公开(公告)号：US20160158200A1

公开(公告)日：2016-06-09

申请号：US14903024

申请日：2013-07-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Piyasena Hewawasam ,  Omar D. Lopez ,  Yong Tu ,  Alan Xiangdong Wang ,  Ningning Xu ,  John F. Kadow ,  Nicholas A. Meanwell ,  Samayamunthula Venkata Satya Arun Kumar Gupta ,  Indasi J. Gopi Kumar ,  Suresh Kumar Punugupati ,  Makonen Belema

IPC: A61K31/4178 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/695 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/437 ,  A61K31/5365 ,  A61K31/519 ,  A61K45/06 ,  A61K31/4725

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：US20150297568A1

公开(公告)日：2015-10-22

申请号：US14753564

申请日：2015-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Piyasena Hewawasam ,  Omar D. Lopez ,  Yong Tu ,  Alan Xiangdong Wang ,  Ningning Xu ,  John F. Kadow ,  Nicholas A. Meanwell ,  Samayamunthula Venkata Satya Arun Kumar Gupta ,  Indasi J. Gopi Kumar ,  Suresh Kumar Ponugupati ,  Makonen Belema

IPC: A61K31/4178 ,  A61K38/21 ,  A61K31/7056 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/695 ,  A61K31/4725 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/402 ,  A61K31/5365

CPC classification number: A61K31/4178 ,  A61K31/402 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/208 ,  A61K38/21 ,  A61K45/06 ,  C07D233/64 ,  C07D403/14 ,  C07D405/14 ,  C07D493/08 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：US20150023913A1

公开(公告)日：2015-01-22

申请号：US13933495

申请日：2013-07-02

Applicant: Bristol-Myers Squibb Company

Inventor： Piyasena Hewawasam ,  Omar D. Lopez ,  Yong Tu ,  Alan Xiangdong Wang ,  Ningning Xu ,  John F. Kadow ,  Nicholas A. Meanwell ,  Samayamuthula Venkata Satya Arun Kumar Gupta ,  Indasi J. Gopi Kumar ,  Suresh Kumar Ponugupati ,  Makonen Belema

IPC: A61K38/21 ,  A61K31/4178 ,  A61K31/7056 ,  A61K31/4245 ,  C07D233/64 ,  C07D403/14 ,  C07D493/08 ,  A61K31/4725 ,  C07D405/14 ,  A61K45/06

CPC classification number: A61K31/4178 ,  A61K31/402 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/208 ,  A61K38/21 ,  A61K45/06 ,  C07D233/64 ,  C07D403/14 ,  C07D405/14 ,  C07D493/08 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.