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281 条记录 (耗时 0.033 秒)

    Bridged 4-phenyl-2-aminomethylimidazoles
    12.
    发明授权
    Bridged 4-phenyl-2-aminomethylimidazoles 失效
    桥接的4-苯基-2-氨基甲基咪唑

    公开(公告)号：US06211366B1

    公开(公告)日：2001-04-03

    申请号：US09371066

    申请日：1999-08-09

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： C07D40314

    CPC分类号： C07D235/02 ,  C07D403/12 ,  C07D491/04

    摘要： Disclosed are compounds encompassed by general formula (I), wherein, A represents ethenylene, or A represents —X—CH2—; where X is CH2 or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; R1, R2, R3 and R4 are inorganic or organic substituents; and R5 and R6 are optionally substituted organic substituents; or NR5R6 represents a carbocyclic or heterocyclic six-membered ring optionally substituted with various organic or inorganic groups, which compounds can be used in treatment of neuropsychological disorders.

    摘要翻译： 公开了通式（I）所包括的化合物，其中A表示亚乙烯基，或A表示-X-CH 2 - ; 其中X是CH 2或氧，条件是当X是氧时，氧与6元环相邻; R1，R2，R3和R4是无机或有机取代基; 并且R 5和R 6是任选取代的有机取代基; 或NR 5 R 6表示任选被各种有机或无机基团取代的碳环或杂环六元环，所述化合物可用于治疗神经心理障碍。

    Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
    13.
    发明授权
    Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands 失效
    某些桥接的4-苯基-2-氨基甲基咪唑; 新的多巴胺受体亚型特异性配体

    公开(公告)号：US5948912A

    公开(公告)日：1999-09-07

    申请号：US913116

    申请日：1998-01-20

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： C07D235/02 ,  C07D403/12 ,  C07D491/04 ,  C07D403/14 ,  A61K31/44 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06

    CPC分类号： C07D235/02 ,  C07D403/12 ,  C07D491/04

    摘要： Disclosed are compounds encompassed by general formula (I), wherein, A represents ethenylene, or A represents --X--CH.sub.2 --; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are inorganic or organic substituents; and R.sub.5 and R.sub.6 are optionally substituted organic substituents; or NR.sub.5 R.sub.6 represents a carbocyclic or heterocyclic six-membered ring optionally substituted with various organic or inorganic groups, which compounds can be used in the treatment of neuropsychological disorders. ##STR1##

    摘要翻译： PCT No.PCT / US96 / 01906 Sec。 371日期1998年1月20日 102（e）1998年1月20日PCT PCT 1996年2月14日PCT公布。 公开号WO96 / 25411 PCT 日期1996年8月22日公开是通式（I）所包含的化合物，其中A表示亚乙烯基，或A表示-X-CH2-; 其中X是碳或氧，条件是当X是氧时，氧与6元环相邻; R1，R2，R3和R4是无机或有机取代基; 并且R 5和R 6是任选取代的有机取代基; 或NR 5 R 6表示任选被各种有机或无机基团取代的碳环或杂环六元环，所述化合物可用于治疗神经心理障碍。

    Aminomethyl phenyl pyridine derivatives
    14.
    发明授权
    Aminomethyl phenyl pyridine derivatives 失效
    氨基甲基苯基吡啶衍生物

    公开(公告)号：US06281359B1

    公开(公告)日：2001-08-28

    申请号：US08457409

    申请日：1995-06-01

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： C07D40106

    CPC分类号： C07D239/42 ,  C07C211/27 ,  C07D211/14 ,  C07D211/70 ,  C07D295/096 ,  C07D401/06

    摘要： Disclosed are compounds of the formula: where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR′ where R′ is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1, X, Y, Z and T are organic or inorganic substituents; and R2 and R3 represent hydrogen or organic substituents; or NR2R3 together represents a heterocyclic ring system; and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

    摘要翻译： 公开了下式的化合物：其中S和V是各种有机或无机取代基; G和K相同或不同，表示N或CR'，其中R'是有机或无机取代基; R是氢或烷基; R 1 X，Y，Z和T​​是有机或无机取代基; 且R 2和R 3表示氢或有机取代基; 或NRR2R3一起表示杂环系统;及其药学上可接受的盐; 其是脑多巴胺受体亚型的高度选择性部分激动剂或拮抗剂，因此可用于诊断和治疗情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森综合征。

    Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
    15.
    发明授权
    Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands 失效
    某些桥接的4-苯基-2-氨基甲基咪唑; 新的多巴胺受体亚型特异性配体

    公开(公告)号：US5773616A

    公开(公告)日：1998-06-30

    申请号：US463759

    申请日：1995-06-05

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： C07D235/02 ,  C07D403/12 ,  C07D491/04 ,  C07D403/14 ,  C07D401/14

    CPC分类号： C07D235/02 ,  C07D403/12 ,  C07D491/04

    摘要： Disclosed are compounds encompassed by the following general formula: ##STR1## wherein, A represents ethenylene, or A represents --X--CH.sub.2 --; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are inorganic or organic substituents; and R.sub.5 and R.sub.6 is are optionally substituted organic substituents; or NR.sub.5 R.sub.6 represents a carbocyclic or heterocyclic six membered ring optionally substituted with various orgainic or inorganic groups, which compounds can be used in the treatment of neuropsychological disorders.

