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公开(公告)号：US06923986B2
公开(公告)日：2005-08-02
申请号：US10650163
申请日：2003-08-27
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08G65/32 , A61K9/00 , A61K9/107 , A61K9/127 , A61K9/14 , A61K9/20 , A61K9/51 , A61K9/70 , A61K38/17 , A61K47/32 , A61K47/34 , A61K48/00 , A61L15/58 , A61L15/60 , A61L24/00 , A61L24/04 , C08F299/02 , C08G18/40 , C08G63/00 , C08G63/672 , C08G65/329 , C08L71/02 , A61K31/765 , C08L53/00
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US06410645B1
公开(公告)日：2002-06-25
申请号：US09710416
申请日：2000-11-09
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： A61K31765
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US06261544B1
公开(公告)日：2001-07-17
申请号：US09249841
申请日：1999-02-15
IPC分类号： A61K31765
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q5/006 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US5618850A
公开(公告)日：1997-04-08
申请号：US401931
申请日：1995-03-09
IPC分类号： A61K9/00 , A61K8/365 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/85 , A61K8/86 , A61K8/90 , A61K31/07 , A61K31/355 , A61K31/59 , A61K31/765 , A61K31/78 , A61K31/79 , A61K45/00 , A61K47/48 , A61P1/00 , A61P3/02 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P33/10 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K31/77
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US06639014B2
公开(公告)日：2003-10-28
申请号：US10114722
申请日：2002-04-02
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08L5300
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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6.发明授权Multiblock biodegradable hydrogels for drug delivery and tissue treatment 失效用于药物递送和组织治疗的多嵌段可生物降解水凝胶公开(公告)号：US06201065B1
公开(公告)日：2001-03-13
申请号：US08692914
申请日：1996-07-26
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08L5300
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。
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7.发明授权Multiblock biodegradable hydrogels for drug delivery and tissue treatment 有权用于药物递送和组织治疗的多嵌段可生物降解水凝胶公开(公告)号：US07250177B2
公开(公告)日：2007-07-31
申请号：US11158565
申请日：2005-06-22
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。
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公开(公告)号：US5879688A
公开(公告)日：1999-03-09
申请号：US739644
申请日：1996-10-30
IPC分类号： A61K9/00 , A61K8/365 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/85 , A61K8/86 , A61K8/90 , A61K31/07 , A61K31/355 , A61K31/59 , A61K31/765 , A61K31/78 , A61K31/79 , A61K45/00 , A61K47/48 , A61P1/00 , A61P3/02 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P33/10 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/40
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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9.发明授权Redox and photoinitiator systems for priming and improved adherence of gels to substrates 失效氧化还原和光引发剂体系，用于引发和改善凝胶对底物的粘附
公开(公告)号：US6121341A
公开(公告)日：2000-09-19
申请号：US973077
申请日：1997-10-10
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08K1/00 , A61F2/00
CPC分类号： C09D4/00 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/904
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。 出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。
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10.发明授权Redox and photoinitiator systems for priming for improved adherence of gels to substrates 有权氧化还原和光引发剂体系，用于引发凝胶以增强凝胶对底物的粘附性公开(公告)号：US06387977B1
公开(公告)日：2002-05-14
申请号：US09616256
申请日：2000-07-14
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： C09D400
CPC分类号： C09D4/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L2300/00 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C08L2666/02 , C09J151/00 , Y10S602/904 , C08L71/02 , C08L33/04 , C08F220/00
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： 公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。
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