公开(公告)号：US20160102140A1

公开(公告)日：2016-04-14

申请号：US14894285

申请日：2014-05-30

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS

IPC: C07K16/18 ,  C12N7/00

CPC classification number: C07K16/18 ,  A61K38/16 ,  A61K2039/505 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2319/10 ,  C12N7/00 ,  C12N2740/15043 ,  C12N2740/15071

Abstract: The present invention provides methods of delivering a protein to the brain of a mammal, comprising administering to the mammal a therapeutic fusion protein comprising a homeodomain peptide operably linked to a therapeutic agent.

Abstract translation: 本发明提供了将蛋白质递送至哺乳动物的脑中的方法，包括向哺乳动物施用包含与治疗剂可操作连接的同源域名肽的治疗性融合蛋白。

公开(公告)号：US20250084157A1

公开(公告)日：2025-03-13

申请号：US18829906

申请日：2024-09-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  A61K39/00 ,  C07K16/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20210373036A1

公开(公告)日：2021-12-02

申请号：US17242780

申请日：2021-04-28

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Stephanie WILLIAMS ,  Lalitha VENKATARAMAN

IPC: G01N33/68 ,  C07K16/18

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.

公开(公告)号：US20210324060A1

公开(公告)日：2021-10-21

申请号：US17327462

申请日：2021-05-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  C07K16/00 ,  G01N33/68 ,  C12N15/10

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20210032634A1

公开(公告)日：2021-02-04

申请号：US16712652

申请日：2019-12-12

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Lalitha VENKATARAMAN ,  Wei XIN

IPC: C12N15/62 ,  C07K16/18 ,  A61P25/28 ,  C07K1/22 ,  G01N33/68

Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.

公开(公告)号：US20180298086A1

公开(公告)日：2018-10-18

申请号：US15881392

申请日：2018-01-26

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  G01N33/68 ,  C12N15/10

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20160320412A1

公开(公告)日：2016-11-03

申请号：US15107815

申请日：2014-11-24

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Stephanie WILLIAMS

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/005 ,  G01N2333/4709 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/50

Abstract: The invention provides diagnostic tests to distinguish between different pre-symptomatic neurodegenerative diseases.

Abstract translation: 本发明提供诊断测试以区分不同的症状前症状的神经变性疾病。