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公开(公告)号：US20190002441A1
公开(公告)日：2019-01-03
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D403/02 , C07D417/14 , A61K31/505 , C07D239/557 , C07D401/14 , C07D401/06 , C07D471/04 , C07D239/54 , C07D239/545 , C07D403/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10106528B2
公开(公告)日：2018-10-23
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04 , C07D401/06 , C07D403/14 , C07D239/557
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US09701672B2
公开(公告)日：2017-07-11
申请号：US15123791
申请日：2015-03-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Guohua Zhao
IPC: C07D409/14 , C07D401/14 , C07D401/04 , C07D409/04 , C07D417/14 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06
CPC classification number: C07D409/14 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D409/04 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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14.发明申请DIHYDROPYRIDINONE MGAT2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS 有权用于治疗代谢障碍的二氢吡啶酮MGAT2抑制剂公开(公告)号：US20170015653A1
公开(公告)日：2017-01-19
申请号：US15123791
申请日：2015-03-05
Applicant: Bristol-Myers Squibb Company
Inventor： Wei Meng , Guohua Zhao
IPC: C07D409/14 , A61K31/4439 , C07D417/14 , C07D401/04 , A61K31/444 , A61K31/506 , A61K31/4436 , C07D409/04 , A61K45/06 , C07D401/14
CPC classification number: C07D409/14 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D409/04 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的单酰基甘油酰基转移酶2型（MGAT2）抑制剂。
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公开(公告)号：US10889565B2
公开(公告)日：2021-01-12
申请号：US16309168
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ji Jiang , Heather Finlay , Soong-Hoon Kim , Wei Meng , George O. Tora
IPC: C07D401/12 , C07D221/00 , C07D401/14 , C07D413/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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Patent Agency Ranking
公开(公告)号：US20200281905A1
公开(公告)日：2020-09-10
申请号：US16879810
申请日：2020-05-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: A61K31/438 , A61K31/675 , C07D211/90 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K45/06 , C07F9/59 , C07F9/40 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07D405/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：US10695328B2
公开(公告)日：2020-06-30
申请号：US16445913
申请日：2019-06-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: A61K31/438 , A61K31/675 , C07D211/90 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K45/06 , C07F9/59 , C07F9/40 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07D405/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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18.发明授权公开(公告)号：US10597370B2
公开(公告)日：2020-03-24
申请号：US16302158
申请日：2017-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Wei Meng
IPC: A61K31/428 , C07D277/64 , C07D417/10 , C07D513/04 , C07D417/04 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
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公开(公告)号：US10369140B2
公开(公告)日：2019-08-06
申请号：US15867825
申请日：2018-01-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: C07F9/40 , C07F9/59 , A61K45/06 , C07F9/535 , A61K31/438 , A61K31/675 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/4418 , A61K31/4439 , A61K31/5377
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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20.发明申请公开(公告)号：US20190144403A1
公开(公告)日：2019-05-16
申请号：US16302158
申请日：2017-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Wei Meng
IPC: C07D277/64 , C07D417/10 , C07D417/14 , C07D513/04
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/14 , C07D513/04
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
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