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公开(公告)号：US20130183269A1
公开(公告)日：2013-07-18
申请号：US13735224
申请日：2013-01-07
Applicant: Bristol-Myers Squibb Company
Inventor： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC: A61K31/4178 , A61K31/407 , A61K31/422 , A61K31/444 , A61K31/423 , A61K31/497 , A61K31/4545 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/437 , A61K31/519 , A61K31/428 , A61K31/501 , A61K31/55 , A61K31/496 , A61K31/4184 , A61K45/06 , C07D403/14 , C07D491/113 , A61K31/7056 , A61K38/21 , A61K38/05
CPC classification number: A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US20180221342A1
公开(公告)日：2018-08-09
申请号：US15749557
申请日：2016-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David B. Frennesson , Piyasena Hewawasam , Omar D. Lopez , Van N. Nguyen , Mark G. Saulnier , Yong Tu , Alan Xiangdong Wang , Gan Wang , Ningning Xu , Roshan Yadavrao Nimje , Hasibur Rahaman , Samayamunthula Venkata Satya Arun Kumar Gupta , Nicholas A. Meanwell , Makonen Belema
IPC: A61K31/4178 , A61P31/14
CPC classification number: A61K31/4178 , A61K31/417 , A61K31/4184 , A61K31/4439 , A61K31/497 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00 , A61P31/14
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US10150747B2
公开(公告)日：2018-12-11
申请号：US15551017
申请日：2016-02-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Samayamunthula Venkata Satya Arun Kumar Gupta
IPC: C07D405/12 , C07D405/14 , C07D307/84 , C07D413/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07B59/00
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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Patent Agency Ranking
公开(公告)号：US09770439B2
公开(公告)日：2017-09-26
申请号：US14753564
申请日：2015-06-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC: A61K31/415 , A61K31/535 , C07D471/04 , A61K31/40 , A61K31/44 , A61K31/4178 , A61K38/21 , A61K31/4245 , A61K31/4725 , A61K31/7056 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K31/437 , A61K31/439 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/454 , A61K31/4545 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K38/20
CPC classification number: A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US09326973B2
公开(公告)日：2016-05-03
申请号：US13735224
申请日：2013-01-07
Applicant: Bristol-Myers Squibb Company
Inventor： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC: A61K31/415 , A61K31/675 , A61K38/00 , A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K45/06 , C07D403/14 , C07D491/113
CPC classification number: A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US11161837B2
公开(公告)日：2021-11-02
申请号：US16083972
申请日：2017-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Kumaravel Selvakumar , Samayamunthula Venkata Satya Arun Kumar Gupta
IPC: C07D405/12 , C07D307/84 , C07D413/12 , A61K31/343 , A61K31/4245 , A61K31/506 , A61P31/00 , A61P31/14
Abstract: The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20160158200A1
公开(公告)日：2016-06-09
申请号：US14903024
申请日：2013-07-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Punugupati , Makonen Belema
IPC: A61K31/4178 , A61K31/444 , A61K31/4439 , A61K31/497 , A61K31/695 , A61K31/4545 , A61K31/5377 , A61K31/437 , A61K31/5365 , A61K31/519 , A61K45/06 , A61K31/4725
CPC classification number: A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20150297568A1
公开(公告)日：2015-10-22
申请号：US14753564
申请日：2015-06-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC: A61K31/4178 , A61K38/21 , A61K31/7056 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K31/519 , A61K31/695 , A61K31/4725 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/402 , A61K31/5365
CPC classification number: A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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