公开(公告)号：US3663552A

公开(公告)日：1972-05-16

申请号：US3663552D

申请日：1970-04-09

Applicant: AMERICAN HOME PROD

Inventor： YARDLEY JOHN P ,  BRIGHT ROYAL E ,  REES RICHARD W ,  SMITH HERCHEL

IPC: C07D453/04 ,  C07D43/24

CPC classification number: C07D453/04 ,  Y10S514/821 ,  Y10S514/895

Abstract: 2''-SUBSTITUTED ALKALOIDS OF THE CINCHONA SERIES, ESPECIALLY 2''-SUBSTITUTED QUININE, QUINIDINE, CINCHONIE, CINCHONIDINE AND DIHYDRO ANALOGS OF FORMULAS I AND II, AND THEIR SALTS, ARE PREPARED BY TREATING AR-N-OXIDES OF THE ALKALOIDS WITH THE CORRESPONDING ORGANOMETALLIC REAGENT AND, IF DESIRED, CONVERTING THE FREE BASES THUS FORMED INTO PHARMACEUTICALLY-ACCEPTABLE ACID-ADDITION SALTS. THE NEW COMPOUNDS ARE PHARMACOLOGICALLY ACTIVE, ESPECIALLY ANTIMALARIALLY AND ANTI-ARRHYTHMICALLY.

公开(公告)号：US3574196A

公开(公告)日：1971-04-06

申请号：US3574196D

申请日：1967-03-13

Applicant: AMERICAN HOME PROD

Inventor： FOELL THEODORE J ,  REES RICHARD W ,  SMITH HERCHEL

IPC: A61K31/568 ,  A61K31/5685 ,  A61K31/569 ,  A61K31/57 ,  A61K31/573 ,  C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J75/00 ,  C07C169/14 ,  C07C169/26

CPC classification number: A61K31/573 ,  A61K31/568 ,  A61K31/5685 ,  A61K31/569 ,  A61K31/57 ,  C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J75/00

Abstract: STEROIDS WITH $-1,4 A RINGS UNSUBSTITUTED IN THE 3-POSITION (I) AND HAVING ADRENOCORTICAL, PROGESTATIONAL, ANDROGENIC AND ANABOLIC ACTIVITY ARE PROVIDED BY REDUCING STEROIDAL $1,4-3-OLS (II) OR-ACYLATES (III). COMPOUNDS (II) ARE PROVIDED BY REDUCING STEROIDAL $1,4-3-ONES (IV) WITH ALUMINUM HYDRIDE IN THE COLD. COMPOUNDS (I) ALSO ARE PROVIDED BY REDUCING COMPOUNDS (IV) WITH WARM ALUMINUM HYDRIDE AND SEPARATING THEM FROM 1,3- AND 2,4DIENE BYPRODUCTS BY SELECTIVE REDUCTION OF THE BYPRODUCTS WITH LITHIUM IN AMMONIA.

公开(公告)号：US3509157A

公开(公告)日：1970-04-28

申请号：US3509157D

申请日：1966-10-31

Applicant: AMERICAN HOME PROD

Inventor： REES RICHARD W ,  SMITH HERCHEL

IPC: C07D471/22 ,  C07D43/34

CPC classification number: C07D471/22

公开(公告)号：US3509155A

公开(公告)日：1970-04-28

申请号：US3509155D

申请日：1966-10-31

Applicant: AMERICAN HOME PROD

Inventor： REES RICHARD W ,  SMITH HERCHEL

IPC: C07D471/20 ,  C07D43/34

CPC classification number: C07D471/20

公开(公告)号：US3455909A

公开(公告)日：1969-07-15

申请号：US3455909D

申请日：1968-05-29

Applicant: AMERICAN HOME PROD

Inventor： FOELL THEODORE J ,  REES RICHARD W ,  SMITH HERCHEL

IPC: C07J21/00 ,  C07J75/00 ,  C07C173/00 ,  C07C169/20

CPC classification number: C07J21/00 ,  C07J75/00