公开(公告)号：US20130058944A1

公开(公告)日：2013-03-07

申请号：US13655984

申请日：2012-10-19

Applicant: Amgen Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: A61K39/395 ,  A61P3/06

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20140357854A1

公开(公告)日：2014-12-04

申请号：US14459844

申请日：2014-08-14

Applicant: Amgen Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。

公开(公告)号：US20140357853A1

公开(公告)日：2014-12-04

申请号：US14459768

申请日：2014-08-14

Applicant: Amgen Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20140357852A1

公开(公告)日：2014-12-04

申请号：US14459743

申请日：2014-08-14

Applicant: Amgen Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20140357850A1

公开(公告)日：2014-12-04

申请号：US14459777

申请日：2014-08-14

Applicant: Amgen Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20140228557A1

公开(公告)日：2014-08-14

申请号：US14261063

申请日：2014-04-24

Applicant: Amgen, Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: C12N15/113

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20130245235A1

公开(公告)日：2013-09-19

申请号：US13860016

申请日：2013-04-10

Applicant: AMGEN, INC.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US09266945B2

公开(公告)日：2016-02-23

申请号：US13794265

申请日：2013-03-11

Applicant: AMGEN INC. ,  E.R. SQUIBB & SONS, L.L.C.

Inventor： Gerald Siu ,  Wenyan Shen ,  Steven K. Yoshinaga ,  Haichun Huang

IPC: C07K16/18 ,  C07K16/28

CPC classification number: C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.

公开(公告)号：US20150031870A1

公开(公告)日：2015-01-29

申请号：US14487932

申请日：2014-09-16

Applicant: Amgen Inc.

Inventor： SIMON MARK JACKSON ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US08871914B2

公开(公告)日：2014-10-28

申请号：US14261063

申请日：2014-04-24

Applicant: Amgen, Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC: C07K16/40 ,  C07K16/00 ,  C12N15/113

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.