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157 条记录 (耗时 0.029 秒)

    Octacyclodepsipeptides having an endoparasiticidal action
    12.
    发明授权
    Octacyclodepsipeptides having an endoparasiticidal action 失效
    具有内寄生性杀伤作用的Octacyclodepsipeptide

    公开(公告)号：US06468966B1

    公开(公告)日：2002-10-22

    申请号：US08246022

    申请日：1994-05-19

    申请人： Jürgen Scherkenbeck ,  Peter Jeschke ,  Hans-Georg Lerchen ,  Hermann Hagemann ,  Achim Harder ,  Norbert Mencke ,  Andrew Plant

    发明人： Jürgen Scherkenbeck ,  Peter Jeschke ,  Hans-Georg Lerchen ,  Hermann Hagemann ,  Achim Harder ,  Norbert Mencke ,  Andrew Plant

    IPC分类号： A61K3800

    CPC分类号： C07D273/00 ,  A61K38/00 ,  C07K11/02

    摘要： The present invention relates to compounds of the general formula (I) in which R1 and R12 represent the same or different radicals selected from the group of C2-9-alkyl, C1-8-halogen-alkyl, C3-6-cycloalkyl, aralkyl or aryl, R3 to R10 represent the same or different radicals selected from the group of hydrogen, C1-5-alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a —NR13R14 group in which R13 or R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C1-4-alkyl, R2 and R11 represent the same of different radicals selected from the group of C1-4-alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R 1和R 12表示相同或不同的选自C 2-9 - 烷基，C 1-8 - 卤素 - 烷基，C 3-6 - 环烷基，芳烷基或 芳基，R 3至R 10表示选自氢，可任选被羟基，烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，硫代或硫代烷基取代的C 1-5 - 烷基的相同或不同的基团，并且表示 芳基，烷基芳基或杂芳基甲基，其任选被卤素，羟基，烷基，烷氧基，硝基或-NR 13 R 14基团取代，其中R 13或R 14彼此独立地表示氢或烷基或与相邻的氮原子一起形成5,6或 任选地被O，S或N中断并且任选被C 1-4 - 烷基取代的R 7和R 11代表与选自C 1-4 - 烷基及其立体异构体的不同基团相同的7-元环， 进行准备a 并将其用作内寄生物杀虫剂。

    Substituted 1,2,4-oxadiazole derivatives
    15.
    发明授权
    Substituted 1,2,4-oxadiazole derivatives 失效
    取代的1,2,4-恶二唑衍生物

    公开(公告)号：US5371231A

    公开(公告)日：1994-12-06

    申请号：US57584

    申请日：1993-05-05

    申请人： Peter Jeschke ,  Werner Lindner ,  Achim Harder ,  Norbert Mencke ,  Axel Haberkorn

    发明人： Peter Jeschke ,  Werner Lindner ,  Achim Harder ,  Norbert Mencke ,  Axel Haberkorn

    IPC分类号： A61K31/41 ,  A01N43/82 ,  A01N43/836 ,  A61K31/4245 ,  A61P33/00 ,  A61P33/10 ,  C07D271/06

    CPC分类号： C07D271/06 ,  A01N43/82

    摘要： The present invention relates to new substituted 1,2,4-oxadiazole derivatives of the formula (I) and to their stereoisomers ##STR1## in which formula R.sup.4 represents OH, SH, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl, halogenoalkylsulphonyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylenedioxy, halogenoalkylenedioxy, amino, alkylamino, dialkylamino, acylamino, carbamoyl, alkylsulphinyl, alkylsulphonyl, arylsuphinyl, arylsulphonyl, sulphonylamino, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxyalkyl, alkoxyalkoxy or hydroxyalkoxy, where in the event that at least one of the radicals R.sup.2 or R.sup.3 is other than hydrogen, R.sup.4 additionally represents halogen, alkyl, halogenoalkyl, alkoxy or thioalkyl, where, in the event that R.sup.1 represents optionally substituted C.sub.1-8 -alkyl, R.sup.4 additionally represents alkoxy,processes for their preparation, and their use as endoparasiticides.

