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    2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
    12.
    发明授权
    2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors 失效
    可用作一氧化氮合酶抑制剂的2-氨基-3,4-庚烯化合物

    公开(公告)号：US06956131B2

    公开(公告)日：2005-10-18

    申请号：US09834815

    申请日：2001-04-13

    申请人： Barnett S. Pitzele ,  James A. Sikorski ,  Ronald Keith Webber

    发明人： Barnett S. Pitzele ,  James A. Sikorski ,  Ronald Keith Webber

    IPC分类号： C07C257/12 ,  C07C251/00

    CPC分类号： C07C257/12

    摘要： The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R2 is selected from the group consisting of H and methyl; and R2 is selected from the group consisting of H and methyl. The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中：R 2选自H和甲基; 和R 2选自H和甲基。 该化合物具有有用的一氧化氮合成酶抑制活性，并且预期可用于治疗或预防一氧化氮的合成或过度合成形成贡献部分的疾病或病症。

    2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    13.
    发明授权
    2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效
    可用作一氧化氮合酶抑制剂的2-氨基-4,5-庚烯酸衍生物

    公开(公告)号：US06787668B2

    公开(公告)日：2004-09-07

    申请号：US09835196

    申请日：2001-04-13

    申请人： Barnett S. Pitzele ,  James A. Sikorski ,  Ronald Keith Webber

    发明人： Barnett S. Pitzele ,  James A. Sikorski ,  Ronald Keith Webber

    IPC分类号： C07C25700

    CPC分类号： C07C257/14

    摘要： The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H and methyl; and R2 is selected from the group consisting of H and methyl. The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中：R 1选自H和甲基; 并且R 2选自H和甲基。化合物具有有效的一氧化氮合成酶抑制活性，并且预期可用于治疗或预防一氧化氮的合成或过度合成形成疾病或病症 贡献部分