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61 条记录 (耗时 0.042 秒)

    Immunostimulatory nucleic acids for inducing IL-10 responses
    11.
    发明申请
    Immunostimulatory nucleic acids for inducing IL-10 responses 审中-公开
    用于诱导IL-10反应的免疫刺激核酸

    公开(公告)号：US20060019916A1

    公开(公告)日：2006-01-26

    申请号：US11099683

    申请日：2005-04-04

    申请人： Arthur Krieg ,  Jorg Vollmer

    发明人： Arthur Krieg ,  Jorg Vollmer

    IPC分类号： A61K48/00 ,  C07H21/04

    CPC分类号： C12N15/117 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/04 ,  C12N2310/17 ,  C12N2310/315 ,  Y02A50/401

    摘要： The invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-α expression. IL-10-inducing immunostimulatory nucleic acids preferably include a TC dinucleotide at the 5′ end and a CG dinucleotide towards the 3′ end, but not near the 5′ end. The invention is useful for treating and preventing disorders associated with a Th1 or Th2 immune response or for promoting a T regulatory cell environment suitable for suppressing inappropriate immune responses (e.g., for controlling or suppressing excessive immune responses).

    摘要翻译： 本发明涉及使用免疫刺激核酸诱导IL-10表达的方法和产品。 特别地，本发明涉及用于诱导IL-10表达而不诱导高水平IFN-α表达的方法和产物。 IL-10诱导免疫刺激性核酸优选包括5'末端的TC二核苷酸和朝向3'末端但不在5'端附近的CG二核苷酸。 本发明可用于治疗和预防与Th1或Th2免疫应答有关的紊乱或用于促进适于抑制不适当免疫应答的T调节细胞环境（例如用于控制或抑制过度免疫应答）。

    Immunomodulatory oligonucleotides
    13.
    发明申请
    Immunomodulatory oligonucleotides 失效

    公开(公告)号：US20070010470A9

    公开(公告)日：2007-01-11

    申请号：US11127797

    申请日：2005-05-11

    申请人： Arthur Krieg ,  Dennis Klinman ,  Alfred Steinberg

    发明人： Arthur Krieg ,  Dennis Klinman ,  Alfred Steinberg

    IPC分类号： C07H21/02 ,  A61K48/00

    CPC分类号： A61K31/4706 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/00 ,  C12Q1/68

    摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.

    Methods related to immunostimulatory nucleic acid-induced interferon
    14.
    发明申请
    Methods related to immunostimulatory nucleic acid-induced interferon 失效
    与免疫刺激核酸诱导干扰素相关的方法

    公开(公告)号：US20060286070A1

    公开(公告)日：2006-12-21

    申请号：US11179008

    申请日：2005-07-08

    申请人： Gunther Hartmann ,  Robert Bratzler ,  Arthur Krieg

    发明人： Gunther Hartmann ,  Robert Bratzler ,  Arthur Krieg

    IPC分类号： A61K48/00 ,  A61K38/21

    CPC分类号： C12N15/117 ,  A61K38/21 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55561 ,  C12N5/0639 ,  C12N2501/056 ,  C12N2501/22 ,  C12N2501/23 ,  A61K2300/00

    摘要： Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.

    摘要翻译： 提供了方法和组合物，用于延长IFN-α在治疗各种病毒和增殖性疾病中的临床效用。 在其它方面，本发明提供了增加IFN-α治疗功效并降低IFN-α治疗相关副作用的方法。 此外，提供了用于在体外支持生存和激活天然干扰素产生细胞（IPC）的方法，而没有外源性IL-3或GM-CSF的方法。 本发明基于某些CpG和非CpG ISNA促进IPC的存活和刺激的发现。