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公开(公告)号：US20080227195A1
公开(公告)日：2008-09-18
申请号：US11978121
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08357532B2
公开(公告)日：2013-01-22
申请号：US13443800
申请日：2012-04-10
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US08114628B2
公开(公告)日：2012-02-14
申请号：US11978121
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US20110217733A1
公开(公告)日：2011-09-08
申请号：US11978223
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08945926B2
公开(公告)日：2015-02-03
申请号：US13329202
申请日：2011-12-16
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US20120253026A1
公开(公告)日：2012-10-04
申请号：US13329202
申请日：2011-12-16
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US07608423B2
公开(公告)日：2009-10-27
申请号：US11710672
申请日：2007-02-22
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08173393B2
公开(公告)日：2012-05-08
申请号：US11978223
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US07794978B2
公开(公告)日：2010-09-14
申请号：US11978172
申请日：2007-10-26
IPC分类号： C12P21/00
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US20100160618A1
公开(公告)日：2010-06-24
申请号：US12583558
申请日：2009-08-20
IPC分类号： C07H21/00
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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