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公开(公告)号：US08772480B2
公开(公告)日：2014-07-08
申请号：US13681230
申请日：2012-11-19
Applicant: Amgen Inc.
Inventor： Kristin L. Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L. M. Jackson , Brian Alan Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian Leonard Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin C. Yang
IPC: C07D401/04 , C07D401/14 , A61K31/444 , A61K31/53 , A61P35/00
CPC classification number: C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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公开(公告)号：US12083121B2
公开(公告)日：2024-09-10
申请号：US17579359
申请日：2022-01-19
Applicant: AMGEN INC.
Inventor： John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
IPC: C07D241/04 , A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
CPC classification number: A61K31/519 , A61K31/551 , A61K39/39558 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.-
公开(公告)号：US11993597B2
公开(公告)日：2024-05-28
申请号：US17692026
申请日：2022-03-10
Applicant: Amgen Inc.
Inventor： Brian Alan Lanman , Shon Booker , Clifford Goodman , Anthony B. Reed , Jonathan D. Low , Hui-Ling Wang , Ning Chen , Ana Elena Minatti , Ryan Wurz , Victor J. Cee
IPC: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07
CPC classification number: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07 , A61K2300/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11766436B2
公开(公告)日：2023-09-26
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC classification number: A61K31/517 , A61K31/4985 , A61K39/39558 , A61P35/00 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11306087B2
公开(公告)日：2022-04-19
申请号：US16817109
申请日：2020-03-12
Applicant: Amgen Inc.
Inventor： Brian Alan Lanman , Shon Booker , Clifford Goodman , Anthony B. Reed , Jonathan D. Low , Hui-Ling Wang , Ning Chen , Ana Elena Minatti , Ryan Wurz , Victor J. Cee
IPC: C07D471/04 , A61P35/00 , A61K31/519 , A61K31/7068 , A61K38/07
Abstract: Provided herein are methods of using KRAS G12C inhibitors. These methods of using the inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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Patent Agency Ranking
公开(公告)号：US11285156B2
公开(公告)日：2022-03-29
申请号：US16438349
申请日：2019-06-11
Applicant: Amgen Inc.
Inventor： John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
IPC: A61K31/497 , C07D241/04 , A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US10532042B2
公开(公告)日：2020-01-14
申请号：US15849905
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： Brian Alan Lanman , Victor J. Cee , Alexander J. Pickrell , Anthony B. Reed , Kevin C. Yang , David John Kopecky , Hui-Ling Wang , Patricia Lopez , Kate Ashton , Shon Booker , Christopher M. Tegley
IPC: C07D487/04 , A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D401/04 , C07D403/04 , C07D239/80 , C07D417/04 , C07D471/04 , C07D471/08 , C07D487/10 , C07D275/04 , C07D513/04
Abstract: Provided herein are KRAS G12C inhibitors, compounds of formula (II), or a pharmaceutically acceptable salt thereof: compositions of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US09242961B2
公开(公告)日：2016-01-26
申请号：US14045715
申请日：2013-10-03
Applicant: Amgen Inc.
Inventor： Victor J. Cee , Karina Romero
IPC: C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , C07D471/04 , C07D497/04 , C07D491/048 , C07D495/04
CPC classification number: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
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公开(公告)号：US20150266824A1
公开(公告)日：2015-09-24
申请号：US14633936
申请日：2015-02-27
Applicant: AMGEN INC. , Teijin Pharma Limited
Inventor： Hilary Plake Beck , Shon Keith Booker , Howard Bregman , Victor J. Cee , Nagasree Chakka , Timothy D. Cushing , Oleg Epstein , Brian M. Fox , Stephanie Geuns-Meyer , Xiaolin Hao , Kenta Hibiya , Jun Kirata , Zihao Hua , Jason Human , Shinji Kakuda , Patricia Lopez , Ryota Nakajima , Kazuhisa Okada , Steven H. Olson , Hiroyuki Oono , Lewis D. Pennington , Kosuke Sasaki , Keiko Shimada , Youngsook Shin , Ryan D. White , Ryan P. Wurz , Shuyan Yi , Xiao Mei Zheng
IPC: C07D231/14 , C07D409/12 , C07D413/12 , C07D405/14 , C07D401/14 , C07D493/08 , C07D401/12 , C07D403/12
CPC classification number: C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/14 , C07D493/08
Abstract: The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
Abstract translation: 本发明涉及具有抑制RORγ活性的新型化合物。 本发明还涉及包含该化合物的药物组合物，该化合物在治疗或预防自身免疫疾病，炎性疾病，代谢疾病或癌症疾病中的用途。
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公开(公告)号：US20130079303A1
公开(公告)日：2013-03-28
申请号：US13681230
申请日：2012-11-19
Applicant: Amgen Inc.
Inventor： Kristin L. ANDREWS , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire I.M. Jackson , Brian Alan Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian Leonard Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin C. Yang
IPC: C07D473/00 , C07D417/14 , C07D405/14 , C07D413/14 , C07D401/14
CPC classification number: C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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