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公开(公告)号：US06495544B2
公开(公告)日：2002-12-17
申请号：US09920612
申请日：2001-08-01
申请人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
IPC分类号： A61K3155
CPC分类号： C07D223/12 , C07D223/10
摘要： Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
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公开(公告)号：US06403830B2
公开(公告)日：2002-06-11
申请号：US09816577
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
IPC分类号： C07C32358
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US06914158B2
公开(公告)日：2005-07-05
申请号：US10815375
申请日：2004-04-01
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61P1/00 , A61K31/198 , A61K31/4166 , A61K31/4245 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P39/02 , A61P43/00 , C07C317/48 , C07C317/50 , C07C323/58 , C07C323/59 , C07D233/76 , C07D271/06 , C07D271/07 , C07D277/56 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
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4.发明授权Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权制备脒基化合物可用作一氧化氮合酶抑制剂的方法公开(公告)号：US07102013B2
公开(公告)日：2006-09-05
申请号：US10321969
申请日：2002-12-17
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： C07D233/40 , C07C271/00 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.
摘要翻译： 制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。
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公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
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公开(公告)号：US06586474B2
公开(公告)日：2003-07-01
申请号：US09816575
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
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7.发明授权Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤化2-氨基-3,4-庚烯酸衍生物公开(公告)号：US06586471B1
公开(公告)日：2003-07-01
申请号：US09835193
申请日：2001-04-13
申请人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
IPC分类号： A61K3122
CPC分类号： C07D209/48 , C07C257/14 , C07D263/04 , C07D263/06 , C07D413/06
摘要： The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-3,4-庚烯酸衍生物。
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公开(公告)号：US06638758B2
公开(公告)日：2003-10-28
申请号：US09876199
申请日：2001-06-06
申请人： Donald W. Hansen, Jr. , Mahima Trivedi , Rolando E. Gapud , John S. Ng , Alok K. Awasthi , Ping T. Wang
发明人： Donald W. Hansen, Jr. , Mahima Trivedi , Rolando E. Gapud , John S. Ng , Alok K. Awasthi , Ping T. Wang
IPC分类号： C07C104
CPC分类号： C12P17/10 , C12P17/12 , C12P41/005
摘要： A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.
摘要翻译： 分离对映体内酰胺酯的方法。 将内酰胺酯与生物催化剂如酶或微生物在溶液中接触，其中只有一个对映体被选择性水解，得到相应酸的旋光异构体。 然后将水解产物与未反应的内酰胺酯分离。 然后将酶再循环以在下一酶分解中重新使用。 不需要的异构体也是外消旋化的并且在下一个酶解决方案中重复使用。
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公开(公告)号：US06277626B1
公开(公告)日：2001-08-21
申请号：US09250197
申请日：1999-02-16
申请人： Donald W. Hansen, Jr. , Mahima Trivedi , Rolando E. Gapud , John S. Ng , Alok K. Awasthi , Ping T. Wang
发明人： Donald W. Hansen, Jr. , Mahima Trivedi , Rolando E. Gapud , John S. Ng , Alok K. Awasthi , Ping T. Wang
IPC分类号： C07C104
CPC分类号： C12P17/10 , C12P17/12 , C12P41/005
摘要： A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.
摘要翻译： 分离对映体内酰胺酯的方法。 将内酰胺酯与生物催化剂如酶或微生物在溶液中接触，其中只有一个对映体被选择性水解，得到相应酸的旋光异构体。 然后将水解产物与未反应的内酰胺酯分离。 然后将酶再循环以在下一酶分解中重新使用。 不需要的异构体也是外消旋化的并且在下一个酶解决方案中重复使用。
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公开(公告)号：US6043261A
公开(公告)日：2000-03-28
申请号：US199899
申请日：1998-11-25
申请人： Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
发明人： Donald W. Hansen, Jr. , E. Ann Hallinan , Timothy J. Hagen , Steven W. Kramer , Suzanne Metz , Karen B. Peterson , Dale P. Spangler , Mihaly V. Toth , Kam F. Fok , Arija A. Bergmanis , R. Keith Webber , Mahima Trivedi , Foe S. Tjoeng , Barnett S. Pitzele
IPC分类号： C07D319/06 , A61K31/045 , A61K31/12 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/42 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/30 , A61P29/00 , A61P43/00 , C07C251/44 , C07D207/22 , C07D211/72 , C07D211/76 , C07D223/10 , C07D223/12 , C07D225/02 , C07D309/06 , C07D333/16 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D521/00 , A01W57/00
CPC分类号： C07D249/08 , C07D207/22 , C07D211/72 , C07D223/12 , C07D225/02 , C07D231/12 , C07D233/56 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明公开了可用作一氧化氮合酶抑制剂的有用的吡咯烷亚胺衍生物。
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