公开(公告)号：US07614568B2

公开(公告)日：2009-11-10

申请号：US10868203

申请日：2004-06-14

申请人： Ashok V. Joshi ,  Truman Wold ,  John J. McEvoy

发明人： Ashok V. Joshi ,  Truman Wold ,  John J. McEvoy

IPC分类号： A61L9/04

CPC分类号： A61L9/037 ,  A61L9/122 ,  A61L9/127

摘要： A device for controllably releasing a fluid into an ambient environment. According to a particular embodiment of the present invention, the device comprises a housing having a fluid compartment and an orifice compartment disposed adjacent thereto and in fluid communication therewith via an orifice. The fluid compartment contains the fluid for release to the ambient environment. The orifice compartment includes a fluid exit opening covered by a removable sealing element and contains an initial quantity of fluid when the device is in an inactivated state. A fluid restrictor is disposed adjacent the orifice to restrict fluid flow from the fluid compartment into the orifice compartment in the inactivated state. A gas-generating cell is in selective communication with the fluid compartment such that gas generated by the cell is directed into the fluid compartment when the device is in an activated state. A fluid membrane is disposed between the gas-generating cell and the fluid compartment that allows the gas generated by the cell to pass therethrough to the fluid compartment in the activated state while preventing fluid within the fluid container from passing therethrough to the cell in the inactivated state. The device is activated by removing the sealing element to allow the initial quantity of fluid to exit out of the orifice compartment via the fluid exit opening and activating the cell to generate gas and force fluid from the fluid compartment to the orifice compartment and out the fluid exit opening in a controlled manner.

摘要翻译： 用于将流体可控地释放到周围环境中的装置。 根据本发明的特定实施例，该装置包括具有流体隔室和邻近其设置并通过孔流体连通的孔室的壳体。 流体室包含用于释放到周围环境的流体。 孔室包括由可移除的密封元件覆盖的流体出口，并且当装置处于非活动状态时包含初始量的流体。 流体限制器设置在孔口附近以限制处于非活动状态的流体从流体隔室流入孔室。 气体发生电池与流体室选择性地连通，使得当该装置处于激活状态时，电池产生的气体被引导到流体室中。 流体膜设置在气体发生池和流体隔室之间，其允许由活化的细胞产生的气体通过其流到腔室中，同时防止流体容器内的流体通过其进入灭活的细胞 州。 该装置通过移除密封元件而被激活，以允许初始量的流体经由流体出口开口离开孔室，并激活电池以产生气体并迫使流体从流体隔室流到孔室并流出流体 以受控的方式出口。

公开(公告)号：US20090255451A1

公开(公告)日：2009-10-15

申请号：US12100982

申请日：2008-04-10

申请人： Truman Wold ,  Ashok V. Joshi ,  Sai Bhavaraju

发明人： Truman Wold ,  Ashok V. Joshi ,  Sai Bhavaraju

IPC分类号： A01C23/02

CPC分类号： A01G27/006 ,  A01G29/00

摘要： An apparatus for delivering a beneficial agent to a subterranean location is disclosed in one embodiment of the invention as including a water collection chamber having a substantially open end. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent such as fertilizer, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled from the subterranean delivery channel.

摘要翻译： 在本发明的一个实施例中公开了一种用于将有益剂递送到地下位置的装置，包括具有基本开口端的水收集室。 提供水输送膜以与收集室连通。 提取室通过水输送膜接收水，使提取室膨胀。 包含有益剂例如肥料的分配室被构造成在膨胀提取室时收缩。 这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。 在某些实施方案中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂从地下输送通道排出的速率。

公开(公告)号：US20120267389A1

公开(公告)日：2012-10-25

申请号：US13523015

申请日：2012-06-14

申请人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

发明人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

IPC分类号： B67D7/76

CPC分类号： A01M1/2044 ,  A61L9/12 ,  C02F1/001 ,  C02F1/28 ,  C02F1/44 ,  C02F1/68 ,  C02F1/686

摘要： An apparatus for providing controlled delivery of a beneficial agent is disclosed. In one embodiment, such an apparatus includes a water chamber and a filter to produce filtered water by removing impurities from water introduced into the water chamber. A water-transporting membrane transports filtered water from the water chamber to an extraction chamber, thereby expanding the extraction chamber. The extraction chamber contains an osmagent that provides the driving force to pull the filtered water through the water-transporting membrane. As the extraction chamber expands, a dispensing chamber containing a beneficial agent contracts. This causes the beneficial agent to be expelled through a port in communication with the dispensing chamber. A corresponding method is also disclosed.

