公开(公告)号：US20150133463A1

公开(公告)日：2015-05-14

申请号：US14406339

申请日：2013-06-13

Applicant: BASF SE

Inventor： Tiziana Chiodo ,  Andreas Hafner ,  Tobias Hintermann ,  Beate Salvador ,  Martin Szelagiewicz ,  Fritz Blatter ,  Bernd Siebenhaar ,  Marcus Vossen

IPC: C07D417/12 ,  C07D213/82 ,  A61K31/506 ,  C07C47/58 ,  C07C35/12 ,  C07C65/03 ,  C07D309/40

CPC classification number: C07D417/12 ,  A61K31/506 ,  C07B2200/07 ,  C07B2200/13 ,  C07C35/12 ,  C07C47/58 ,  C07C65/03 ,  C07C69/84 ,  C07D213/82 ,  C07D309/40 ,  A61K2300/00

Abstract: Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(−)-menthol.

Abstract translation: 提供多组分结晶体（共晶体）及其用途，以及获得该组合物的方法。 所述多组分结晶体（共晶体）包含达沙替尼和选自甲基 - 羟基苯甲酸甲酯，烟酰胺，没食子酸乙酯，没食子酸甲酯，没食子酸丙酯，乙基麦芽酚，香草醛，薄荷醇或（1R，2S，5R） - （ - ） - 薄荷脑

公开(公告)号：US20150126520A1

公开(公告)日：2015-05-07

申请号：US14406264

申请日：2013-06-18

Applicant: BASF SE

Inventor： Tiziana Chiodo ,  Rolf Hellmann ,  Marcus Vossen ,  Beate Salvador ,  Andreas Hafner ,  Tobias Hintermann

IPC: C07D401/04 ,  C07C55/10 ,  C07C57/15 ,  C07C63/06

CPC classification number: C07D401/04 ,  C07B2200/13 ,  C07C55/10 ,  C07C57/15 ,  C07C63/06

Abstract: Novel solid forms of imatinib mesilate comprising as active ingredient 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-benzamide methanesulfonic acid salt and as co-crystal former benzoic acid, fumaric acid or succinic acid are described. The said multi-component crystalline forms possess improved physical and biological properties with respect to the crystalline forms of the active pharmaceutical ingredient previously known.

Abstract translation: 包含作为活性成分的4 - [（4-甲基-1-哌嗪基）甲基] -N- [4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基] - 苯基] - 苯甲酰胺甲磺酸盐和共结晶前体苯甲酸，富马酸或琥珀酸。 所述多组分结晶形式相对于先前已知的活性药物成分的结晶形式具有改善的物理和生物学性质。

公开(公告)号：US09527743B2

公开(公告)日：2016-12-27

申请号：US14428488

申请日：2013-09-04

Applicant: BASF SE ,  EMPA—Eidgenossische Materialprufungs- und Forschungsanstalt

Inventor： Tobias Hintermann ,  Roman Fasel ,  Pascal Ruffieux ,  Jinming Cai ,  Juan Ramon Sanchez Valencia

IPC: C01B31/04 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C01B31/0446 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/184 ,  C01B2204/06

Abstract: The present invention relates to a process for preparing a graphene nanoribbon, which comprises: (a) providing at least one aromatic monomer compound which is selected from at least one polycyclic aromatic monomer compound, at least one oligo phenylene aromatic monomer compound, or combinations thereof, on a solid substrate, (b) polymerization of the aromatic monomer compound so as to form at least one polymer on the surface of the solid substrate, (c) at least partially cyclodehydrogenating the one or more polymers of step (b), wherein at least step (b) is carried out at a total pressure p(total) of at least 1×10−9 mbar; and a partial oxygen pressure p(O2) and partial water pressure p(H2O) which satisfy the following relation: p(O2)×p(H20)

Abstract translation: 本发明涉及一种制备石墨烯纳米棒的方法，其包括：（a）提供至少一种选自至少一种多环芳族单体化合物，至少一种低聚亚苯基芳族单体化合物或其组合的芳族单体化合物 （b）芳族单体化合物的聚合以在固体基质的表面上形成至少一种聚合物，（c）至少部分地将步骤（b）的一种或多种聚合物环化脱氢，其中 至少步骤（b）以至少1×10 -9毫巴的总压力p（总计）进行; 和满足以下关系的部分氧气压力p（O2）和部分水压p（H2O）：p（O2）×p（H20）<3×10-14 mbar2。

公开(公告)号：US09339832B2

公开(公告)日：2016-05-17

申请号：US13827142

申请日：2013-03-14

Applicant: BASF SE

Inventor： Wolfgang Schrof ,  Thomas Meier ,  Christian Michael Jung ,  Antoine Carroy ,  Werner-Alfons Jung ,  Peter Hoffmann ,  Tobias Hintermann ,  Caroline Lordelot ,  Olof Wallquist

IPC: B05C9/10 ,  B05D3/06 ,  B05B7/02 ,  B05B15/00 ,  B05D1/02 ,  B05B7/22 ,  B05B1/30 ,  B05B7/04 ,  C09D4/00 ,  C09D175/04

CPC classification number: B05B15/00 ,  B05B1/3046 ,  B05B7/0441 ,  B05B7/228 ,  B05C9/10 ,  B05D1/02 ,  B05D3/06 ,  B05D3/061 ,  C09D4/00 ,  C09D175/04

Abstract: Described is a method and an apparatus for producing cured coating films on a substrate surface. Specifically, a portable spraygun may be used to initiate radiation cure without the operative having to be protected from radiation. The spraygun comprises a supply channel for a radiation-curable coating composition, a needle, a reserve for the radiation-curable coating composition, and, optionally, a supply channel for a gas.

