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11.发明授权Multiblock biodegradable hydrogels for drug delivery and tissue treatment 失效用于药物递送和组织治疗的多嵌段可生物降解水凝胶公开(公告)号：US06201065B1
公开(公告)日：2001-03-13
申请号：US08692914
申请日：1996-07-26
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08L5300
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。
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公开(公告)号：US07008635B1
公开(公告)日：2006-03-07
申请号：US09658390
申请日：2000-09-08
申请人： Arthur J. Coury , Stephen D. Goodrich , Hildegard M. Kramer , Luis Z. Avila , John F. Traverse , Peter K. Jarrett
发明人： Arthur J. Coury , Stephen D. Goodrich , Hildegard M. Kramer , Luis Z. Avila , John F. Traverse , Peter K. Jarrett
CPC分类号： A61K9/06
摘要： Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.
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公开(公告)号：US06261544B1
公开(公告)日：2001-07-17
申请号：US09249841
申请日：1999-02-15
IPC分类号： A61K31765
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q5/006 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US5618850A
公开(公告)日：1997-04-08
申请号：US401931
申请日：1995-03-09
IPC分类号： A61K9/00 , A61K8/365 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/85 , A61K8/86 , A61K8/90 , A61K31/07 , A61K31/355 , A61K31/59 , A61K31/765 , A61K31/78 , A61K31/79 , A61K45/00 , A61K47/48 , A61P1/00 , A61P3/02 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P33/10 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K31/77
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US5879688A
公开(公告)日：1999-03-09
申请号：US739644
申请日：1996-10-30
IPC分类号： A61K9/00 , A61K8/365 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/85 , A61K8/86 , A61K8/90 , A61K31/07 , A61K31/355 , A61K31/59 , A61K31/765 , A61K31/78 , A61K31/79 , A61K45/00 , A61K47/48 , A61P1/00 , A61P3/02 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P33/10 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/40
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US5662712A
公开(公告)日：1997-09-02
申请号：US483194
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US06176871B1
公开(公告)日：2001-01-23
申请号：US09172537
申请日：1998-10-14
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61B2017/22001 , A61F2/945 , A61F2/95 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , A61L31/14 , B29C35/08 , B29C49/00 , B29C49/0042 , B29C55/24 , B29C70/74 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US5741323A
公开(公告)日：1998-04-21
申请号：US477370
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US6162241A
公开(公告)日：2000-12-19
申请号：US129735
申请日：1998-08-05
IPC分类号： A61L27/00 , A61K9/16 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , C08G63/676 , C08G65/00 , C08G85/00 , A61B17/08
CPC分类号： C08G63/676 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61L2300/418 , A61L2400/04 , C08G63/64 , C08L67/04
摘要： A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can control bleeding at the site and may also provide improved adherence of the sealant to tissue and provide shorter healing times.
摘要翻译： 一种通过在组织密封剂组合物中应用止血剂来控制止血的方法。 组织密封剂是可生物降解的生物相容性合成聚合物，其本身不具有强的止血性能。 将止血材料包括在组织密封剂中可以控制该部位的渗血并且还可以提供密封剂对组织的改善的粘附并提供更短的愈合时间。
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