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公开(公告)号：US20190241586A1
公开(公告)日：2019-08-08
申请号：US16385547
申请日：2019-04-16
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US09796735B2
公开(公告)日：2017-10-24
申请号：US14536483
申请日：2014-11-07
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/387
摘要： The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
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公开(公告)号：US09353133B2
公开(公告)日：2016-05-31
申请号：US14201459
申请日：2014-03-07
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： C07F5/04 , C07F5/02 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , A61K31/69 , A61K31/70 , A61K31/7076
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20140315860A1
公开(公告)日：2014-10-23
申请号：US14221637
申请日：2014-03-21
发明人： Vincent S. HERNANDEZ , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US11008345B2
公开(公告)日：2021-05-18
申请号：US16526248
申请日：2019-07-30
发明人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号： C07F5/02
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
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公开(公告)号：US20210053999A1
公开(公告)日：2021-02-25
申请号：US17089058
申请日：2020-11-04
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20200095266A1
公开(公告)日：2020-03-26
申请号：US16695253
申请日：2019-11-26
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US10533021B2
公开(公告)日：2020-01-14
申请号：US15718422
申请日：2017-09-28
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US09889146B2
公开(公告)日：2018-02-13
申请号：US15162125
申请日：2016-05-23
IPC分类号： A61K31/69 , A61K31/195 , A61K31/198
CPC分类号： A61K31/69 , A61K31/198 , A61K2300/00
摘要： Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.
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