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公开(公告)号：US10967154B2
公开(公告)日：2021-04-06
申请号：US16078388
申请日：2017-02-21
Inventor： Jeffrey LaBelle , Julio Morera , Marco Santello
IPC: A61M25/09
Abstract: Guidewires useful for cooperating with catheters may be actively steered and/or provide adjustable stiffness. Angle or curvature of a guidewire, and/or flexural modulus of a guidewire, may be adjusted at one or more locations between ends thereof. Variable stiffness segments may include electrically operated compressible and/or extensible materials. Multiple tensile elements may terminate at different body elements to adjust angle or curvature at multiple locations. Multiple circumferentially and/or radially contractible fiber regions may be provided and distributed over a length of a guidewire. Adjustable flexure elements arranged in or along a guidewire may be electrically operated. A flexible core member may be centrally arranged in a tubular body. A flexible guide wire or track may cooperate with electrically operable motor units.
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公开(公告)号：US20190328315A1
公开(公告)日：2019-10-31
申请号：US16396258
申请日：2019-04-26
Applicant: Megan Wieser , Jinglin Liu , Amanda Smith , Priscilla Hernandez , Arizona Board of Regents on Behalf of Arizona State University
Inventor： Jeffrey LaBelle , Megan Wieser , Jinglin Liu , Amanda Smith , Priscilla Hernandez
Abstract: Systems, devices and methods involving static or active measurement of pressure, load, or other forces exerted on or between internal anatomical structures are described. A load and/or strain sensor, which may be implantable or otherwise deployed during a medical procedure, along with systems and methods thereof, are also described. These measurements techniques and sensors can provide real-time as well as accumulated data indicative of stresses or other forces being exerted on or between internal anatomical structures of a target patient, e.g., portions or interfaces of the skeletal system.
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公开(公告)号：US10323008B2
公开(公告)日：2019-06-18
申请号：US15316468
申请日：2015-06-05
Inventor： Jeffrey LaBelle , Trevor Saxman , Brittney Haselwood
IPC: C08G73/02 , C08G83/00 , G01N33/66 , C07D245/04
Abstract: Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.
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14.发明申请公开(公告)号：US20190160206A1
公开(公告)日：2019-05-30
申请号：US16200824
申请日：2018-11-27
Inventor： Steven Lathers , Jeffrey LaBelle
Abstract: A thermally responsive shape memory polymer (SMP) actuator includes a body having at least one non-linear segment arranged between first and second ends, with the body comprising a plurality of dots, rods, or layers of SMP material. The SMP material my include a linear aliphatic thermoplastic polyester and at least one other polymer. The non-linear segment may have a substantially flat zig-zag shape arranged between first and second substantially straight segments. A prosthetic device may include multiple thermally responsive shape memory actuators and a movable joint arranged between structural members having anchors associated therewith. A first group of SMP actuators provides pivotal movement in a first direction, and a second group of SMP actuators provides pivotal movement in a second direction. Methods for forming SMP actuators include body formation by additive manufacturing, heating the body to a glass transition temperature range while applying tension, and cooling the body.
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公开(公告)号：US20190024131A1
公开(公告)日：2019-01-24
申请号：US16068877
申请日：2017-01-27
Inventor： Jeffrey LaBelle , Chi Lin , Jonus Reyna , Amnah Alkhan , Cael Muggeridge , Susan Sheffield
IPC: C12Q1/00 , G01N27/327
CPC classification number: C12Q1/006 , A61B5/14532 , G01N27/31 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N27/70
Abstract: Devices and methods capable of detecting glucose in saliva (FIG. 12). The devices feature a sensor having a substrate containing electrodes and one or more reagents on the electrodes. A detection device is operably coupled with the sensor to detect glucose based on measurement of an electrical parameter when electricity is applied to the electrode.
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Patent Agency Ranking
16.发明申请公开(公告)号：US20210223196A1
公开(公告)日：2021-07-22
申请号：US16612270
申请日：2018-05-04
Applicant: Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDAION FOR MEDICAL EDUCATION AND RESEARCH
Inventor： Jeffrey LaBelle , Garrett Repp , Chi Lin , Mark Spano , Jennifer Blain Christen , Hongwu Jiang , Marcus Smith , Andrew Penman , Pierce Youngbar , Mackenzie Honikel , Curtiss Cook
IPC: G01N27/02 , G01N27/327 , G01N33/487 , G01N27/22 , G01N35/00 , G01N33/569 , G01N33/66 , G01N33/53
Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.
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公开(公告)号：US10775301B2
公开(公告)日：2020-09-15
申请号：US15546790
申请日：2016-02-03
Inventor： Jeffrey LaBelle
Abstract: Methods and apparatus relating to light amplification technology that has the ability to transform and amplify light to be seen in the visible spectrum by the user (FIG. 2). The biologically-based light amplification system including a reaction center, a proton gradient area, and a light amplification area, and may be configured such that light entering the system through the reaction center produces a proton gradient, which in turn acts upon reactants in the proton gradient area, and then causes a product to enter the light amplification area and thereby drive a bioluminescent or phosphorescent reaction to amplify the light The methods and apparatus use solely biological processes without any external power supply.
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公开(公告)号：US20200276030A1
公开(公告)日：2020-09-03
申请号：US16806418
申请日：2020-03-02
Inventor： Jeffrey LaBelle , Courtney Mason
Abstract: A prosthetic device includes an internal frame assembled from multiple longitudinal members and multiple transverse members that are substantially planar in character and are arranged to be joined together. A medially arranged opening is defined in each transverse member, and is substantially registered with openings of adjacent transverse members to form a longitudinal passage, such as may be useful to receive an actuator and/or other items. At least some transverse members differ from one another in one or more of shape, length, or width. A covering member may be provided over the internal frame. Rear-facing gaps in transverse members may receive one or more elements such as dampers, batteries, or the like.
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公开(公告)号：US10386321B2
公开(公告)日：2019-08-20
申请号：US15503364
申请日：2015-07-27
Inventor： Jeffrey LaBelle , Tina Hakimi , Brittney Cardinell
IPC: G01N27/327 , G01N33/543 , A61B5/145 , G01N27/02 , G01N27/30 , G01N33/74 , A61B5/053 , A61B5/16
Abstract: Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as Cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and 10 mM N-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of detection of 18.73 pM and less than 10% relative standard deviation.
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公开(公告)号：US10219918B2
公开(公告)日：2019-03-05
申请号：US15257462
申请日：2016-09-06
Inventor： Jeffrey LaBelle , Sarah McBryan
Abstract: A prosthetic device including an internal frame assembled from multiple longitudinal members and multiple transverse members, wherein each member is substantially planar and defines peripheral slots, and wherein the longitudinal members and transverse members are arranged to mate with one another to join the longitudinal members with the transverse members. In certain embodiments, a first group of longitudinal members is radially arranged relative to a central axis extending through the transverse members, and a second group of longitudinal members is tangentially arranged relative to the central axis, preferably with lateral edges of the second group of longitudinal members extending between two different longitudinal members of the first group of longitudinal members to provide enhanced torsional rigidity. An outer shaping member, which may be tubular in shape, may be arranged to cover at least a portion of the internal frame.
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