公开(公告)号：US11084875B2

公开(公告)日：2021-08-10

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US20240067723A1

公开(公告)日：2024-02-29

申请号：US18298110

申请日：2023-04-10

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10800844B2

公开(公告)日：2020-10-13

申请号：US15772010

申请日：2016-10-28

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  A61P31/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11174313B2

公开(公告)日：2021-11-16

申请号：US15735946

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Francesca Avogadri-Connors

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/62 ,  C12N15/85 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11136390B2

公开(公告)日：2021-10-05

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee ,  William Monteith ,  Herve Rhinn ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11667710B2

公开(公告)日：2023-06-06

申请号：US17016744

申请日：2020-09-10

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  G01N33/577 ,  G01N33/574 ,  A61P31/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574 ,  G01N33/577

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10590198B2

公开(公告)日：2020-03-17

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Francesca Avogadri-Connors ,  William Monteith

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00 ,  A61P37/02 ,  A61P25/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190315858A1

公开(公告)日：2019-10-17

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US11965023B2

公开(公告)日：2024-04-23

申请号：US17740100

申请日：2022-05-09

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07K16/2803 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11359014B2

公开(公告)日：2022-06-14

申请号：US16614302

申请日：2018-05-15

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61P37/00 ,  A61P25/28 ,  A61P31/04 ,  A61P25/00 ,  A61P25/08 ,  A61P29/00 ,  A61P35/00 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.