摘要翻译： 公开了一种用于提供有益药物受控输送的装置。 在一个实施例中，这种装置包括水室和过滤器，以通过从引入水室的水中除去杂质来产生​​过滤水。 水输送膜将过滤的水从水室输送到提取室，从而使提取室膨胀。 提取室包含一个渗透剂，其提供驱动力以将过滤的水拉过水输送膜。 当提取室膨胀时，含有有益代理的分配室合同。 这使得有益剂通过与分配室连通的端口排出。 还公开了相应的方法。

公开(公告)号：US06283461B1

公开(公告)日：2001-09-04

申请号：US09330907

申请日：1999-06-11

申请人： Ashok V. Joshi ,  Truman Wold ,  John Joseph McEvoy

发明人： Ashok V. Joshi ,  Truman Wold ,  John Joseph McEvoy

IPC分类号： B01F304

CPC分类号： A01M1/2038 ,  A01M1/2033 ,  A01M1/2044 ,  A01M1/2072 ,  A01M1/2077 ,  A01M29/12 ,  A61L9/03 ,  A61L9/042 ,  A61L9/12 ,  B05B1/3006 ,  B05B7/0075 ,  B05B9/002 ,  B05B9/04 ,  Y10S261/65 ,  Y10S261/88 ,  Y10S261/89

摘要： A fluid delivery device including a container for holding a predetermined quantity of fluid, a gas generator for generating gas within the container, and a dispenser for cyclically dispensing fluid at predetermined intervals out of the container without cyclical actuation by a user.

摘要翻译： 流体输送装置，包括用于保持预定量的流体的容器，用于在容器内产生气体的气体发生器，以及分配器，用于以预定的间隔从容器中循环地分配流体，而不会由使用者循环致动。

公开(公告)号：US5954268A

公开(公告)日：1999-09-21

申请号：US139446

申请日：1998-08-25

申请人： Ashok V. Joshi ,  John H. Gordon ,  Giorgio di Palma ,  John I. McEvoy ,  Truman Wold

发明人： Ashok V. Joshi ,  John H. Gordon ,  Giorgio di Palma ,  John I. McEvoy ,  Truman Wold

IPC分类号： A61L9/12 ,  A24F25/00

CPC分类号： A61L9/12

摘要： A fluid delivery apparatus includes a housing having an open end and an interior surface. The interior of the housing defines a cavity within the housing. The cavity, in combination with a piston-like member, defines a reservoir for containing a fluid (e.g. such as an aromatic or other solvent or a solvent in which has been dissolved an aromatic substance). The piston has a port, and fits in piston-like arrangement within a cylinder contained within the housing. The piston moves within the housing, and movement of the piston acts to displace fluid from the port upon contraction of the reservoir (e.g. when the annular piston is driven into the device). Preferably, a fluid tight membrane covers the housing's open end. The apparatus also preferably further includes a conduit to transport fluid from the housing of the reservoir. The conduit has, on a first end, an exterior circumference sized and shaped to interact with the port of the annular member. On the second end of the conduit is preferably associated a sponge, wick or equivalent fragrance dispenser.

摘要翻译： 流体输送装置包括具有开口端和内表面的壳体。 壳体的内部限定了壳体内的空腔。 空腔与活塞状构件组合，限定用于容纳流体（例如其中溶解有芳族物质的芳族或其它溶剂或溶剂）的储存器。 活塞具有一个端口，并且适合在容纳在壳体内的圆柱体内的活塞状布置。 活塞在壳体内移动，并且当储存器收缩时（例如当环形活塞被驱动到装置中时），活塞的运动用于使流体从端口移位。 优选地，流体密封膜覆盖壳体的开口端。 该装置还优选地还包括用于从储存器的壳体输送流体的导管。 导管在第一端具有尺寸和形状以与环形构件的端口相互作用的外圆周。 在导管的第二端优选地与海绵，芯或等效的香料分配器相关联。

公开(公告)号：US5785688A

公开(公告)日：1998-07-28

申请号：US646069

申请日：1996-05-07

申请人： Ashok V. Joshi ,  James O. Davis ,  Truman Wold ,  Giorgio di Palma

发明人： Ashok V. Joshi ,  James O. Davis ,  Truman Wold ,  Giorgio di Palma

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M35/00 ,  A61M37/00

CPC分类号： A61M5/14593 ,  A61M2005/14204 ,  A61M2005/14252 ,  A61M35/006 ,  A61M5/14244 ,  A61M5/14248

摘要： An apparatus (120) useful for, among other things, subcutaneous drug delivery includes a housing (124), a fluid reservoir (154) disposed within the housing for storing the fluid, a pump or pressurized chamber for pressurizing a driving gas and exerting a force on the fluid reservoir to expel the fluid reservoir's contents, and a needle (150) or absorbent pad fluidically communicating with the reservoir. The apparatus may further include a pump activation mechanism such as a button and an electrical circuit such that pushing the button activates a circuit and connects a battery (138) to a pump (126), and a pump control mechanism such as electrical circuitry to control the voltage gradient to a pump to control fluid delivery.

