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公开(公告)号：US20180362508A1
公开(公告)日：2018-12-20
申请号：US16061365
申请日：2016-12-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC: C07D403/04 , C07D413/14 , C07D413/04 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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公开(公告)号：US20170275272A1
公开(公告)日：2017-09-28
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D471/04 , C07D417/14 , C07D401/14
CPC classification number: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D239/557 , C07D401/06 , C07D401/14 , C07D403/02 , C07D403/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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Patent Agency Ranking
公开(公告)号：US20190002441A1
公开(公告)日：2019-01-03
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D403/02 , C07D417/14 , A61K31/505 , C07D239/557 , C07D401/14 , C07D401/06 , C07D471/04 , C07D239/54 , C07D239/545 , C07D403/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10106528B2
公开(公告)日：2018-10-23
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04 , C07D401/06 , C07D403/14 , C07D239/557
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10669261B2
公开(公告)日：2020-06-02
申请号：US16061365
申请日：2016-12-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC: A61K31/506 , A61K31/513 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/00
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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公开(公告)号：US20230322803A1
公开(公告)日：2023-10-12
申请号：US17913206
申请日：2021-03-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Andrew P. Degnan , Godwin Kwame Kumi , Andrew J. Tebben , Audris Huang , Peter Kinam Park , Donna M. Bilder , Emily Charlotte Cherney , Ashok Vinayak Purandare
IPC: C07D498/04 , C07D471/04 , C07D401/14
CPC classification number: C07D498/04 , C07D401/14 , C07D471/04
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein Ring A is a carbon-linked ring; and Ring A, R1, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US10590113B2
公开(公告)日：2020-03-17
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: A61K31/505 , C07D403/06 , C07D401/06 , C07D403/14 , C07D239/557 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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