公开(公告)号：US3852056A

公开(公告)日：1974-12-03

申请号：US7526470

申请日：1970-09-24

Applicant: BAYER AG

Inventor： SCHMIDT R ,  BUCHEL K ,  EUE L ,  DRABER W ,  REGEL E

IPC: C07D233/58 ,  A01N43/50 ,  A01N43/80 ,  C07D233/54 ,  C07D521/00 ,  A01N9/20

CPC classification number: C07D233/56 ,  C07D231/12 ,  C07D233/64 ,  C07D249/08

Abstract: Compositions containing heterocyclic-substituted Nbenzylimidazoles of the formula

WHEREIN R, R'' and R'''' are hydrogen, lower alkyl or lower alkenyl, X is hydrogen, halogen, lower alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, cyano, amino or dialkylamino, M IS 0, 1 OR 2, A is unsubstituted or substituted phenyl or pyridyl, alkyl or cycloalkyl, and B is a five-membered heteroaromatic ring of the general formula:

WHEREIN E is oxygen, sulfur

Y is hydrogen, lower alkyl, halogen or unsubstituted or substituted aryl; and N IS 0, 1 OR 2 POSSESS MARKED PLANT-GROWTH INFLUENCING, INCLUDING INHIBITING AND PROMOTING, PROPERTIES.

Abstract translation: 含有式WHEREIN R，R'和R“的杂环取代的N-苄基咪唑的组合物是氢，低级烷基或低级烯基，X是氢，卤素，低级烷基，烷氧基，烷硫基，三氟甲基，硝基，氰基，氨基或 二烷基氨基，M为0,1或2，A为未取代或取代的苯基或吡啶基，烷基或环烷基，B为下列通式的五元杂芳环：其中E为氧，硫为低级烷基， 卤素或未取代或取代的芳基; 和N IS 0，1或2标志性植物生长影响，包括抑制和促进，性质。

公开(公告)号：US3842175A

公开(公告)日：1974-10-15

申请号：US37280673

申请日：1973-06-22

Applicant: BAYER AG

Inventor： PLEMPEL M ,  REGEL E ,  BUCHEL K

IPC: C07D235/06 ,  C07D235/18 ,  A61K27/00

CPC classification number: C07D233/56 ,  C07D235/06 ,  C07D235/18

Abstract: WHEREIN R1 IS HYDROGEN OR ALKYL OF 1 TO 4 CARBON ATOMS; M IS 2 AND N IS 0 AND ONE X IS FLUORINE, CHLORINE, BROMINE OR IODINE AND OTHER X IS NO2, CN, ALKYL OF 1 TO 4 CARBON ATOMS, ALKOXY OF 1 TO 4 CARBON ATOMS, THIOMETHYL OR CF3; OR M IS 1 AND N IS 1 AND X IS FLUORINE, CHLORINE, BRMOINE, OR IODINE AND Y IS NO2, CN, ALKYL OF 1 TO 4 CARBON ATOMS, ALKOXY OF 1 TO 4 CARBON ATOMS, THIOMETHYL OR CF3; OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE NONTOXIC INERT DILUENT OR CARRIER.

1. A PHARMACEUTICAL COMPOSITION USEFUL FOR TREATING FUNGAL INFECTIONS PATHOGENIC TO HUMANS OR ANIMALS WHICH COMPRISES AN ANTIFUNGAL AMOUNT OF A COMPOUND OF THE FORMULA

(IMIDAZOL-1-YL)2 -C(-PHENYLENE-XM)-PHENYLENE-(Y)N

公开(公告)号：US3794653A

公开(公告)日：1974-02-26

申请号：US3794653D

申请日：1972-01-05

Applicant: BAYER AG

Inventor： DRABER W ,  REGEL E ,  BUECHEL K ,  PLEMPEL M

IPC: C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D521/00 ,  C07D31/46 ,  C07D31/50

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: SUBSTITUTED N-BENZYLIMIDAZOLES OF THE FORMULA:

