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公开(公告)号：US20220249778A1
公开(公告)日：2022-08-11
申请号：US17627008
申请日：2020-07-16
Applicant: AMGEN INC.
Inventor： Mehran Mojarrad , Ali Nekouzadeh , Sheldon B. Moberg , Scott R. Gibson , Paul Daniel Faucher
Abstract: A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.
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公开(公告)号：US11129936B2
公开(公告)日：2021-09-28
申请号：US16089685
申请日：2017-04-07
Applicant: AMGEN INC.
Inventor： Scott R. Gibson , Sheldon B. Moberg , Basel Hasan Taha , Margaux Frances Boyaval , Mark A. Destefano , Lawton Laurence , John C. Love , Ian B. Hanson , Paul F. Bente, IV , Matthew J. Clemente , Antonio Ubach , Rajan Ramaswamy , Daniel S. Codd , Scott Beaver , Kevin L. Bokelman , Ian P. Dardani , Sean M. O'connor , Danielle Feldman
Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.
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公开(公告)号：US20190275241A1
公开(公告)日：2019-09-12
申请号：US16297408
申请日：2019-03-08
Applicant: AMGEN INC.
Inventor： Lawrence S. Ring , Tohid Pirbodaghi , Samin Akbari , Daniel Eduardo Groszmann , Mehran Mojarrad , Mark Gordon , Mikhail Tikh , Jimmie L. Ward , Scott R. Gibson , Sheldon B. Moberg , Joshua Tamsky , Paul Faucher
Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.
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公开(公告)号：US12070582B2
公开(公告)日：2024-08-27
申请号：US17094176
申请日：2020-11-10
Applicant: AMGEN INC.
Inventor： Mehran Mojarrad , Ali Nekouzadeh , Susan McConnell Montalvo , Scott R. Gibson , Sheldon B. Moberg , Joshua Tamsky , Paul D. Faucher
IPC: A61M5/315
CPC classification number: A61M5/31513 , A61M2005/3152
Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.
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公开(公告)号：US11464706B2
公开(公告)日：2022-10-11
申请号：US17435421
申请日：2020-04-01
Applicant: AMGEN INC.
Inventor： Sheldon B. Moberg
IPC: A61J1/16
Abstract: A drug delivery system includes a drug delivery device that delivers medicament to a user and a storage container having a container body that defines at least one storage compartment. The storage container includes a controller, at least one temperature sensor associated with the at least one storage compartment, at least one temperature control device associated with the at least one storage compartment, and at least one retention mechanism coupled to the storage container. In response to a user input, the controller is adapted to activate the at least one temperature control device to adjust the temperature in the at least one storage compartment to an administration temperature and transmit a signal to the at least one retention mechanism to release the drug delivery device from the at least one storage compartment after the temperature in the at least one storage compartment reaches the administration temperature.
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Patent Agency Ranking
公开(公告)号：US20220096326A1
公开(公告)日：2022-03-31
申请号：US17435421
申请日：2020-04-01
Applicant: AMGEN INC.
Inventor： Sheldon B. Moberg
IPC: A61J1/16
Abstract: A drug delivery system includes a drug delivery device that delivers medicament to a user and a storage container having a container body that defines at least one storage compartment. The storage container includes a controller, at least one temperature sensor associated with the at least one storage compartment, at least one temperature control device associated with the at least one storage compartment, and at least one retention mechanism coupled to the storage container. In response to a user input, the controller is adapted to activate the at least one temperature control device to adjust the temperature in the at least one storage compartment to an administration temperature and transmit a signal to the at least one retention mechanism to release the drug delivery device from the at least one storage compartment after the temperature in the at least one storage compartment reaches the administration temperature.
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公开(公告)号：US20240100247A1
公开(公告)日：2024-03-28
申请号：US17767466
申请日：2020-10-01
Applicant: AMGEN INC.
Inventor： Tohid Pirbodaghi , Joshua Tamsky , Paul Daniel Faucher , Jeff Lind , Scott R. Gibson , Sheldon B. Moberg , Samin Akbari
CPC classification number: A61M5/14248 , A61M5/1454 , A61M5/16881 , A61M39/26 , A61M2005/14252
Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, and a fluid flow path. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container and a valve assembly. The fluid flow connection is coupled with the container and the needle insertion mechanism and is adapted to allow the medicament to flow from the container to the needle insertion mechanism. The valve assembly is repeatedly movable between at least a valve open position and a valve closed position to selectively allow and restrict the medicament to flow through the needle and/or the cannula.
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公开(公告)号：US20220355025A1
公开(公告)日：2022-11-10
申请号：US17641458
申请日：2020-10-05
Applicant: AMGEN INC.
Inventor： Tohid Pirbodaghi , Samin Akbari , Joshua Tamsky , Paul Daniel Faucher , Scott Robert Gibson , Sheldon B. Moberg
Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, and a needle insertion mechanism (NIM). The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism (NIM) is operably coupled with the activation mechanism and includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container. The actuation assembly is movable between a storage state, a first operational state, a second operational state, and a third operational state to selectively position the needle and the cannula.
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公开(公告)号：US20210402083A1
公开(公告)日：2021-12-30
申请号：US17386659
申请日：2021-07-28
Applicant: AMGEN INC.
Inventor： Scott R. Gibson , Sheldon B. Moberg , Basel Hasan Taha , Margaux Frances Boyaval , Mark A. Destefano , Lawton Laurence , John C. Love , Ian B. Hanson , Paul F. Bente, IV , Matthew J. Clemente , Antonio Ubach , Rajan Ramaswamy , Daniel S. Codd , Scott Beaver , Kevin L. Bokelman , Ian P. Dardani , Sean M. O'connor , Danielle Feldman
Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.
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公开(公告)号：US20210146055A1
公开(公告)日：2021-05-20
申请号：US17094176
申请日：2020-11-10
Applicant: AMGEN INC.
Inventor： Mehran Mojarrad , Ali Nekouzadeh , Susan McConnell Montalvo , Scott R. Gibson , Sheldon B. Moberg , Joshua Tamsky , Paul D. Faucher
IPC: A61M5/315
Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.
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