摘要翻译： 用于（其中包括）皮下药物递送的装置（120）包括壳体（124），设置在壳体内用于储存流体的流体储存器（154），用于对驱动气体加压并施加压力的泵 流体储存器上的力被排出流体储存器的内容物，以及与储存器流体连通的针（150）或吸收垫。 该设备还可以包括诸如按钮和电路的泵激活机构，使得按下按钮激活电路并将电池（138）连接到泵（126），以及诸如电路的泵控制机构来控制 泵的电压梯度来控制流体输送。

公开(公告)号：US08353426B2

公开(公告)日：2013-01-15

申请号：US13323332

申请日：2011-12-12

申请人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

发明人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

IPC分类号： G01F11/00

CPC分类号： A61M5/14526 ,  A61L9/12 ,  A61L2209/132 ,  A61M5/14244 ,  A61M11/007 ,  A61M2005/14204 ,  A61M2005/14513 ,  A61M2205/3368 ,  A61M2205/8206 ,  A61M2205/8231 ,  B05B11/025 ,  B05B11/04 ,  B05B11/061

摘要： A method of dispensing a fluid comprising generating a gas from a liquid, directing the gas to an expandable gas chamber to expand a volume of the expandable gas chamber, reducing a volume of a fluid chamber in response to expansion of the expandable gas chamber to dispense an amount of the fluid from the fluid chamber, and removing the gas from the expandable gas chamber to collapse the expandable gas chamber.

摘要翻译： 一种分配流体的方法，包括从液体产生气体，将气体引导到可膨胀气体室以膨胀可膨胀气体室的体积，响应于可扩张气体室的扩张而减少流体室的体积以分配 来自流体室的流体的量，以及从可膨胀气体室移除气体以使可膨胀气体室折叠。

公开(公告)号：US08240261B2

公开(公告)日：2012-08-14

申请号：US13281288

申请日：2011-10-25

申请人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

发明人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

IPC分类号： A01C23/02

CPC分类号： A01M1/2044 ,  A61L9/12 ,  Y10T137/2931

摘要： A method for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The method features steady rate performance without refreshing the water chamber and low temperature sensitivity.

摘要翻译： 在本发明的一个实施例中公开了一种递送有益剂的方法，包括一个收水室。 提供水输送膜以与收集室连通。 提取室通过水输送膜接收水，使提取室膨胀。 包含有益剂的分配腔被构造成在膨胀提取室时收缩。 这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。 在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。 水输送膜具有排斥渗透到收集室的特征。 该方法具有稳定的速率性能，无需刷新水箱和低温灵敏度。

公开(公告)号：US20120145742A1

公开(公告)日：2012-06-14

申请号：US13323332

申请日：2011-12-12

申请人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

发明人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

IPC分类号： G01F11/04

CPC分类号： A61M5/14526 ,  A61L9/12 ,  A61L2209/132 ,  A61M5/14244 ,  A61M11/007 ,  A61M2005/14204 ,  A61M2005/14513 ,  A61M2205/3368 ,  A61M2205/8206 ,  A61M2205/8231 ,  B05B11/025 ,  B05B11/04 ,  B05B11/061

摘要： A method of dispensing a fluid comprising generating a gas from a liquid, directing the gas to an expandable gas chamber to expand a volume of the expandable gas chamber, reducing a volume of a fluid chamber in response to expansion of the expandable gas chamber to dispense an amount of the fluid from the fluid chamber, and removing the gas from the expandable gas chamber to collapse the expandable gas chamber.

摘要翻译： 一种分配流体的方法，包括从液体产生气体，将气体引导到可膨胀气体室以膨胀可膨胀气体室的体积，响应于可扩张气体室的扩张而减少流体室的体积以分配 来自流体室的流体的量，以及从可膨胀气体室移除气体以使可膨胀气体室折叠。

公开(公告)号：US20100176214A1

公开(公告)日：2010-07-15

申请号：US12686293

申请日：2010-01-12

申请人： Ashok V. Joshi ,  Truman Wold

发明人： Ashok V. Joshi ,  Truman Wold

IPC分类号： A61L9/04

CPC分类号： A61L9/12 ,  A45D34/00 ,  A61L9/03 ,  A61L9/122 ,  B42D15/027 ,  B42D15/042 ,  B42P2221/08

摘要： A fragrance delivery system for delivering a fragrance from a card is disclosed. In the system, a canister attached to a first surface, which may be the face of a card. An emanator is disposed within the canister, including a fragrance-emitting material. A removable cover is attached to a second surface, which may be an opposing face of the card, such that the when the first and second surfaces are brought together, the cover inhibits or prevents fragrance from escaping the canister. Upon opening the card, the cover is removed and fragrance escapes from the canister.

摘要翻译： 公开了一种用于从卡片传送香料的香味递送系统。 在系统中，连接到第一表面的罐，其可以是卡的表面。 发泡器设置在罐内，包括发出香味的材料。 可移除的盖子附接到第二表面，第二表面可以是卡的相对面，使得当第一和第二表面被接合在一起时，盖子禁止或防止香料从罐中逸出。 打开卡片后，盖子被取出，香味从罐中逸出。