    摘要翻译： 本发明涉及式（I）的新的取代的1,2,4-恶二唑衍生物及其立体异构体，其中式R4代表OH，SH，卤代烷氧基，卤代烷硫基，卤代烷基亚磺酰基，卤代烷基磺酰基，芳氧基， 芳烷氧基，芳硫基，芳烷硫基，亚烷基二氧基，卤代亚烷基二氧基，氨基，烷基氨基，二烷基氨基，酰基氨基，氨基甲酰基，烷基亚磺酰基，烷基磺酰基，芳基亚乙基，芳基磺酰基，磺酰基氨基，烷氧基羰基，烷基羰基，烷基羰基氧基，烷氧基烷基，烷氧基烷氧基或羟基烷氧基，其中在至少一个 基团R2或R3不是氢，R4另外表示卤素，烷基，卤代烷基，烷氧基或硫代烷基，其中，在R 1表示任选取代的C 1-8 - 烷基的情况下，R 4另外表示烷氧基，其制备方法， 并将其用作内寄生物杀灭剂。

    Use of substituted 1,2,4-oxadiazole derivatives for combating endoparasites, new substituted 1,2,4-oxadiazole derivatives, and processes for their preparation
    18.
    发明授权
    Use of substituted 1,2,4-oxadiazole derivatives for combating endoparasites, new substituted 1,2,4-oxadiazole derivatives, and processes for their preparation 失效
    使用取代的1,2,4-恶二唑衍生物对抗内寄生虫，新的取代的1,2,4-恶二唑衍生物及其制备方法

    公开(公告)号：US5428047A

    公开(公告)日：1995-06-27

    申请号：US124909

    申请日：1993-09-21

    申请人： Peter Jeschke ,  Werner Lindner ,  Achim Harder ,  Norbert Mencke

    发明人： Peter Jeschke ,  Werner Lindner ,  Achim Harder ,  Norbert Mencke

    IPC分类号： A01N43/82 ,  A01N43/836 ,  A61K31/41 ,  A61K31/4245 ,  A61P33/00 ,  A61P33/10 ,  C07D271/06 ,  C07D413/06

    CPC分类号： C07D271/06 ,  A01N43/82 ,  A61K31/41

    摘要： The present invention relates to the use of substituted 1,2,4-oxadiazole derivatives of the general formula I ##STR1## in which R.sup.1 represents hydrogen, alkyl which is optionally substituted by halogen, alkoxy, hydroxyl, amino, alkylamino, dialkylamino, cycloalkylamino as well as cycloalkyl, optionally substituted aryl or hetaryl,R.sup.2 represents hydrogen and alkyl,X represents O, S, SO, SO.sub.2 and N-R.sup.3,R.sup.3 represents hydrogen, alkyl, alkylcarbonyl or halogenoalkylcarbonylR.sup.4 represents identical or different radicals from the series comprising hydrogen, halogen, cyano, nitro, isothiocyanato, amino, aminoacyl, alkylamino, dialkylamino, trialkylammonium halide, sulphonylamino, hydroxyl, mercapto, alkyl, aralkyl, halogenoalkyl, alkoxy, aralkoxy, halogenoalkoxy, aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl, alkylthio, halogenoalkylthio, alkylsulphinyl, halogenoalkylsulphinyl, alkylsulphonyl, halogenoalkylsulphonyl, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxyalkyl, alkoxyalkoxy, hydroxyalkoxy, hetarylmethyleneoxy,for combating endoparasites in medicine and veterinary medicine, and new compounds of the formula (I) and their preparation.

    摘要翻译： 本发明涉及通式Ⅰ的取代的1,2,4-恶二唑衍生物（Ⅰ），其中R1代表氢，任选被卤素，烷氧基，羟基，氨基，烷基氨基， 二烷基氨基，环烷基氨基以及环烷基，任选取代的芳基或杂芳基，R 2表示氢和烷基，X表示O，S，SO，SO 2和N-R 3，R 3表示氢，烷基，烷基羰基或卤代烷基羰基R 4表示相同或不同的基团， 氨基，氨基酰基，烷基氨基，二烷基氨基，三烷基卤化铵，磺酰基氨基，羟基，巯基，烷基，芳烷基，卤代烷基，烷氧基，芳烷氧基，卤代烷氧基，芳基，芳氧基，芳硫基，芳基亚磺酰基， 芳基磺酰基，烷硫基，卤代烷硫基，烷基亚磺酰基，卤代烷基亚磺酰基，烷基磺酰基，卤代烷基磺酰基，烷氧基羰基，烷基羰基，烷基羰基氧基，烷氧基烷基，烷氧基 烷氧基，羟基烷氧基，杂芳基亚甲氧基，用于对抗医药和兽药中的内寄生虫，以及式（I）的新化合物及其制备。