1-(((X)M-PHENYL)-C(-A)(-B)-),2-R1,4-R3,5-R4-IMIDAZOLE

WHEREIN R1, R2 AND R3 ARE EACH HYDROGEN, STRAIGHT OR BRANCHED CHAIN LOWER ALKYL OR STRAIGHT OR BRANCHED CHAIN LOWER ALKENYL, X IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLMERCAPTO,LOWER ALKENYLMERCAPTO, TRIFLUOROMETHYL,HALOGEN,NITRO, CYANO, AMINO OR AMINO SUBSTITUTED BY 1 OR 2 ALIPHAIC MOIETIES. M IS 1 OR 2 A IS PHENYL; SUBSTITUTED PHENYL, PYRIDYL,LOWER ALKYL OR CYCLOALKYL, B US A 5-MEMBERED HETEROAROMATIC RING OF THE FORMULA

E
WHEREIN D IS CH OR N E IS OXYGEN, SULPHUR,N-LOWER ALKYL OR N-ARYL, Y IS HYDROGEN, 1 OR 2 LOWER ALKYLS,1 OR 2 HALOGENS, ARYL OR SUBSTITUTED ARYL, AND N IS 1 OR 2, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA:

(X)M,(A-C(-B)(-Z)-)BENZENE

WHEREIN A, B, X AND M ARE AS ABOVE DEFINED AND Z IS CHLORINE OR BROMINE,WITH AT LEAST THE THEORETICALLY NECESSARY AMOUNT OF IMIDAZOLE, OPTIONALLY IN THE PRESENCE OF AN ACID ACCEPTOR,IN A POLAR ORGANIC SOLVENT, AT A TEMPERATURE OF FROM 20* C. TO 150*C. THESE SUNSTITUTED N-BENZYLIMID AZOLES ARE USEFUL AS ANTIMYCOTICS AND ARE EFFECTIVE AGAINST BOTH YEASTS AND DERMATOPHYTES. THESE COMPOUNDS ARE EFFECTIVE AGAINST A WIDE RANGE OF FUNGI PATHOGENIC TO HUMANS AND ANIMALS.

公开(公告)号：US3755345A

公开(公告)日：1973-08-28

申请号：US3755345D

申请日：1970-09-24

Applicant: BAYER AG

Inventor： SCHMIDT R ,  EUE L ,  REGEL E ,  BUCHEL K

IPC: A01N43/653 ,  A01P21/00 ,  C07D249/08 ,  C07D521/00 ,  A01N9/22 ,  C07D55/06

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Bistriazolyl-bisphenyl-methanes, i.e., 3,3''-(fluoro, chloro, bromo, alkyl, aryl and substituted aryl) bistraizolebisphenyl(optionally halo, nitro, cyano, trifluoromethyl, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, phenyl, phenoxy, phenylthio, phenylsulfonyl and/or benzyl-substituted)bistriazolyl-bisphenyl methanes and their salts, possess plant growth influencing, i.e., both growth stimulating and inhibiting and ever herbicidal properties.

Abstract translation: 双三唑基 - 双苯基 - 甲烷，即3,3' - （氟，氯，溴，烷基，芳基和取代的芳基）双二硼基二苯基 - （任选卤素，硝基，氰基，三氟甲基，烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，苯基 苯氧基，苯硫基，苯基磺酰基和/或苄基取代的） - 双三唑基 - 双苯基甲烷及其盐具有影响植物生长，即生长刺激和抑制以及除草性质。

公开(公告)号：US3732232A

公开(公告)日：1973-05-08

申请号：US3732232D

申请日：1971-08-30

Applicant: BAYER AG

Inventor： REGEL E ,  EUE L ,  BUCHEL K

IPC: C07D471/04 ,  C07D57/04

CPC classification number: C07D471/04

Abstract: IMIDAZOISOQUINOLINEDIONES OF THE FORMULA

2-R3,3-R2,5,10-DI(O=)IMIDAZO(1,2-B)ISOQUINOLINE

ARE PREPARED SMOOTHYL AND WITHOUT SUBSTANTIAL BY-PRODUCT FORMATION BY REACTING A PHTHALIC ACID HALIDE OF THE FORMULA

1,2-DI(X-CO-),R1-BENZENE

WITH AN IMIDAZOLE OF THE FORMULA

5-R3,4-R2-IMIDAZOLE

R1 IS HYDROGEN, ALKYL, HALOGEN, NITRO OR ALKOXY, OR ARYL WHICH MAY BE SUBSTITUTED BY ALKYL, HALOGEN, HALOALKYL OR NITRO, R2 AND R3 INDIVIDUALLY ARE HYDROGEN, ALKYL, ARYL OR HALOGEN OR, TOGETHER WITH THE INTERMEDIATE TWO CARBON ATOMS OF THE IMIDAZOLE RING, REPRESENT A BENZENE RING, WHICH MAY BE SUBSTITUTED BY HALOGEN, NITRO OR TRIFLUOROMETHYL, AND X IS HALOGEN, PREFERABLY CHLORINE. THE PRODUCTS ARE HERBICIDES.