Abstract translation: 描述了在基材表面上生产固化涂膜的方法和设备。 具体来说，可以使用便携式喷枪来启动辐射固化，而不必保护操作者免受辐射。 喷枪包括用于可辐射固化涂料组合物的供应通道，针，可辐射固化涂料组合物的储备，以及任选的用于气体的供应通道。

公开(公告)号：US20150175544A1

公开(公告)日：2015-06-25

申请号：US14415875

申请日：2013-08-05

Applicant: BASF SE

Inventor： Andreas Hafner ,  Fritz Blatter ,  Eva Roedel ,  Martin Szelagiewicz ,  Tiziana Chiodo ,  Tobias Hintermann ,  Beate Salvador ,  Marcus Vossen

IPC: C07D213/81 ,  C07D249/08

CPC classification number: C07D213/81 ,  C07B2200/13 ,  C07D249/08

Abstract: The present invention refers to a multicomponent crystalline system (co-crystal) comprising a compound of formula (1) (4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; INN: Deferasirox) formula (1) and a compound of formula (2) (Isonicotinamide; pyridine-4-carboxamide) formula (2), as well as to a process for obtaining the same.

Abstract translation: 本发明涉及包含式（1）化合物（4- [3,5-双（2-羟基苯基）-1H-1,2,4-三唑-1-基）的多组分结晶体（共晶体） ]苯甲酸; INN：Deferasirox）式（1）和式（2）化合物（异烟酰胺;吡啶-4-甲酰胺）式（2），以及其获得方法。

公开(公告)号：US20130251911A1

公开(公告)日：2013-09-26

申请号：US13827142

申请日：2013-03-14

Applicant: BASF SE

Inventor： Wolfgang SCHROF ,  Thomas Meier ,  Christian Michael Jung ,  Antoine Carroy ,  Werner-Alfons Jung ,  Peter Hoffmann ,  Tobias Hintermann ,  Caroline Lordelot ,  Olof Wallquist

IPC: B05B15/00

CPC classification number: B05B15/00 ,  B05B1/3046 ,  B05B7/0441 ,  B05B7/228 ,  B05C9/10 ,  B05D1/02 ,  B05D3/06 ,  B05D3/061 ,  C09D4/00 ,  C09D175/04

Abstract: The present invention relates to a method and an apparatus for producing cured coating films on a substrate surface.

Abstract translation: 本发明涉及一种在基材表面上生产固化涂膜的方法和设备。

公开(公告)号：US11209142B2

公开(公告)日：2021-12-28

申请号：US16897573

申请日：2020-06-10

Applicant: BASF SE

Inventor： Tobias Hintermann ,  Patrice Bujard ,  Andre Kostro ,  Adrian Von Muehlenen ,  Cristobal Garrido Segura

IPC: F21S11/00 ,  F21V8/00 ,  E04C1/42 ,  E04D13/03 ,  E04C2/54 ,  E04D3/06

Abstract: A daylight illumination system for integration into a building or larger vehicle comprises a translucent facade element (800) containing a glass sheet and a light redirection element (302 or 708), and a light transport channel (801) for guiding light about horizontally into an interior of the building, the light transport channel comprising one opening attached to the interior side of said facade element and at least one opening towards the interior of the building, characterised in that the light redirection element (302 or 708) is formed as a structured polymer film or sheet attached to a glass sheet of the facade element (800) and is configured for changing the direction of incident light into the about horizontal light transport channel.

公开(公告)号：US10794557B2

公开(公告)日：2020-10-06

申请号：US16346606

申请日：2017-11-02

Applicant: BASF SE

Inventor： Cristobal Garrido Segura ,  Tobias Hintermann ,  Andre Kostro ,  Tatjana Vetter

IPC: F21S11/00 ,  E04C1/42 ,  F21V8/00 ,  E04D13/03 ,  E04C2/54

Abstract: A daylighting panel for integration into a building or larger vehicle comprises a translucent facade element (800) containing a glass sheet and a light transport channel (801) for guiding light about horizontally into an interior of the building, the light transport channel comprising one opening attached to the interior side of said facade element and at least one opening towards the interior of the building equipped with a luminaire (807), characterised in that the inner walls including the rear end are covered by a reflecting layer (808).

公开(公告)号：US10045998B2

公开(公告)日：2018-08-14

申请号：US15103146

申请日：2014-12-09

Applicant: BASF SE

Inventor： Tiziana Chiodo ,  Beate Salvador ,  Marcus Vossen ,  Andreas Hafner ,  Tobias Hintermann ,  Martin Szelagiewicz ,  Fritz Blatter ,  Martin Viertelhaus ,  Walter Weishaar

IPC: A61K31/58 ,  A61K9/14 ,  C07J43/00

Abstract: Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acid are useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.

公开(公告)号：US09884857B2

公开(公告)日：2018-02-06

申请号：US14906974

申请日：2014-07-22

Applicant: BASF SE

Inventor： Andreas Hafner ,  Fritz Blatter ,  Martin Szelagiewicz ,  Bernd Siebenhaar ,  Tiziana Chiodo ,  Tobias Hintermann ,  Beate Salvador ,  Marcus Vossen

IPC: C07D417/12 ,  C07D275/06 ,  C07D213/80 ,  C07C55/12

CPC classification number: C07D417/12 ,  C07C55/12 ,  C07D213/80 ,  C07D275/06

Abstract: The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation of a compound of formula 1 and an anion of a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin. The invention is further related to pharmaceutical compositions comprising such a salt. Furthermore, the invention relates to processes for preparing said salts. The invention also relates to several aspects of using said salt or pharmaceutical composition to treat a disease.