06-13

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.