公开(公告)号：US20060259088A1

公开(公告)日：2006-11-16

申请号：US11129058

申请日：2005-05-13

申请人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

发明人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC分类号： A61N1/362

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/37205 ,  A61N1/3787 ,  A61N2001/0585

摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

公开(公告)号：US20060116727A1

公开(公告)日：2006-06-01

申请号：US11276007

申请日：2006-02-09

申请人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Andrew Kramer

发明人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Andrew Kramer

IPC分类号： A61N1/36

CPC分类号： A61N1/36592 ,  A61B5/0472 ,  A61N1/3627 ,  A61N1/3684

摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

摘要翻译： 用于选择一个或多个心室以刺激心室再同步治疗的方法和装置。 包括QRS复合物在内的心内电图从左心室和右心室记录。 然后确定从左心室和右心室记录的内在心内电描记图之间的时间关系。 在一个实施例中，使用左心室和右心室感测的内心室去极化之间的延迟和一个或多个QRS复合物的持续时间间隔来确定时间关系。 在一个实施方案中，QRS复合物的持续时间由心脏内电刺激图或从表面心电图记录确定。 然后基于从右心室和左心室记录的内在心内电描记图与一个或多个QRS复合物的持续时间之间的时间关系来选择其中提供起搏脉冲的一个或多个心室。

公开(公告)号：US20050131472A1

公开(公告)日：2005-06-16

申请号：US11049181

申请日：2005-02-02

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew Kramer ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20070135854A1

公开(公告)日：2007-06-14

申请号：US11674773

申请日：2007-02-14

申请人： Andrew Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

发明人： Andrew Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/3682

摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrio-ventricular delay time intervals is provided for programming the pacing system.

摘要翻译： 起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统 心室起搏脉冲的最佳时机。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。 提供了将这种电气或机械事件的时间与心房延迟时间间隔相关联的查找表，用于对起搏系统进行编程。

公开(公告)号：US20060276847A1

公开(公告)日：2006-12-07

申请号：US11463176

申请日：2006-08-08

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchorny or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 用于为诸如室性同步或收缩性（心脏收缩期左心室压力变化峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能的起搏系统或用于计算心室延迟的系统的行程体积（主动脉脉压） 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20060116728A1

公开(公告)日：2006-06-01

申请号：US11276031

申请日：2006-02-10

申请人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

发明人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/36

CPC分类号： A61N1/3622

摘要： A device and method is disclosed for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified negative offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. Techniques are presented for preventing tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.

摘要翻译： 公开了一种用于改善心律失常检测的装置和方法，当通过将指定的负偏移间隔分开的两个心室递送步调来再同步时，心律失常检测。 逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。 提出技术用于在速率心室在另一脑室之后起搏时预防快速性心律失常检测受到损害。

公开(公告)号：US20050203581A1

公开(公告)日：2005-09-15

申请号：US11125501

申请日：2005-05-10

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。

公开(公告)号：US20080046017A1

公开(公告)日：2008-02-21

申请号：US11891896

申请日：2007-08-14

申请人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

发明人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3716

摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

摘要翻译： 用于协调治疗的心律管理系统包括产生起搏和再充电脉冲放电的脉冲发生器。 耦合到脉冲发生器的脉冲传送控制器以期望的顺序对起搏的递送和再充电脉冲的放电进行倍增。 耦合到脉冲传送控制器的治疗电路接收来自脉冲传送控制器的定时脉冲，并将定时脉冲传送到设置在心脏中或周围的一个或多个电极，以将定时起搏和再充电脉冲的放电传达到不同部位 心脏，以避免由协调治疗所需的多个位置起搏期间由电极周围的电场引起的任何相互作用。

公开(公告)号：US20070054871A1

公开(公告)日：2007-03-08

申请号：US11220397

申请日：2005-09-06

申请人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

发明人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61K48/00 ,  A61N1/00

CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

公开(公告)号：US20050131480A1

公开(公告)日：2005-06-16

申请号：US10735267

申请日：2003-12-12

申请人： Andrew Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

发明人： Andrew Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio Spinelli

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/3682

摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrioventricular delay time intervals is provided for programming the pacing system.

摘要翻译： 起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统 心室起搏脉冲的最佳时机。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。 提供了将这种电气或机械事件的时间与房室延迟时间间隔相关联的查找表用于对起搏系统进行编程。