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11.发明申请AMINO-HETEROARYL 7-HYDROXY-SPIROPIPERIDINE INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR 有权P2Y1受体的氨基 - 异羟肟酸7-羟基 - 螺吡啶吲哚宁拮抗剂公开(公告)号：US20150197521A1
公开(公告)日：2015-07-16
申请号：US14417985
申请日：2013-07-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Carol Hui Hu , Carl Thibeault
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的P2Y1受体的拮抗剂。
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12.发明申请公开(公告)号：US20140221357A1
公开(公告)日：2014-08-07
申请号：US14346745
申请日：2012-09-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D417/12 , C07D471/04 , C07D417/04 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/04 , C07D403/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US10577383B2
公开(公告)日：2020-03-03
申请号：US16099010
申请日：2017-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joanne M. Smallheer , Ellen K. Kick , Meriah Neissel Valente , Carol Hui Hu , Oz Scott Halpern , Sutjano Jusuf
IPC: C07D519/00 , A61P9/10
Abstract: The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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14.发明授权公开(公告)号：US09493412B2
公开(公告)日：2016-11-15
申请号：US14346751
申请日：2012-09-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Heather Finlay , Ji Jiang , John Lloyd , Carol Hui Hu , Zulan Pi , George O. Tora , James Neels , Jon J. Hangeland , Todd J. Friends
IPC: C07D207/38 , C07D409/12 , C07D471/04 , C07D401/12 , C07D413/12 , C07D417/12 , C07D403/12 , C07D401/04 , C07D405/12 , C07F7/08
CPC classification number: C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F7/0812
Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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公开(公告)号：US09428504B2
公开(公告)日：2016-08-30
申请号：US14418011
申请日：2013-07-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carl Thibeault , Charles G. Clark , Indawati DeLucca , Carol Hui Hu , Yoon Jeon , Patrick Y. S. Lam , Jennifer X. Qiao , Wu Yang , Yufeng Wang , Tammy C. Wang
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders.
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Patent Agency Ranking
公开(公告)号：US20150239879A1
公开(公告)日：2015-08-27
申请号：US14427105
申请日：2013-09-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Carol Hui Hu , Ji Jiang , James A. Johnson , Soong-Hoon Kim , John Lloyd , Brandon Parkhurst , Zulan Pi , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20150105376A1
公开(公告)日：2015-04-16
申请号：US14575203
申请日：2014-12-18
Applicant: Bristol-Myers Squibb Company
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D215/50 , C07D215/54 , C07D419/12 , C07D417/14 , C07D401/12 , C07D417/12
CPC classification number: C07D215/50 , C07D215/22 , C07D215/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D419/12
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US08946430B2
公开(公告)日：2015-02-03
申请号：US14347671
申请日：2012-09-24
Applicant: Bristol-Myers Squibb Company
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D215/38 , C07D215/50 , C07D403/12 , C07D401/14 , C07D215/22 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
CPC classification number: C07D215/50 , C07D215/22 , C07D215/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D419/12
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20140235608A1
公开(公告)日：2014-08-21
申请号：US14347683
申请日：2012-09-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： John Lloyd , Jeniffer X. Qiao , Heather Finlay , James Neels , Zulan Pi , Carol Hui Hu , Tammy C. Wang
IPC: C07D417/12 , C07D401/12 , C07D413/12 , C07D213/81
CPC classification number: C07D213/81 , C07D213/79 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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20.发明申请公开(公告)号：US20140213588A1
公开(公告)日：2014-07-31
申请号：US14346747
申请日：2012-09-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D417/06 , C07D417/04 , C07D409/04 , C07D413/06 , C07D405/06 , C07D233/61 , C07D401/06 , C07D207/277 , C07D405/04
CPC classification number: C07D207/277 , C07D207/28 , C07D207/38 , C07D233/61 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provides a novel method of treating diseases or conditions related to the activity of endothelial lipase by use of compounds according to Formula (II): as defined in the specification and compositions comprising any of the compounds.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。 本公开还提供了一种通过使用根据式（II）的化合物来治疗与内皮脂肪酶活性相关的疾病或病症的新方法：如说明书中所定义和包含任何化合物的组合物。
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