公开(公告)号：US10245302B2

公开(公告)日：2019-04-02

申请号：US15282277

申请日：2016-09-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Sharon Cload ,  Linda Engle ,  Dasa Lipovsek ,  Malavi Madireddi ,  Ginger Chao Rakestraw ,  Joanna Swain ,  Wenjun Zhao ,  Hui Wei ,  Aaron P. Yamniuk ,  Vidhyashankar Ramamurthy ,  Alexander T. Kozhich ,  Martin J. Corbett ,  Stanley Richard Krystek, Jr.

IPC: C12P21/02 ,  C07K14/78 ,  A61K38/39 ,  C07K16/46 ,  A61K45/06 ,  G01N33/74 ,  C07K14/435 ,  C07K14/765 ,  C07K14/79 ,  C07K16/18 ,  A61K38/17 ,  A61K47/64 ,  A61K47/60 ,  A61K47/48 ,  A61K38/00

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

公开(公告)号：US10183987B2

公开(公告)日：2019-01-22

申请号：US15684595

申请日：2017-08-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stuart Emanuel ,  Linda Engle ,  Ray Camphausen ,  Martin C. Wright ,  Ginger Chao Rakestraw ,  Marco Gottardis ,  Joan Carboni

IPC: A61K38/16 ,  A61K38/39 ,  C07K14/475 ,  C07K14/78 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.

公开(公告)号：US09771411B2

公开(公告)日：2017-09-26

申请号：US14664290

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stuart Emanuel ,  Linda Engle ,  Ray Camphausen ,  Martin C. Wright ,  Ginger Chao Rakestraw ,  Marco Gottardis ,  Joan Carboni

IPC: A61K38/16 ,  A61K38/39 ,  C07K14/435 ,  C07K14/475 ,  C07K14/78 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/705 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/39 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/475 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/30

Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.

公开(公告)号：US20150274806A1

公开(公告)日：2015-10-01

申请号：US14553379

申请日：2014-11-25

Applicant: Bristol-Myers Squibb Company

Inventor： Ruchira DASGUPTA ,  Alex Bush ,  Lumelle Schneeweis ,  Linda Engle

IPC: C07K14/78 ,  A61K38/39 ,  A61K47/48

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K38/39 ,  A61K47/60 ,  C07K2318/20 ,  C07K2319/70 ,  C12N15/1044

Abstract: The present invention relates to fibronectin based scaffold domain protein that bind interleukin 23 (IL-23), specifically the p19 subunit of IL-23. The invention also relates to the use of the innovative proteins in therapeutic applications to treat autoimmune diseases. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

Abstract translation: 本发明涉及结合白介素23（IL-23），特别是IL-23的p19亚基的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新蛋白在治疗应用中用于治疗自身免疫性疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。