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公开(公告)号：US11623773B2
公开(公告)日：2023-04-11
申请号：US17327527
申请日：2021-05-21
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Grant Anthony Bomgaars , Joseph Vincent Ranalletta , Yuanpang Samuel Ding , Ying-Cheng Lo , Mark Edward Pasmore , Michael Joseph Sadowski , Anastasios Hristakos , Thomas Edward Dudar , Bernd Krause
Abstract: A method of providing a plurality of filled product bags of sterile fluid includes positioning a bag assembly onto a filling machine. The bag assembly includes a tube, a filter assembly, bladders, and stems. A stem is attached to a bladder, forms a fluid passageway, fluidly connects to the tube, and provides fluid communication into the bladders. The method includes fluidly coupling an inlet of the filter assembly to a connection line in fluid communication with a fluid source, and filling the bag assembly with a fluid. Filling the bag assembly includes passing the fluid through the filter assembly, the fluid passageway, and into the bladder. The method includes sealing the fluid passageway at a location between the tube and the bladders. The method includes cutting the stem to form a partially filled product bag having the sealed passageway. The method includes performing an integrity test on the filter assembly.
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公开(公告)号：US11607479B2
公开(公告)日：2023-03-21
申请号：US17372984
申请日：2021-07-12
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Bijan Elahi , Ying-Cheng Lo , Vikram Prabhakar Mehendale
Abstract: A handheld personal communication apparatus for dialysis includes a reader to read a marking displayed on a dialysis fluid container to acquire data concerning at least one of a dialysis fluid type or a dialysis fluid volume from the marking; a processor using the at least one of the dialysis fluid type or the dialysis fluid volume to determine a dialysis dwell time for at least one cycle of a dialysis therapy, the dialysis dwell time being a time to achieve, over the at least one cycle, at least one of (a) a specified ultrafiltrate level, (b) a urea removal level, or (c) a creatinine removal level; and an output interface providing an indication to the patient of a completion of the dialysis dwell time.
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公开(公告)号：US11547797B2
公开(公告)日：2023-01-10
申请号：US16631051
申请日：2018-07-12
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Yuanpang Samuel Ding , Marc Steven Minkus , Ying-Cheng Lo , Mark Joseph Doty , Thomas Edward Dudar , Grant Anthony Bomgaars , Mark Edward Pasmore , Michael Joseph Sadowski , Anastasios Hristakos , Bernd Krause , Joseph Vincent Ranalletta
Abstract: A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.
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公开(公告)号：US20220211579A1
公开(公告)日：2022-07-07
申请号：US17701125
申请日：2022-03-22
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Yuanpang Samuel Ding , Ying-Cheng Lo , Jacob Daniel Rivett , Grant Anthony Bomgaars , Thomas Edward Dudar , Mark Edward Pasmore , Michael Joseph Sadowski , Anastasios Hristakos , Joseph Vincent Ranalletta , Bernd Krause
Abstract: A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.
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公开(公告)号：US20210353840A1
公开(公告)日：2021-11-18
申请号：US17388265
申请日：2021-07-29
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Rosa H. Yeh , Wei Xie , Hsinjin E. Yang , Michael T.K. Ling , Ying-Cheng Lo
Abstract: Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.
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Patent Agency Ranking
公开(公告)号：US20210338913A1
公开(公告)日：2021-11-04
申请号：US17372984
申请日：2021-07-12
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Bijan Elahi , Ying-Cheng Lo , Vikram Prabhakar Mehendale
Abstract: A handheld personal communication apparatus for dialysis includes a reader to read a marking displayed on a dialysis fluid container to acquire data concerning at least one of a dialysis fluid type or a dialysis fluid volume from the marking; a processor using the at least one of the dialysis fluid type or the dialysis fluid volume to determine a dialysis dwell time for at least one cycle of a dialysis therapy, the dialysis dwell time being a time to achieve, over the at least one cycle, at least one of (a) a specified ultrafiltrate level, (b) a urea removal level, or (c) a creatinine removal level; and an output interface providing an indication to the patient of a completion of the dialysis dwell time.
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公开(公告)号：US20200330672A1
公开(公告)日：2020-10-22
申请号：US16921478
申请日：2020-07-06
Applicant: Baxter International Inc. , Baxter Healthcare SA
Inventor： Robert W. Childers , Ying-Cheng Lo , Peter A. Hopping
Abstract: A system for performing a peritoneal dialysis therapy includes at least one dialysis fluid pump, and a logic implementer operable with the at least one dialysis fluid pump to perform a plurality of peritoneal dialysis cycles for a patient. The logic implementer transmits an amount of dialysis fluid provided during the plurality of peritoneal dialysis cycles. A server receives the amount of dialysis fluid provided during the plurality of peritoneal dialysis cycles and determines an amount of ultrafiltration (“UF”) removed from the patient based on the amount of dialysis fluid provided by the at least one dialysis fluid pump. The server also updates a UF trend using previous amounts of UF removed from the patient and the amount of UF removed from the patient during the most recent dialysis treatment and generates an alert if the UF trend changes by more than a preset percentage.
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公开(公告)号：US20190388611A1
公开(公告)日：2019-12-26
申请号：US16013228
申请日：2018-06-20
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Dustin Christopher Cawthon , Ieng Kin Lao , Thomas Edward Dudar , Yuanpang Samuel Ding , Ying-Cheng Lo , Houzhi Luo , Michael Patrick Morrissey , Jeffrey Scott Packard
Abstract: An infusion device for dispensing fluid at a predetermined flow rate includes an elastic bladder, a pressure regulator, and a flow restrictor. The elastic bladder includes a bladder volume portion and a bladder outlet, and the elastic bladder stores fluid in the bladder volume portion and dispenses fluid through the outlet at a bladder pressure. The pressure regulator is in fluid communication with the outlet of the elastic bladder. The pressure regulator includes a fluid inlet and a fluid outlet. The fluid inlet is coupled to the bladder outlet to receive fluid from the bladder. The flow restrictor is in fluid communication with the fluid outlet. The flow restrictor and the pressure regulator cooperate to discharge fluid from the flow restrictor at a predetermined flow rate.
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公开(公告)号：US20190262527A1
公开(公告)日：2019-08-29
申请号：US16412999
申请日：2019-05-15
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Rosa H. Yeh , Wei Xie , Hsinjin E. Yang , Michael T.K. Ling , Ying-Cheng Lo
Abstract: Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.
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公开(公告)号：US10342912B2
公开(公告)日：2019-07-09
申请号：US15816550
申请日：2017-11-17
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： Rosa H. Yeh , Wei Xie , Hsinjin E. Yang , Michael T. K. Ling , Ying-Cheng Lo
Abstract: Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.
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