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公开(公告)号：US09326973B2
公开(公告)日：2016-05-03
申请号：US13735224
申请日：2013-01-07
发明人： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC分类号： A61K31/415 , A61K31/675 , A61K38/00 , A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K45/06 , C07D403/14 , C07D491/113
CPC分类号： A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20160158200A1
公开(公告)日：2016-06-09
申请号：US14903024
申请日：2013-07-09
发明人： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Punugupati , Makonen Belema
IPC分类号： A61K31/4178 , A61K31/444 , A61K31/4439 , A61K31/497 , A61K31/695 , A61K31/4545 , A61K31/5377 , A61K31/437 , A61K31/5365 , A61K31/519 , A61K45/06 , A61K31/4725
CPC分类号： A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20150297568A1
公开(公告)日：2015-10-22
申请号：US14753564
申请日：2015-06-29
发明人： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC分类号： A61K31/4178 , A61K38/21 , A61K31/7056 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K31/519 , A61K31/695 , A61K31/4725 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/402 , A61K31/5365
CPC分类号： A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20150023913A1
公开(公告)日：2015-01-22
申请号：US13933495
申请日：2013-07-02
发明人： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamuthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC分类号： A61K38/21 , A61K31/4178 , A61K31/7056 , A61K31/4245 , C07D233/64 , C07D403/14 , C07D493/08 , A61K31/4725 , C07D405/14 , A61K45/06
CPC分类号： A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US09717712B2
公开(公告)日：2017-08-01
申请号：US14904817
申请日：2014-07-15
发明人： Alan Xiangdong Wang , Omar D. Lopez , Yong Tu , Makonen Belema
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4178 , A61K38/21 , A61K31/7056
CPC分类号： A61K31/4184 , A61K31/4178 , A61K31/7056 , A61K38/21 , A61K38/212 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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6.发明申请Combinations Comprising Tricyclohexadecahexaene Derivatives for Use in the Treatment of Hepatitis C Virus 审中-公开包含用于治疗丙型肝炎病毒的三环十六碳六烯衍生物的组合公开(公告)号：US20160166547A1
公开(公告)日：2016-06-16
申请号：US14904817
申请日：2014-07-15
发明人： Alan Xiangdong Wang , Omar D. Lopez , Yong Tu , Makonen Belema
IPC分类号： A61K31/4184 , A61K38/21 , A61K31/7056 , A61K31/4178
CPC分类号： A61K31/4184 , A61K31/4178 , A61K31/7056 , A61K38/21 , A61K38/212 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20130183269A1
公开(公告)日：2013-07-18
申请号：US13735224
申请日：2013-01-07
发明人： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC分类号： A61K31/4178 , A61K31/407 , A61K31/422 , A61K31/444 , A61K31/423 , A61K31/497 , A61K31/4545 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/437 , A61K31/519 , A61K31/428 , A61K31/501 , A61K31/55 , A61K31/496 , A61K31/4184 , A61K45/06 , C07D403/14 , C07D491/113 , A61K31/7056 , A61K38/21 , A61K38/05
CPC分类号： A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US09770439B2
公开(公告)日：2017-09-26
申请号：US14753564
申请日：2015-06-29
发明人： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC分类号： A61K31/415 , A61K31/535 , C07D471/04 , A61K31/40 , A61K31/44 , A61K31/4178 , A61K38/21 , A61K31/4245 , A61K31/4725 , A61K31/7056 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K31/437 , A61K31/439 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/454 , A61K31/4545 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K38/20
CPC分类号： A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US20180221342A1
公开(公告)日：2018-08-09
申请号：US15749557
申请日：2016-07-27
发明人： David B. Frennesson , Piyasena Hewawasam , Omar D. Lopez , Van N. Nguyen , Mark G. Saulnier , Yong Tu , Alan Xiangdong Wang , Gan Wang , Ningning Xu , Roshan Yadavrao Nimje , Hasibur Rahaman , Samayamunthula Venkata Satya Arun Kumar Gupta , Nicholas A. Meanwell , Makonen Belema
IPC分类号： A61K31/4178 , A61P31/14
CPC分类号： A61K31/4178 , A61K31/417 , A61K31/4184 , A61K31/4439 , A61K31/497 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00 , A61P31/14
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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