公开(公告)号：US3717657A

公开(公告)日：1973-02-20

申请号：US3717657D

申请日：1972-01-17

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: N-trityl-imidazoles and salts thereof of the formula:

WHEREIN R, R1 and R2 are hydrogen, lower alkyl or phenyl, or R1 and R2 together form an anellated benzene ring. X, X'' and X'''' are alkyl of one to 12 carbon atoms or an electronegative moiety, and N, N'' AND N'''' ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA:

WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND Hal is halogen. These compounds are useful as antimycotics.

Abstract translation: N-三苯甲基咪唑及其下式的盐：

公开(公告)号：US3711501A

公开(公告)日：1973-01-16

申请号：US3711501D

申请日：1972-01-17

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: N-TRITYL-IMIBAZOLES AND SALTS THEREOF OF THE FORMULA:

1-(((X)N-PHENYL-)((X'')N''-PHENYL-)((X")N"-PHENYL-)C-),2-R,

4-R1,5-R2-IMIDAZOLE

WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALT THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA:

2-R,4-R1,5-R2-IMIDAZOLE

WITH A TRITYL HALIDE OF THE FORMULA:

(((X)N-PHENYL-),((X'')N-PHENYL-)((X")N"-PHENYL-)C-HAL

WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANITMUCOTICS.

公开(公告)号：US3839573A

公开(公告)日：1974-10-01

申请号：US16127471

申请日：1971-07-09

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  A61K27/00

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: 1. AN ANTIFUNGAL COMPOSITION USEFUL FOR ADMINSTRATION TO HUMANS AND ANIMALS, WHICH COMPRISES AN AMOUNT OF A COMPOUND OF THE FORMULA: 1-((X"-PHENYL)-C(-C6H5)2-)IMIDAZOLE WHEREIN X" IS M-METHYL, OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF, SUFFICIENT TO BE THERAPEUTICALLY EFFECTIVE AGAINST FUNGI PATHOGENIC TO HUMANS AND ANIMALS, IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE NONTOXIC INERT DILUENT OR CARRIER.

公开(公告)号：US3833603A

公开(公告)日：1974-09-03

申请号：US29859972

申请日：1972-10-18

Applicant: BAYER AG

Inventor： REGEL E ,  HABERKORN A ,  BUCHEL K ,  DRABER W

IPC: C07D231/12 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D233/56 ,  C07D231/12 ,  C07D249/08

Abstract: 1 - (4-PHENOXYBENZYL)IMIDAZOLES BEARNG A PHENYL OR ALKYL GROUP IN THE A-POSITION AND A SECOND PHENYL GROUP IN THE A-POSITION ARE EFFECTIVE AGENTS AGAINST PROTOZOA. THE COMPOUNDS, OF WHICH 1- A-PHENYL-A-(4-BIPHENYL)4-PHENOXYBENZYL!IMIDAZOLE IS A TYPICAL EXAMPLE, CAN BE OBTAINED FROM THE REACTION OF IMIDAZOLE AND THE APPROPRIATELY SUBSTITUTED A,A-DISUBSTITUTED-4-PHENOXYBENZYL HALIDE.

公开(公告)号：US3824310A

公开(公告)日：1974-07-16

申请号：US18781471

申请日：1971-10-08

Applicant: BAYER AG

Inventor： REGEL E ,  BUCHEL K ,  PLEMPEL M

IPC: C07D235/06 ,  C07D235/18 ,  A61K27/00

CPC classification number: C07D233/56 ,  C07D235/06 ,  C07D235/18

Abstract: BIS-IMIDAZOLYL-BISPHENYLMETHANE ANDPHARMACEUTICALLY ACCEOPTABLE NON-TOXIC SALTS THEREOF ARE USEFUL AS ANTIMYCOTICS ESPECIALLY AGAINST DERMATOMYCOSIS CAUSED BY TRICHOPHYTON AND MICROSPORIUM SPECIES AND ALSO AGAINST YEAST INFECTIONS OF THE SKIN AND INTERNAL ORGANS.