    摘要翻译： 公开的是由以下通式包括的化合物：其中A表示亚乙烯基，或A表示-X-CH2-; 其中X是碳或氧，条件是当X是氧时，氧与6元环相邻; R1，R2，R3和R4是无机或有机取代基; 并且R 5和R 6是任选取代的有机取代基; 或NR 5 R 6表示任选被各种有机或无机基团取代的碳环或杂环六元环，该化合物可用于治疗神经心理障碍。

    5,6-dihydro-napth[1,2-d]-imidazole, napth[1,2-d]imidazole, and chromane[3,4-d]imidazole derivatives
    16.
    发明授权
    5,6-dihydro-napth[1,2-d]-imidazole, napth[1,2-d]imidazole, and chromane[3,4-d]imidazole derivatives 有权

    公开(公告)号：US06436941B1

    公开(公告)日：2002-08-20

    申请号：US09783476

    申请日：2001-02-14

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： A61K31495

    摘要： Disclosed are 5,6-Dihydro-napth[1,2-d]-imidazoles, Naphth[1,2-d]imidazoles, and Chromane[3,4-d]imidazoles compounds having the formula: and the pharmaceutically acceptable salts thereof, wherein, A represents ethenylene, or A represents —X—CH2—; where X is CH2 or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; R1, R2, R3 and R4 are inorganic or organic substituents; and R5 and R6 is are optionally substituted organic substituents; or NR5R6 represents a carbocyclic or heterocyclic six membered ring optionally substituted with various organic or inorganic groups. Such compounds are useful in the treatment of neuropsychological disorders.

    Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
    19.
    发明授权
    Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands 失效
    某些氨基甲基联苯，氨基甲基苯基吡啶和氨基甲基苯基嘧啶衍生物; 新型多巴胺受体亚型选择性配体

    公开(公告)号：US5594141A

    公开(公告)日：1997-01-14

    申请号：US344497

    申请日：1994-11-23

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： C07C211/27 ,  C07D211/14 ,  C07D211/70 ,  C07D239/42 ,  C07D295/096 ,  C07D401/06 ,  C07D239/24 ,  C07D239/34 ,  C07D239/52

    CPC分类号： C07D239/42 ,  C07C211/27 ,  C07D211/14 ,  C07D211/70 ,  C07D295/096 ,  C07D401/06

    摘要： Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents;G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent;R is hydrogen or an alkyl group;R.sub.1, X, Y, Z and T are organic or inorganic substituents; andR.sub.2 and R.sub.3 represent hydrogen or organic substituents; orNR.sub.2 R.sub.3 together represents a heterocyclic ring system;and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

    摘要翻译： 公开了下式的化合物：其中S和V是各种有机或无机取代基; G和K相同或不同，表示N或CR'，其中R'是有机或无机取代基; R是氢或烷基; R1，X，Y，Z和T​​是有机或无机取代基; R2和R3代表氢或有机取代基; 或NR2R3一起表示杂环体系; 及其药学上可接受的盐; 其是脑多巴胺受体亚型的高度选择性部分激动剂或拮抗剂，因此可用于诊断和治疗情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森综合征。

    Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
    20.
    发明授权
    Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands 失效
    某些氨基甲基联苯，氨基甲基苯基吡啶和氨基甲基苯基嘧啶衍生物; 新型多巴胺受体亚型选择性配体

    公开(公告)号：US06221871B1

    公开(公告)日：2001-04-24

    申请号：US09330513

    申请日：1999-06-11

    申请人： Jun Yuan ,  Andrew Thurkauf

    发明人： Jun Yuan ,  Andrew Thurkauf

    IPC分类号： A61K31505

    CPC分类号： C07D239/42 ,  C07C211/27 ,  C07D211/14 ,  C07D211/70 ,  C07D295/096 ,  C07D401/06

    摘要： Disclosed are compounds of the formula: where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR′ where R′ is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1, X, Y, Z and T are organic or inorganic substituents; and R2 and R3 represent hydrogen or organic substituents; or NR2R3 together represents a heterocyclic ring system; and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

    摘要翻译： 公开了下式的化合物：其中S和V是各种有机或无机取代基; G和K相同或不同，表示N或CR'，其中R'是有机或无机取代基; R是氢或烷基; R 1 X，Y，Z和T​​是有机或无机取代基; 且R 2和R 3表示氢或有机取代基; 或NRR2R3一起表示杂环系统;及其药学上可接受的盐; 其是脑多巴胺受体亚型的高度选择性部分激动剂或拮抗剂，因此可用于诊断和治疗情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森综合征。