专利检索 ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Robert Paul Brigance" 第 1 页

1.

发明授权
Heteroarylhydroxypyrimidinones as agonists of the APJ receptor 审中-公开

公开(公告)号：US10669261B2

公开(公告)日：2020-06-02

申请号：US16061365

申请日：2016-12-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay

IPC分类号： A61K31/506 , A61K31/513 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/00

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.

2.

发明授权
Aryl dihydropyridinones and piperidinone MGAT2 inhibitors 有权

公开(公告)号：US09901572B2

公开(公告)日：2018-02-27

申请号：US15488642

申请日：2017-04-17

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao

IPC分类号： C07D211/90 , C07D401/04 , A61K31/4439 , A61K31/438 , A61K31/675 , A61K31/4418 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07F9/59 , C07D401/14 , A61K45/06 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07F9/40 , C07D405/14

CPC分类号： A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

3.

发明申请
6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS 审中-公开

公开(公告)号：US20190002441A1

公开(公告)日：2019-01-03

申请号：US16122975

申请日：2018-09-06

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang

IPC分类号： C07D403/06 , C07D403/02 , C07D417/14 , A61K31/505 , C07D239/557 , C07D401/14 , C07D401/06 , C07D471/04 , C07D239/54 , C07D239/545 , C07D403/14

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

4.

发明授权
6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists 有权

公开(公告)号：US10106528B2

公开(公告)日：2018-10-23

申请号：US15468230

申请日：2017-03-24

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang

IPC分类号： C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04 , C07D401/06 , C07D403/14 , C07D239/557

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

5.

发明申请
ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS 有权

公开(公告)号：US20210161869A1

公开(公告)日：2021-06-03

申请号：US17177327

申请日：2021-02-17

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao

IPC分类号： A61K31/438 , C07D405/14 , C07D221/20 , C07D401/12 , A61K31/4418 , C07D211/90 , C07D417/04 , C07D407/14 , A61K31/675 , C07D401/04 , C07D417/14 , C07D413/12 , A61K45/06 , C07D211/86 , C07F9/40 , C07D413/14 , C07D413/04 , A61K31/4439 , C07F9/535 , C07D401/14 , A61K31/5377 , C07D401/10 , C07F9/59

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

6.

发明授权
Aryl dihydropyridinones and piperidinone MGAT2 inhibitors 有权

公开(公告)号：US10966967B2

公开(公告)日：2021-04-06

申请号：US16879810

申请日：2020-05-21

申请人： Bristol-Myers Squibb Company

发明人： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao

IPC分类号： A61K31/438 , A61K31/675 , C07D211/90 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K45/06 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07F9/59 , C07F9/40 , C07D211/86 , C07F9/535 , C07D405/14

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

7.

发明申请
6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS 审中-公开

公开(公告)号：US20170275272A1

公开(公告)日：2017-09-28

申请号：US15468230

申请日：2017-03-24

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang

IPC分类号： C07D403/06 , C07D471/04 , C07D417/14 , C07D401/14

CPC分类号： C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D239/557 , C07D401/06 , C07D401/14 , C07D403/02 , C07D403/14 , C07D417/14 , C07D471/04

摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

8.

发明申请
ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS 有权
标题翻译： ARYL DIHYDROPRIDINONE和PIPERIDINONE MGAT2 INHIBITORS

公开(公告)号：US20130143843A1

公开(公告)日：2013-06-06

申请号：US13688584

申请日：2012-11-29

申请人： Bristol-Myers Squibb Company

发明人： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Dong Cheng , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale

IPC分类号： A61K31/675 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , A61K45/06 , A61K31/438 , C07D413/14 , A61K31/5377 , C07F9/59 , C07D401/14 , C07D211/90 , C07D221/20

CPC分类号： A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

摘要翻译： 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是可用作药物的单酰基甘油酰基转移酶2型（MGAT2）抑制剂。